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Author Details

John E Dick
Princess Margaret Cancer Centre, University Health Network
1980
238
94
PMIDPaper TitleJournal TitlePublished Year
36763002In Vivo Screening Unveils Pervasive RNA-Binding Protein Dependencies in Leukemic Stem Cells and Identifies ELAVL1 as a Therapeutic Target.Blood Cancer Discov2023
37479893Single-cell chromatin accessibility profiling of acute myeloid leukemia reveals heterogeneous lineage composition upon therapy-resistance.Commun Biol2023
37191437Distinct Assemblies of Heterodimeric Cytokine Receptors Govern Stemness Programs in Leukemia.Cancer Discov2023
37021547Simultaneous inhibition of Sirtuin 3 and cholesterol homeostasis targets acute myeloid leukemia stem cells by perturbing fatty acid β-oxidation and inducing lipotoxicity.Haematologica2023
37337105Transcriptomic classes of BCR-ABL1 lymphoblastic leukemia.Nat Genet2023
37034724Transcriptional Activation of Regenerative Hematopoiesis via Vascular Niche Sensing.bioRxiv2023
36720973KDM6 demethylases integrate DNA repair gene regulation and loss of KDM6A sensitizes human acute myeloid leukemia to PARP and BCL2 inhibition.Leukemia2023
35019858Multiomic Profiling of Central Nervous System Leukemia Identifies mRNA Translation as a Therapeutic Target.Blood Cancer Discov2022
35729851Clonal haematopoiesis is associated with higher mortality in patients with cardiogenic shock.Eur J Heart Fail2022
35668135The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal haematopoietic stem and progenitor cells to maintain stemness.Nat Cell Biol2022
35639948PLAG1 dampens protein synthesis to promote human hematopoietic stem cell self-renewal.Blood2022
35618837A cellular hierarchy framework for understanding heterogeneity and predicting drug response in acute myeloid leukemia.Nat Med2022
35971894Identification and characterization of inâ¿¿vitro expanded hematopoietic stem cells.EMBO Rep2022
35971851Clonal hematopoiesis confers an increased mortality risk in orthotopic heart transplant recipients.Am J Transplant2022
36131042A primary hierarchically organized patient-derived model enables in depth interrogation of stemness driven by the coding and non-coding genome.Leukemia2022
36087071Clinical significance of clonal hematopoiesis in the setting of autologous stem cell transplantation for lymphoma.Am J Hematol2022
35156021An improved molecular inversion probe based targeted sequencing approach for low variant allele frequency.NAR Genom Bioinform2022
35247876Reconstructing Complex Cancer Evolutionary Histories from Multiple Bulk DNA Samples Using Pairtree.Blood Cancer Discov2022
35150236SmMIP-tools: a computational toolset for processing and analysis of single-molecule molecular inversion probes-derived data.Bioinformatics2022
35142149A novel CD34-specific T-cell engager efficiently depletes acute myeloid leukemia and leukemic stem cells <i>in vitro</i> and <i>in vivo</i>.Haematologica2022
34872104A clinical laboratory-developed LSC17 stemness score assay for rapid risk assessment of patients with acute myeloid leukemia.Blood Adv2022
35263585Identification of the global miR-130a targetome reveals a role for TBL1XR1 in hematopoietic stem cell self-renewal and t(8;21) AML.Cell Rep2022
33242413The Transition from Quiescent to Activated States in Human Hematopoietic Stem Cells Is Governed by Dynamic 3D Genome Reorganization.Cell Stem Cell2021
33594052Biological and therapeutic implications of a unique subtype of NPM1 mutated AML.Nat Commun2021
34389724Interacting evolutionary pressures drive mutation dynamics and health outcomes in aging blood.Nat Commun2021
34103329Enhancer Hijacking Drives Oncogenic <i>BCL11B</i> Expression in Lineage-Ambiguous Stem Cell Leukemia.Cancer Discov2021
34099695Quantitative single-cell proteomics as a tool to characterize cellular hierarchies.Nat Commun2021
34244384Mapping the cellular origin and early evolution of leukemia in Down syndrome.Science2021
34293334Nicotinamide phosphoribosyltransferase inhibitors selectively induce apoptosis of AML stem cells by disrupting lipid homeostasis.Cell Stem Cell2021
33958784A latent subset of human hematopoietic stem cells resists regenerative stress to preserve stemness.Nat Immunol2021
34343492TFEB-mediated endolysosomal activity controls human hematopoietic stem cell fate.Cell Stem Cell2021
34228982Human, mouse, and dog bone marrow show similar mesenchymal stromal cells within a distinctive microenvironment.Exp Hematol2021
33197925CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells.Blood2021
33458693Sphingosine-1-phosphate receptor 3 potentiates inflammatory programs in normal and leukemia stem cells to promote differentiation.Blood Cancer Discov2021
32649902Human Aging Alters the Spatial Organization between CD34+ Hematopoietic Cells and Adipocytes in Bone Marrow.Stem Cell Reports2020
32086311Relapse-Fated Latent Diagnosis Subclones in Acute B Lineage Leukemia Are Drug Tolerant and Possess Distinct Metabolic Programs.Cancer Discov2020
31990679Cellular and molecular architecture of hematopoietic stem cells and progenitors in genetic models of bone marrow failure.JCI Insight2020
33298453Integration of intra-sample contextual error modeling for improved detection of somatic mutations from deep sequencing.Sci Adv2020
33147339CD200 expression marks leukemia stem cells in human AML.Blood Adv2020
32793890Mutational landscape and patterns of clonal evolution in relapsed pediatric acute lymphoblastic leukemia.Blood Cancer Discov2020
30352278Characterization of inv(3) cell line OCI-AML-20 with stroma-dependent CD34 expression.Exp Hematol2019
30089916The stem cell-associated gene expression signature allows risk stratification in pediatric acute myeloid leukemia.Leukemia2019
31175119An <i>ERG</i> Enhancer-Based Reporter Identifies Leukemia Cells with Elevated Leukemogenic Potential Driven by ERG-USP9X Feed-Forward Regulation.Cancer Res2019
31631013Sphingolipid Modulation Activates Proteostasis Programs to Govern Human Hematopoietic Stem Cell Self-Renewal.Cell Stem Cell2019
31628330Functional profiling of single CRISPR/Cas9-edited human long-term hematopoietic stem cells.Nat Commun2019
31127310High efficiency error suppression for accurate detection of low-frequency variants.Nucleic Acids Res2019
30705411A novel method for detecting the cellular stemness state in normal and leukemic human hematopoietic cells can predict disease outcome and drug sensitivity.Leukemia2019
30796022A stemness screen reveals <i>C3orf54/INKA1</i> as a promoter of human leukemia stem cell latency.Blood2019
29342133A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies.Nature2018
29988082Prediction of acute myeloid leukaemia risk in healthy individuals.Nature2018
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Collaborators

Faiyaz Notta
2Ontario Institute for Cancer Research
Co-authored papers 17
Gary D Bader
University of Toronto
Co-authored papers 16
Alex Murison
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 15
Kolja Eppert
McGill University
Co-authored papers 13
Michelle Chan-Seng-Yue
Princess Margaret Cancer Centre
Co-authored papers 13
Sergei Doulatov
University of Washington
Co-authored papers 13
Sasan Zandi
University of Toronto
Co-authored papers 13
Charles G Mullighan
St Jude Children's Research Hospital
Co-authored papers 11
John D McPherson
Ontario Institute for Cancer Research
Co-authored papers 10
Suzanne Kamel-Reid
Toronto General Hospital, University Health Network, University of Toronto
Co-authored papers 9
Peter W Zandstra
Co-authored papers 8
Mathieu Lupien
Princess Margaret Cancer Research Centre
Co-authored papers 8
Aaron D Schimmer
Princess Margaret Cancer Centre
Co-authored papers 8
Steven Gallinger
Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto
Co-authored papers 7
Jinghui Zhang
Changhai Hospital, Second Military Medical University
Co-authored papers 6
Rose Hurren
Princess Margaret Cancer Centre
Co-authored papers 6
Michael Rusch
St Jude Children's Research Hospital
Co-authored papers 6
Kathryn G Roberts
St Jude Children's Research Hospital
Co-authored papers 6
Luigi Naldini
Vita-Salute San Raffaele University
Co-authored papers 6
Marcela Gronda
Princess Margaret Cancer Centre
Co-authored papers 5
Thomas J Hudson
Ontario Institute for Cancer Research
Co-authored papers 5
Steven M Kornblau
The University of Texas MD Anderson Cancer Center
Co-authored papers 5
John Easton
St Jude Children's Research Hospital
Co-authored papers 5
Lincoln Stein
Ontario Institute for Cancer Research, University Avenue
Co-authored papers 5
Brian Raught
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 4
Andrew M K Brown
Ontario Institute for Cancer Research
Co-authored papers 4
Lawrence E Heisler
Ontario Institute for Cancer Research
Co-authored papers 4
Jeffrey L Wrana
Lunenfeld-Tanenbaum Research Institute Mount Sinai Hospital
Co-authored papers 4
Leonard D Shultz
The Jackson Laboratory Cancer Center
Co-authored papers 4
Mignon L Loh
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Release 1.2