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Author Details

Omid Tavana
Oncology R&D
2010
27
17
PMIDPaper TitleJournal TitlePublished Year
37024504Targeting USP2 regulation of VPRBP-mediated degradation of p53 and PD-L1 for cancer therapy.Nat Commun2023
34750098Systematic Pan-Cancer Characterization of Nuclear Receptors Identifies Potential Cancer Biomarkers and Therapeutic Targets.Cancer Res2022
35487975Deciphering the acetylation code of p53 in transcription regulation and tumor suppression.Oncogene2022
35121907The Cancer Surfaceome Atlas integrates genomic, functional and drug response data to identify actionable targets.Nat Cancer2021
32988967AZD4320, A Dual Inhibitor of Bcl-2 and Bcl-x<sub>L</sub>, Induces Tumor Regression in Hematologic Cancer Models without Dose-limiting Thrombocytopenia.Clin Cancer Res2020
32803978Discovery of Proteolysis-Targeting Chimera Molecules that Selectively Degrade the IRAK3 Pseudokinase.J Med Chem2020
30962574ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway.Nat Cell Biol2019
31282934p53 modifications: exquisite decorations of the powerful guardian.J Mol Cell Biol2019
30709928The Deubiquitylase OTUB1 Mediates Ferroptosis via Stabilization of SLC7A11.Cancer Res2019
29482658Independent functions of DNMT1 and USP7 at replication foci.Epigenetics Chromatin2018
30250887ARF-NRF2: A new checkpoint for oxidative stress responses?Mol Cell Oncol2018
29616860Targeting HAUSP in both p53 wildtype and p53-mutant tumors.Cell Cycle2018
29523541Peli1 Modulates the Subcellular Localization and Activity of Mdmx.Cancer Res2018
27927749Modulation of the p53/MDM2 interplay by HAUSP inhibitors.J Mol Cell Biol2017
28406743The "readers" of unacetylated p53 represent a new class of acidic domain proteins.Nucleus2017
28985506NRF2 Is a Major Target of ARF in p53-Independent Tumor Suppression.Mol Cell2017
27618649HAUSP deubiquitinates and stabilizes N-Myc in neuroblastoma.Nat Med2016
23752193A novel Ku70 function in colorectal homeostasis separate from nonhomologous end joining.Oncogene2014
24419106Controlling ARF stability: new players added to the team.Cell Cycle2014
23255100p53 and DNA methylation suppress the TRAIN to cell death.Cell Cycle2013
23395165The Hunger Games: p53 regulates metabolism upon serine starvation.Cell Metab2013
23474484Ku70 functions in addition to nonhomologous end joining in pancreatic β-cells: a connection to β-catenin regulation.Diabetes2013
22698404p53-mediated senescence impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer.Cancer Cell2012
21750406Too many breaks (brakes): pancreatic β-cell senescence leads to diabetes.Cell Cycle2011
19833883Absence of p53-dependent apoptosis combined with nonhomologous end-joining deficiency leads to a severe diabetic phenotype in mice.Diabetes2010
19915617ATM and p53 are essential in the cell-cycle containment of DNA breaks during V(D)J recombination in vivo.Oncogene2010
20703098Absence of p53-dependent apoptosis leads to UV radiation hypersensitivity, enhanced immunosuppression and cellular senescence.Cell Cycle2010
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Collaborators

Adel K El-Naggar
MD Anderson Cancer Center
Co-authored papers 1
Gareth P Gregory
School of Clinical Sciences at Monash Health, Monash University
Co-authored papers 1
Shenghua Wen
Oncology R&D
Co-authored papers 1
Mathew J Garnett
Wellcome Sanger Institute
Co-authored papers 1
Michael Zinda
Repare Therapeutics Inc.
Co-authored papers 1
William McCoull
Oncology R&D
Co-authored papers 1
Robert B Diebold
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Co-authored papers 1
Kate F Byth
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Co-authored papers 1
Justin Cidado
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Co-authored papers 1
Terry MacIntyre
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Paula Lewis
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Melanie Dujka
University of Texas MD Anderson Cancer Center
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Deborah Lawson
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Nancy Su
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Alwin G Schuller
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Andrea Califano
Columbia University
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Stephen Fawell
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Shannon K McWeeney
Oregon Health & Science University, University of California Berkeley
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Patricia Jaaks
Wellcome Sanger Institute
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Martin Wild
Oncology R&D
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Tong Liu
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Timothy H Bestor
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Stephanos Ioannidis
H3 Biomedicine Inc.
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Steven W Criscione
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Co-authored papers 1
Kathleen Burke
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Ricky W Johnstone
The University of Melbourne
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Edward J Hennessy
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Areya Tabatabai
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Co-authored papers 1
Eric Gangl
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Andrea Newbold
Peter MacCallum Cancer Centre
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Release 1.2