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Author Details

Owen N Witte
University of California los angeles
1972
400
118
PMIDPaper TitleJournal TitlePublished Year
37399401The RNA-binding proteins hnRNP H and F regulate splicing of a MYC-dependent HRAS exon in prostate cancer cells.Proc Natl Acad Sci U S A2023
37963244Dual-inhibitory domain iCARs improve the efficiency of the AND-NOT gate CAR T strategy.Proc Natl Acad Sci U S A2023
37995683Temporal evolution reveals bifurcated lineages in aggressive neuroendocrine small cell prostate cancer trans-differentiation.Cancer Cell2023
38089570Wild-type C-Raf gene dosage and dimerization drive prostate cancer metastasis.iScience2023
37192158IRIS: Discovery of cancer immunotherapy targets arising from pre-mRNA alternative splicing.Proc Natl Acad Sci U S A2023
37289025The Genomic and Epigenomic Landscape of Double-Negative Metastatic Prostate Cancer.Cancer Res2023
36251389The 5-Hydroxymethylcytosine Landscape of Prostate Cancer.Cancer Res2022
36109521Transcriptional profiling of matched patient biopsies clarifies molecular determinants of enzalutamide-induced lineage plasticity.Nat Commun2022
35878026Physical and in silico immunopeptidomic profiling of a cancer antigen prostatic acid phosphatase reveals targets enabling TCR isolation.Proc Natl Acad Sci U S A2022
33431692Droplet-based mRNA sequencing of fixed and permeabilized cells by CLInt-seq allows for antigen-specific TCR cloning.Proc Natl Acad Sci U S A2021
33711255RNA Dysregulation: An Expanding Source of Cancer Immunotherapy Targets.Trends Pharmacol Sci2021
34919800HLA-A<sup>⿿</sup>02:01 restricted T cell receptors against the highly conserved SARS-CoV-2 polymerase cross-react with human coronaviruses.Cell Rep2021
32424106Transcriptional profiling identifies an androgen receptor activity-low, stemness program associated with enzalutamide resistance.Proc Natl Acad Sci U S A2020
32086391Pathway-guided analysis identifies Myc-dependent alternative pre-mRNA splicing in aggressive prostate cancers.Proc Natl Acad Sci U S A2020
31871155A genetically defined disease model reveals that urothelial cells can initiate divergent bladder cancer phenotypes.Proc Natl Acad Sci U S A2020
31653711<sup>18</sup>F-FAC PET Visualizes Brain-Infiltrating Leukocytes in a Mouse Model of Multiple Sclerosis.J Nucl Med2020
32461304Targeting RET Kinase in Neuroendocrine Prostate Cancer.Mol Cancer Res2020
30409823IND-Enabling Studies for a Clinical Trial to Genetically Program a Persistent Cancer-Targeted Immune System.Clin Cancer Res2019
31801883Targeting cellular heterogeneity with CXCR2 blockade for the treatment of therapy-resistant prostate cancer.Sci Transl Med2019
31495780Development of Hematopoietic Stem Cell-Engineered Invariant Natural Killer T Cell Therapy for Cancer.Cell Stem Cell2019
31287989Pan-cancer Convergence to a Small-Cell Neuroendocrine Phenotype that Shares Susceptibilities with Hematological Malignancies.Cancer Cell2019
31484081Sensitive Detection and Analysis of Neoantigen-Specific T Cell Populations from Tumors and Blood.Cell Rep2019
30804427MEK-ERK signaling is a therapeutic target in metastatic castration resistant prostate cancer.Prostate Cancer Prostatic Dis2019
30700903T cell antigen discovery via trogocytosis.Nat Methods2019
29686080Systemic surfaceome profiling identifies target antigens for immune-based therapy in subtypes of advanced prostate cancer.Proc Natl Acad Sci U S A2018
30232014A Human Adult Stem Cell Signature Marks Aggressive Variants across Epithelial Cancers.Cell Rep2018
29985747Clinical and Genomic Characterization of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer: A Multi-institutional Prospective Study.J Clin Oncol2018
30033370Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer.Cell2018
30348802Isolation and characterization of NY-ESO-1-specific T cell receptors restricted on various MHC molecules.Proc Natl Acad Sci U S A2018
30287662Reprogramming normal human epithelial tissues to a common, lethal neuroendocrine cancer lineage.Science2018
30340047Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer.Cell2018
29700125<sup>18</sup>F-FAC PET Selectively Images Liver-Infiltrating CD4 and CD8 T Cells in a Mouse Model of Autoimmune Hepatitis.J Nucl Med2018
29496991Noninvasive Imaging of Drug-Induced Liver Injury with <sup>18</sup>F-DFA PET.J Nucl Med2018
28621319FOXA2 is a sensitive and specific marker for small cell neuroendocrine carcinoma of the prostate.Mod Pathol2017
28190001Genetic analysis of Ikaros target genes and tumor suppressor function in BCR-ABL1<sup>+</sup> pre-B ALL.J Exp Med2017
27050099N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells.Cancer Cell2016
28723508Targeting Adaptive Pathways in Metastatic Treatment-Resistant Prostate Cancer: Update on the Stand Up 2 Cancer/Prostate Cancer Foundation-Supported West Coast Prostate Cancer Dream Team.Eur Urol Focus2016
26573799An Effective Immuno-PET Imaging Method to Monitor CD8-Dependent Responses to Immunotherapy.Cancer Res2016
26621741Functional screen identifies kinases driving prostate cancer visceral and bone metastasis.Proc Natl Acad Sci U S A2016
27926864Low CD38 Identifies Progenitor-like Inflammation-Associated Luminal Cells that Can Initiate Human Prostate Cancer and Predict Poor Outcome.Cell Rep2016
27694579Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer.Proc Natl Acad Sci U S A2016
27235684Advances in PET Detection of the Antitumor T Cell Response.Adv Immunol2016
27499020Phosphoproteome Integration Reveals Patient-Specific Networks in Prostate Cancer.Cell2016
27044116Prostate epithelial cell of origin determines cancer differentiation state in an organoid transformation assay.Proc Natl Acad Sci U S A2016
27035974[18F]CFA as a clinically translatable probe for PET imaging of deoxycytidine kinase activity.Proc Natl Acad Sci U S A2016
25605948Genetic engineering of hematopoietic stem cells to generate invariant natural killer T cells.Proc Natl Acad Sci U S A2015
26631129Tissue Recombination Models for the Study of Epithelial Cancer.Cold Spring Harb Protoc2015
26542560Lift NIH restrictions on chimera research.Science2015
26460041A basal stem cell signature identifies aggressive prostate cancer phenotypes.Proc Natl Acad Sci U S A2015
26527760Dissociated Prostate Regeneration under the Renal Capsule.Cold Spring Harb Protoc2015
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Collaborators

Jami McLaughlin
University of California los angeles
Co-authored papers 44
Donghui Cheng
University of California los angeles
Co-authored papers 43
Jiaoti Huang
Duke University School of Medicine
Co-authored papers 35
Andrew S Goldstein
University of California los angeles
Co-authored papers 23
Robert E Reiter
David Geffen School of Medicine at university of california los angeles
Co-authored papers 19
Antoni Ribas
University of California Los Angeles (university of california los angeles)
Co-authored papers 17
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Memorial Sloan Kettering Cancer Center
Co-authored papers 14
Matthew B Rettig
David Geffen School of Medicine, University of California los angeles
Co-authored papers 11
Martin E Gleave
University of British Columbia
Co-authored papers 11
James R Heath
Institute of Systems Biology, University of Washington
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Joshua M Stuart
University of California at Santa Cruz
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University of California San Francisco
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University of California Davis
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University of California San Francisco
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UCSF Medical Center-Mount Zion
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Tomasz M Beer
OHSU Knight Cancer Institute, Oregon Health & Science University
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John W Phillips
University of California los angeles
Co-authored papers 9
Eric J Small
University of California san francisco
Co-authored papers 9
Adam Foye
University of California San Francisco
Co-authored papers 8
Thomas J George
UF Health Cancer Center
Co-authored papers 7
Johannes Czernin
university of california los angeles
Co-authored papers 7
Kim N Chi
University of British Columbia
Co-authored papers 6
David A Quigley
University of California-San Francisco
Co-authored papers 6
Primo N Lara
University of California Davis Comprehensive Cancer Center
Co-authored papers 6
Nathanael J Bangayan
University of California los angeles
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Vladislav Uzunangelov
University of California
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James A Wohlschlegel
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Release 1.2