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Author Details

Daniel R Southworth
The Institute for Neurodegenerative Diseases, University of California San Francisco
2002
58
30
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36753572Chemical Features of Polyanions Modulate Tau Aggregation and Conformational States.J Am Chem Soc2023
37945741The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions.Nat Struct Mol Biol2023
37611827Structural insights of the p97/VCP AAA+ ATPase: How adapter interactions coordinate diverse cellular functionality.J Biol Chem2023
37236970Stacked binding of a PET ligand to Alzheimer's tau paired helical filaments.Nat Commun2023
37330289The E3 Ubiquitin Ligase, CHIP/STUB1, Inhibits Aggregation of Phosphorylated Proteoforms of Microtubule-associated Protein Tau (MAPT).J Mol Biol2023
37293102Asymmetric apical domain states of mitochondrial Hsp60 coordinate substrate engagement and chaperonin assembly.bioRxiv2023
37292947The p97/VCP adapter UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions.bioRxiv2023
34492227Assembly principles of the human R2TP chaperone complex reveal the presence of R2T and R2P complexes.Structure2022
34031651CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.Res Sq2021
34380015The structure of an Hsp90-immunophilin complex reveals cochaperone recognition of the client maturation state.Mol Cell2021
34013269CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.bioRxiv2021
32313240Conformational plasticity of the ClpAP AAA+ protease couples protein unfolding and proteolysis.Nat Struct Mol Biol2020
33060197Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.Science2020
31160557Structural basis for substrate gripping and translocation by the ClpB AAA+ disaggregase.Nat Commun2019
31533964Mechanistic insights into the protective roles of polyphosphate against amyloid cytotoxicity.Life Sci Alliance2019
31433984Mining Disaggregase Sequence Space to Safely Counter TDP-43, FUS, and α-Synuclein Proteotoxicity.Cell Rep2019
31578281Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation.J Biol Chem2019
30737390Chaperone activation and client binding of a 2-cysteine peroxiredoxin.Nat Commun2019
31056463Allosteric Regulation of Oligomerization by a B<sub>12</sub> Trafficking G-Protein Is Corrupted in Methylmalonic Aciduria.Cell Chem Biol2019
30745294Spiraling in Control: Structures and Mechanisms of the Hsp104 Disaggregase.Cold Spring Harb Perspect Biol2019
29255093X-linked inhibitor of apoptosis protein (XIAP) is a client of heat shock protein 70 (Hsp70) and a biomarker of its inhibition.J Biol Chem2018
30130556Polyphosphate Stabilizes Protein Unfolding Intermediates as Soluble Amyloid-like Oligomers.J Mol Biol2018
29941666Chaperone Activity and Dimerization Properties of Hsp90<i>α</i> and Hsp90<i>β</i> in Glucocorticoid Receptor Activation by the Multiprotein Hsp90/Hsp70-Dependent Chaperone Machinery.Mol Pharmacol2018
30385828Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau.Nat Commun2018
29618513The full-length cytochrome P450 enzyme CYP102A1 dimerizes at its reductase domains and has flexible heme domains for efficient catalysis.J Biol Chem2018
27884606BAG3 Is a Modular, Scaffolding Protein that physically Links Heat Shock Protein 70 (Hsp70) to the Small Heat Shock Proteins.J Mol Biol2017
28303570Aggregation of Mod5 is affected by tRNA binding with implications for tRNA gene-mediated silencing.FEBS Lett2017
28882898Switch I-dependent allosteric signaling in a G-protein chaperone-B<sub>12</sub> enzyme complex.J Biol Chem2017
28619716Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104.Science2017
27112599Architecture and Nucleotide-Dependent Conformational Changes of the Rvb1-Rvb2 AAA+ Complex Revealed by Cryoelectron Microscopy.Structure2016
26611544Single-particle cryo-electron microscopy of macromolecular complexes.Microscopy (Oxf)2016
27478928Spiral architecture of the Hsp104 disaggregase reveals the basis for polypeptide translocation.Nat Struct Mol Biol2016
27570072Polyphosphate: A Conserved Modifier of Amyloidogenic Processes.Mol Cell2016
25783003Enhancement of dynamin polymerization and GTPase activity by Arc/Arg3.1.Biochim Biophys Acta2015
26565746Specific Binding of Tetratricopeptide Repeat Proteins to Heat Shock Protein 70 (Hsp70) and Heat Shock Protein 90 (Hsp90) Is Regulated by Affinity and Phosphorylation.Biochemistry2015
25962097A conserved histidine modulates HSPB5 structure to trigger chaperone activity in response to stress-related acidosis.Elife2015
25646478Mitochondrial peroxiredoxin functions as crucial chaperone reservoir in Leishmania infantum.Proc Natl Acad Sci U S A2015
24327656The molecular chaperone Hsp70 activates protein phosphatase 5 (PP5) by binding the tetratricopeptide repeat (TPR) domain.J Biol Chem2014
25242142The protein targeting factor Get3 functions as ATP-independent chaperone under oxidative stress conditions.Mol Cell2014
24737326Architecture of the nitric-oxide synthase holoenzyme reveals large conformational changes and a calmodulin-driven release of the FMN domain.J Biol Chem2014
24949977Glucocorticoid receptor function regulated by coordinated action of the Hsp90 and Hsp70 chaperone cycles.Cell2014
24709419KRAS protein stability is regulated through SMURF2: UBCH5 complex-mediated β-TrCP1 degradation.Neoplasia2014
23865999The E3 ubiquitin ligase CHIP and the molecular chaperone Hsc70 form a dynamic, tethered complex.Biochemistry2013
22653663The conserved arginine 380 of Hsp90 is not a catalytic residue, but stabilizes the closed conformation required for ATP hydrolysis.Protein Sci2012
21405358High-Q nanomechanics via destructive interference of elastic waves.Phys Rev Lett2011
21700222Client-loading conformation of the Hsp90 molecular chaperone revealed in the cryo-EM structure of the human Hsp90:Hop complex.Mol Cell2011
20680089Real-time synchronous imaging of electromechanical resonator mode and equilibrium profiles.Opt Lett2010
19554567Grp94, the endoplasmic reticulum Hsp90, has a similar solution conformation to cytosolic Hsp90 in the absence of nucleotide.Protein Sci2009
19658878Stress and silicon nitride: a crack in the universal dissipation of glasses.Phys Rev Lett2009
19427321pH-dependent conformational changes in bacterial Hsp90 reveal a Grp94-like conformation at pH 6 that is highly active in suppression of citrate synthase aggregation.J Mol Biol2009
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Collaborators

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Co-authored papers 11
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College of Chemistry, Jilin University
Co-authored papers 3
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 3
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Co-authored papers 3
University of California San Francisco
Co-authored papers 3
Fred Hutchinson Cancer Center
Co-authored papers 3
Fred Hutchinson Cancer Center
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University of California San Francisco (UCSF) School of Medicine
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