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Author Details

Lea Harrington
Institute for Research in Immunology and Cancer, Universite de Montreal
1988
78
35
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
34514660The association between female reproductive performance and leukocyte telomere length in wild Soay sheep.Mol Ecol2022
36441670Aberrant expression and localization of the RAP1 shelterin protein contribute to age-related phenotypes.PLoS Genet2022
35920280Tieing together loose ends: telomere instability in cancer and aging.Mol Oncol2022
35023164Hypophosphorylated pRb knock-in mice exhibit hallmarks of aging and vitamin C-preventable diabetes.EMBO J2022
34679099CAMAP: Artificial neural networks unveil the role of codon arrangement in modulating MHC-I peptides presentation.PLoS Comput Biol2021
33876756Heritable variation in telomere length predicts mortality in Soay sheep.Proc Natl Acad Sci U S A2021
33930985Catechin from <i>Burkea africana</i> Hook. Exhibits <i>in vitro</i> inhibition of human telomerase activity.Nat Prod Res2021
33660365A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition.Aging Cell2021
32297856Telomere dysfunction cooperates with epigenetic alterations to impair murine embryonic stem cell fate commitment.Elife2020
32010151Qualitative Changes in Cortical Thymic Epithelial Cells Drive Postpartum Thymic Regeneration.Front Immunol2020
32935380Re-equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunction.EMBO J2020
32755594Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells.Mol Cell2020
32241622Editorial overview: The instability of the cancer genome: it starts at the end.Curr Opin Genet Dev2020
29335368<i>In medio stat virtus</i>: unanticipated consequences of telomere dysequilibrium.Philos Trans R Soc Lond B Biol Sci2018
29335374Understanding diversity in telomere dynamics.Philos Trans R Soc Lond B Biol Sci2018
28725051Mammographic density, blood telomere length and lipid peroxidation.Sci Rep2017
26923168Inactivation of Pif1 helicase causes a mitochondrial myopathy in mice.Mitochondrion2016
26521726Lifelong leukocyte telomere dynamics and survival in a free-living mammal.Aging Cell2016
27300435Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells.Cancer Cell2016
27115835Rapid Discovery and Structure-Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase.J Med Chem2016
25572391Defective repair of uracil causes telomere defects in mouse hematopoietic cells.J Biol Chem2015
26918148The lighthouse at the end of the chromosome.F1000Res2015
25484304Enforced telomere elongation increases the sensitivity of human tumour cells to ionizing radiation.DNA Repair (Amst)2015
25329304Break-induced replication requires DNA damage-induced phosphorylation of Pif1 and leads to telomere lengthening.PLoS Genet2014
25493413Targeted protein degradation as a tumor suppressor.Cell Cycle2014
23561444Short telomeres in ESCs lead to unstable differentiation.Cell Stem Cell2013
23772418Telomeres, a busy platform for cell signaling.Front Oncol2013
23521791A yeast chemical genetic screen identifies inhibitors of human telomerase.Chem Biol2013
23518559Cancer: Trouble upstream.Nature2013
22100521Haploinsufficiency and telomere length homeostasis.Mutat Res2012
22832159Long telomeres bypass the requirement for telomere maintenance in human tumorigenesis.Cell Rep2012
22187156Native gel electrophoresis of human telomerase distinguishes active complexes with or without dyskerin.Nucleic Acids Res2012
21945094PIF1 disruption or NBS1 hypomorphism does not affect chromosome healing or fusion resulting from double-strand breaks near telomeres in murine embryonic stem cells.DNA Repair (Amst)2011
22011238The TPR-containing domain within Est1 homologs exhibits species-specific roles in telomerase interaction and telomere length homeostasis.BMC Mol Biol2011
20034955The N-terminus of hTERT contains a DNA-binding domain and is required for telomerase activity and cellular immortalization.Nucleic Acids Res2010
20650001Troglitazone suppresses telomerase activity independently of PPARgamma in estrogen-receptor negative breast cancer cells.BMC Cancer2010
19071232No attenuation of the ATM-dependent DNA damage response in murine telomerase-deficient cells.DNA Repair (Amst)2009
19841238Telomerase reverse transcriptase-dependent telomere equilibration mitigates tissue dysfunction in mTert heterozygotes.Dis Model Mech2009
19380905Telomere maintenance and survival in saccharomyces cerevisiae in the absence of telomerase and RAD52.Genetics2009
17130244Murine Pif1 interacts with telomerase and is dispensable for telomere function in vivo.Mol Cell Biol2007
16564010A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator.Cell2006
16761726Quantitative analysis of telomerase activity and telomere length in domestic animal clones.Methods Mol Biol2006
16504006Strict control of telomerase activation using Cre-mediated inversion.BMC Biotechnol2006
16612004The retinoblastoma protein regulates pericentric heterochromatin.Mol Cell Biol2006
15701761The p80 homology region of TEP1 is sufficient for its association with the telomerase and vault RNAs, and the vault particle.Nucleic Acids Res2005
16132814Making the most of a little: dosage effects in eukaryotic telomere length maintenance.Chromosome Res2005
16172394Dissociation of telomerase activity and telomere length maintenance in primitive human hematopoietic cells.Proc Natl Acad Sci U S A2005
16284252The effect of TERC haploinsufficiency on the inheritance of telomere length.Proc Natl Acad Sci U S A2005
15976286Problems with co-funding in Canada.Science2005
16094415Direct evidence for cooperating genetic events in the leukemic transformation of normal human hematopoietic cells.Leukemia2005
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Collaborators

Mike Tyers
Institute for Research in Immunology and Cancer (IRIC), Universite de Montreal
Co-authored papers 5
Andrew Wakeham
Princess Margaret Cancer Centre, Ontario Cancer Institute, University Health Network
Co-authored papers 4
John E Dick
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 3
Laura Maringele
Newcastle University Biosciences Institute, Newcastle University
Co-authored papers 2
Gary D Bader
University of Toronto
Co-authored papers 2
Neil Winegarden
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 2
Frederick A Dick
Western University
Co-authored papers 2
Rod Bremner
University of Toronto
Co-authored papers 2
David Lydall
Institute for Cell and Molecular Biosciences, Newcastle University Medical School
Co-authored papers 2
Jennifer Cruickshank
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 2
Daniel Durocher
The Lunenfeld-Tannenbaum Research Institute, Mount Sinai Hospital
Co-authored papers 2
Jasmin Coulombe-Huntington
Institute for Research in Immunology and Cancer, Universite de Montreal
Co-authored papers 2
Ian D Clarke
Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
Co-authored papers 1
Richard W Wozniak
University of Alberta
Co-authored papers 1
Adrienne Rollie
Children's Hospital Los Angeles
Co-authored papers 1
Alison L Martens
Co-authored papers 1
Jeremy A Squire
University of Sao Paulo
Co-authored papers 1
Michel L Tremblay
Co-authored papers 1
Sarah Galicia
Co-authored papers 1
Aleksandar D Kostic
Co-authored papers 1
Sandrine Guillard
MedImmune Ltd.
Co-authored papers 1
David W Andrews
Sunnybrook Research Institute, University of Toronto
Co-authored papers 1
Mikhajlo K Zubko
Manchester Metropolitan University (MMU)
Co-authored papers 1
Kevin G Becker
National Institute on Aging, National Institutes of Health
Co-authored papers 1
Ivan Topisirovic
McGill University
Co-authored papers 1
Brenda J Andrews
University of Toronto
Co-authored papers 1
Rebecca Houlsworth
Co-authored papers 1
Andrew Emili
Boston University School of Medicine, Boston University
Co-authored papers 1
Ivan Sadowski
University of British Columbia
Co-authored papers 1
Susan J Done
University Health Network
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Release 1.2