Author details

Full Name

Deborah J Lenschow

Affiliation

ORCID

Career Start Year

1990

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
35026136	En garde! The duel functions of MORC3.		2022
35675358	Fibroblast growth factor-9 expression in airway epithelial cells amplifies the type I interferon response and alters influenza A virus pathogenesis.	PLoS Pathogens	2022
34668781	Interferon Alpha, but Not Interferon Beta, Acts Early To Control Chronic Chikungunya Virus Pathogenesis.	Journal of Virology	2022
34632326	6-Thioguanine blocks SARS-CoV-2 replication by inhibition of PLpro.	iScience	2021
32553163	Modulation of Extracellular ISG15 Signaling by Pathogens and Viral Effector Proteins.	Cell Reports	2020
32637945	6-Thioguanine blocks SARS-CoV-2 replication by inhibition of PLpro protease activities.		2020
33024031	ISG15 Connects Autophagy and IFN-Î³-Dependent Control of Toxoplasma gondii Infection in Human Cells.	mBio	2020
33408718	Context Is Key: Delineating the Unique Functions of IFNÎ± and IFNÎ² in Disease.	Frontiers in Immunology	2020
31465513	Dermal and muscle fibroblasts and skeletal myofibers survive chikungunya virus infection and harbor persistent RNA.	PLoS Pathog	2019
31619554	Distinct Roles of Interferon Alpha and Beta in Controlling Chikungunya Virus Replication and Modulating Neutrophil-Mediated Inflammation.	Journal of Virology	2019
30156437	Intracellular C3 Protects Human Airway Epithelial Cells from Stress-associated Cell Death.	American Journal of Respiratory Cell and Molecular Biology	2019
29769653	ISG15 in antiviral immunity and beyond.	Nature Reviews Microbiology	2018
29361204	Editorial: Lessons Learned From Chikungunya in the Americas.	Arthritis and Rheumatology	2018
28159534	Chikungunya virus: an update on the biology and pathogenesis of this emerging pathogen.	Lancet Infectious Diseases, The	2017
28774928	The microbial metabolite desaminotyrosine protects from influenza through type I interferon.	Science	2017
28087453	The impact of ISGylation during Mycobacterium tuberculosis infection in mice.	Microbes and Infection	2017
28148840	Therapy with CTLA4-Ig and an antiviral monoclonal antibody controls chikungunya virus arthritis.	Sci Transl Med	2017
26590325	Replication-competent fluorescent-expressing influenza B virus.	Virus Res	2016
27193971	ISG15 deficiency and increased viral resistance in humans but not mice.	Nat Commun	2016
25605621	Chikungunya viral arthritis in the United States: a mimic of seronegative rheumatoid arthritis.	Arthritis Rheumatol	2015
25320315	Novel mode of ISG15-mediated protection against influenza A virus and Sendai virus in mice.	Journal of Virology	2015
25482432	Type I interferons link viral infection to enhanced epithelial turnover and repair.		2015
25605921	Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistance.	Proceedings of the National Academy of Sciences of the United States of America	2015
25100850	A chimeric virus-mouse model system for evaluating the function and inhibition of papain-like proteases of emerging coronaviruses.	J Virol	2014
24335291	Infection of myofibers contributes to increased pathogenicity during infection with an epidemic strain of chikungunya virus.	Journal of Virology	2014
24173234	Rodent herpesvirus Peru encodes a secreted chemokine decoy receptor.	Journal of Virology	2014
24899198	ISG15 functions as an interferon-mediated antiviral effector early in the murine norovirus life cycle.	J Virol	2014
25166009	Human cytomegalovirus pUL79 is an elongation factor of RNA polymerase II for viral gene transcription.	PLoS Pathogens	2014
23364696	Identification of a candidate therapeutic autophagy-inducing peptide.	Nature	2013
24095857	The antiviral activities of ISG15.	Journal of Molecular Biology	2013
24010825	Emerging roles for immunomodulatory functions of free ISG15.	Journal of Interferon and Cytokine Research	2013
22327075	Cutting edge: paradoxical roles of BST2/tetherin in promoting type I IFN response and viral infection.	Journal of Immunology	2012
22508836	Chikungunya virus-induced autophagy delays caspase-dependent cell death.	J Exp Med	2012
22836517	Chikungunya-induced cell death is limited by ER and oxidative stress-induced autophagy.	Autophagy	2012
21934098	Pillars article: CTLA-4 can function as a negative regulator of T cell activation. Immunity. 1994. 1: 405-413.	J Immunol	2011
21847135	Increased cerebral protein ISGylation after focal ischemia is neuroprotective.	J Cereb Blood Flow Metab	2011
22028657	ISG15 is critical in the control of Chikungunya virus infection independent of UbE1L mediated conjugation.	PLoS Pathogens	2011
21994614	Antiviral Properties of ISG15.	Viruses	2010
20219937	Species-specific antagonism of host ISGylation by the influenza B virus NS1 protein.	J Virol	2010
19004958	Mice lacking the ISG15 E1 enzyme UbE1L demonstrate increased susceptibility to both mouse-adapted and non-mouse-adapted influenza B virus infection.	J Virol	2009
19073728	ISG15 Arg151 and the ISG15-conjugating enzyme UbE1L are important for innate immune control of Sindbis virus.	Journal of Virology	2009
18606809	Nitrosylation of ISG15 prevents the disulfide bond-mediated dimerization of ISG15 and contributes to effective ISGylation.	J Biol Chem	2008
18078692	Ovarian tumor domain-containing viral proteases evade ubiquitin- and ISG15-dependent innate immune responses.	Cell Host Microbe	2007
17227866	IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses.	Proc Natl Acad Sci U S A	2007
16254333	Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo.	Journal of Virology	2005
16139798	Proteomic identification of proteins conjugated to ISG15 in mouse and human cells.	Biochem Biophys Res Commun	2005
15248230	Anti-tumor necrosis factor therapy in patients with difficult to treat Takayasu arteritis.	Arthritis Rheum	2004
11798981	Polymyalgia rheumatica/temporal arteritis: recent advances.	Current Rheumatology Reports	2002
10795741	B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes.	Immunity	2000
8993020	CD28/B7 costimulation regulates autoimmune diabetes induced with multiple low doses of streptozotocin.	J Immunol	1997