Author details

Full Name

Sekar Kathiresan

Affiliation

ORCID

Career Start Year

1991

Papers

329

H Index

130

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37291107	South Asian medical cohorts reveal strong founder effects and high rates of homozygosity.	Nat Commun	2023
36314243	Efficacy and Safety of an Investigational Single-Course CRISPR Base-Editing Therapy Targeting in Nonhuman Primate and Mouse Models.	Circulation	2023
37188660	GalNAc-Lipid nanoparticles enable non-LDLR dependent hepatic delivery of a CRISPR base editing therapy.	Nat Commun	2023
34849650	Endothelial ARHGEF26 is an angiogenic factor promoting VEGF signalling.	Cardiovasc Res	2022
36048760	Neurocognitive trajectory and proteomic signature of inherited risk for Alzheimer's disease.	PLoS Genet	2022
35915156	Large-scale genome-wide association study of coronary artery disease in genetically diverse populations.	Nat Med	2022
35234888	Genetic and clinical determinants of abdominal aortic diameter: genome-wide association studies, exome array data and Mendelian randomization study.	Hum Mol Genet	2022
34750571	Integrative analysis of the plasma proteome and polygenic risk of cardiometabolic diseases.	Nat Metab	2021
34176299	Coronary Disease Association With ADAMTS7 Is Due to Protease Activity.	Circ Res	2021
33536627	Author Correction: A structural variation reference for medical and population genetics.	Nature	2021
34012082	In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates.	Nature	2021
33846329	Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices.	Nat Commun	2021
34050697	Clonal hematopoiesis associated with epigenetic aging and clinical outcomes.	Aging Cell	2021
33822779	Correction: A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease.	PLoS Genet	2021
33976420	Randomized prospective evaluation of genome sequencing versus standard-of-care as a first molecular diagnostic test.	Genet Med	2021
33310085	Association of Genetic Variation With Cirrhosis: A Multi-Trait Genome-Wide Association and Gene-Environment Interaction Study.	Gastroenterology	2021
33284643	Transethnic Transferability of a Genome-Wide Polygenic Score for Coronary Artery Disease.	Circ Genom Precis Med	2021
33115266	Lp(a) (Lipoprotein[a]) Concentrations and Incident Atherosclerotic Cardiovascular Disease: New Insights From a Large National Biobank.	Arterioscler Thromb Vasc Biol	2021
34611364	A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response.	Nat Genet	2021
34592835	Rare, Damaging DNA Variants in and Risk of Coronary Artery Disease: Insights From Functional Genomics and Large-Scale Sequencing Analyses.	Circulation. Genomic and precision medicine	2021
32498804	Limitations of Contemporary Guidelines for Managing Patients at High Genetic Risk of Coronary Artery Disease.	J Am Coll Cardiol	2020
31898914	Genome-Wide Polygenic Score and Cardiovascular Outcomes With Evacetrapib in Patients With High-Risk Vascular Disease: A Nested Case-Control Study.	Circulation. Genomic and precision medicine	2020
32347951	Association of Rare Pathogenic DNA Variants for Familial Hypercholesterolemia, Hereditary Breast and Ovarian Cancer Syndrome, and Lynch Syndrome With Disease Risk in Adults According to Family History.	JAMA Netw Open	2020
32164899	Titin Truncating Variants in Adults Without Known Congestive HeartÂ Failure.	J Am Coll Cardiol	2020
32277781	Genetically Elevated LDL Associates with Lower Risk of Intracerebral Hemorrhage.	Ann Neurol	2020
32213464	EDEM3 Modulates Plasma Triglyceride Level through Its Regulation of LRP1 Expression.	iScience	2020
31707836	Genetic Interleukin 6 Signaling Deficiency Attenuates Cardiovascular Risk in Clonal Hematopoiesis.	Circulation	2020
32470373	Non-parametric Polygenic Risk Prediction via Partitioned GWAS Summary Statistics.	Am J Hum Genet	2020
32382064	Analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy.	Nat Commun	2020
31915397	A brief history of human disease genetics.	Nature	2020
32762905	Validation of a Genome-Wide PolygenicÂ Score for Coronary ArteryÂ Disease inÂ South Asians.	J Am Coll Cardiol	2020
32820175	Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions.	Nat Commun	2020
32981348	Genetic Architecture of Abdominal Aortic Aneurysm in the Million Veteran Program.	Circulation	2020
32862661	Heterozygous <i>ABCG5</i> Gene Deficiency and Risk of Coronary Artery Disease.	Circ Genom Precis Med	2020
33339817	Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease.	Nat Commun	2020
32957805	Genome-Wide Polygenic Score, Clinical Risk Factors, and Long-Term Trajectories of Coronary Artery Disease.	Arterioscler Thromb Vasc Biol	2020
32786677	Interactomics Analyses of Wild-Type and Mutant A1CF Reveal Diverged Functions in Regulating Cellular Lipid Metabolism.	J Proteome Res	2020
31146585	Single-Cell Analysis of the Normal Mouse Aorta Reveals Functionally Distinct Endothelial Cell Populations.	Circulation	2019
31727422	Rare Genetic Variants Associated With Sudden Cardiac Death in Adults.	J Am Coll Cardiol	2019
31771638	Low coverage whole genome sequencing enables accurate assessment of common variants and calculation of genome-wide polygenic scores.	Genome Med	2019
31558144	Leveraging Human Genetics to Estimate Clinical Risk Reductions Achievable by Inhibiting Factor XI.	Stroke	2019
30270359	Recall by genotype and cascade screening for familial hypercholesterolemia in a population-based biobank from Estonia.	Genet Med	2019
30586733	Whole-Genome Sequencing to Characterize Monogenic and Polygenic Contributions in Patients Hospitalized With Early-Onset Myocardial Infarction.	Circulation	2019
30389748	DNA Sequence Variation in <i>ACVR1C</i> Encoding the Activin Receptor-Like Kinase 7 Influences Body Fat Distribution and Protects Against Type 2 Diabetes.	Diabetes	2019
31285632	Genome-wide association study of peripheral artery disease in the Million Veteran Program.	Nat Med	2019
31160809	Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.	Nat Genet	2019
30901535	Genetics of Common, Complex Coronary Artery Disease.	Cell	2019
30849324	2018 Curt Stern Award Address.	American Journal of Human Genetics	2019
31002795	Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood.	Cell	2019
31337231	Association of <i>APOL1</i> Risk Alleles With Cardiovascular Disease in Blacks in the Million Veteran Program.	Circulation	2019