Author details

Full Name

George K Gittes

Affiliation

ORCID

Career Start Year

1982

Papers

204

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37545896	Intra-amniotic sildenafil treatment improves lung blood flow and pulmonary hypertension in congenital diaphragmatic hernia rats.		2023
37572794	Biliary atresia is associated with polygenic susceptibility in ciliogenesis and planar polarity effector genes.	J Hepatol	2023
37277426	Chemical pancreatectomy in non-human primates ablates the acini and ducts and enhances beta-cell function.		2023
37140984	Time-dependent effects of endogenous hyperglucagonemia on glucose homeostasis and hepatic glucagon action.		2023
37080362	Intra-amniotic sildenafil administration in rabbits: Safety, pharmacokinetics, organ distribution and histologic evaluation.		2023
36706177	Ionizable lipid nanoparticles deliver mRNA to pancreatic Î² cells via macrophage-mediated gene transfer.		2023
36945494	Chemical pancreatectomy in non-human primates ablates the acini and ducts and enhances beta-cell function.		2023
36733483	Bone-marrow derived cells do not contribute to new beta-cells in the inflamed pancreas.		2023
36538602	Roles of Pancreatic Islet Catecholamine Neurotransmitters in Glycemic Control and in Antipsychotic Drug-Induced Dysglycemia.		2023
36849558	A neurodevelopmental epigenetic programme mediated by SMARCD3-DAB1-Reelin signalling is hijacked to promote medulloblastoma metastasis.	Nat Cell Biol	2023
35546452	Polarized macrophages promote gestational beta cell growth through extracellular signal-regulated kinase 5 signalling.	Diabetes, Obesity and Metabolism	2022
36017799	Focal adhesion kinase-mediated signaling controls the onset of pancreatic cell differentiation.	Development (Cambridge)	2022
34582892	Î²-cell Smad2 null mice have improved Î²-cell function and are protected from diet-induced hyperglycemia.	Journal of Biological Chemistry	2021
33906911	Conversion of Î±-Cells to Î²-Cells in the Postpartum Mouse Pancreas Involves Lgr5 Progeny.		2021
34228644	Chitinase-3-like 1 protein complexes modulate macrophage-mediated immune suppression in glioblastoma.	J Clin Invest	2021
33820959	Insulin-positive ductal cells do not migrate into preexisting islets during pregnancy.	Experimental and Molecular Medicine	2021
33239450	Glucagon Resistance and Decreased Susceptibility to Diabetes in a Model of Chronic Hyperglucagonemia.		2021
33351784	Chemical pancreatectomy treats chronic pancreatitis while preserving endocrine function in preclinical models.	J Clin Invest	2021
34661584	Pancreatic Duct Infusion: An Effective and Selective Method of Drug and Viral Delivery.	Journal of Visualized Experiments	2021
34882233	Alpha-to-beta cell trans-differentiation for treatment of diabetes.	Biochemical Society Transactions	2021
34366878	Mechanisms of Impaired Lung Development and Ciliation in Mannosidase-1-Alpha-2 (<i>Man1a2</i>) Mutants.	Front Physiol	2021
32663823	Intra-Amniotic Sildenafil Treatment Promotes Lung Growth and Attenuates Vascular Remodeling in an Experimental Model of Congenital Diaphragmatic Hernia.	Fetal Diagnosis and Therapy	2020
32144129	Placental growth factor in beta cells plays an essential role in gestational beta-cell growth.	BMJ Open Diabetes Research and Care	2020
32122971	SMAD7 enhances adult Î²-cell proliferation without significantly affecting Î²-cell function in mice.	Journal of Biological Chemistry	2020
33192543	Biliary-Atresia-Associated Mannosidase-1-Alpha-2 Gene Regulates Biliary and Ciliary Morphogenesis and Laterality.	Front Physiol	2020
30783986	Simplified Purification of AAV and Delivery to the Pancreas by Intraductal Administration.	Methods Mol Biol	2019
31620668	Cellular Autophagy in Cells Plays a Role in the Maintenance of Islet Architecture.	Journal of the Endocrine Society	2019
31160417	Evidence of a developmental origin for Î²-cell heterogeneity using a dual lineage-tracing technology.	Development (Cambridge)	2019
31395607	Prolactin Promotes Fibrosis and Pancreatic Cancer Progression.	Cancer Research	2019
29304344	Endogenous Reprogramming of Alpha Cells into Beta Cells, Induced by Viral Gene Therapy, Reverses Autoimmune Diabetes.	Cell Stem Cell	2018
30613274	Islet Î±-cell Inflammation Induced By NF-ÎºB inducing kinase (NIK) Leads to Hypoglycemia, Pancreatitis, Growth Retardation, and Postnatal Death in Mice.	Theranostics	2018
28090570	Targeted inhibition of pancreatic acinar cell calcineurin is a novel strategy to prevent post-ERCP pancreatitis.	Cell Mol Gastroenterol Hepatol	2017
28775125	SMAD3/Stat3 Signaling Mediates Î²-Cell Epithelial-Mesenchymal Transition in Chronic Pancreatitis-Related Diabetes.	Diabetes	2017
28884202	Gcg <sup>CreERT2</sup> knockin mice as a tool for genetic manipulation in pancreatic alpha cells.	Diabetologia	2017
28831150	GLP-1/Exendin-4 induces Î²-cell proliferation via the epidermal growth factor receptor.	Scientific Reports	2017
29180700	Autophagy protects pancreatic beta cell mass and function in the setting of a high-fat and high-glucose diet.	Scientific Reports	2017
29235528	Identification of Newly Committed Pancreatic Cells in the Adult Mouse Pancreas.	Sci Rep	2017
29106387	Loss of mTORC1 signaling alters pancreatic Î± cell mass and impairs glucagon secretion.	Journal of Clinical Investigation	2017
28057752	Forkhead Box Protein 1 (FoxO1) Inhibits Accelerated Î² Cell Aging in Pancreas-specific SMAD7 Mutant Mice.	J Biol Chem	2017
27587395	Epidermal Growth Factor Receptor Signaling Regulates Î² Cell Proliferation in Adult Mice.	Journal of Biological Chemistry	2016
27105622	A synopsis of factors regulating beta cell development and beta cell mass.	Cellular and Molecular Life Sciences	2016
26884345	PNA lectin for purifying mouse acinar cells from the inflamed pancreas.	Scientific Reports	2016
26969166	Peroxisome Proliferator-activated Receptor-Î³ Coactivator 1-Î± (PGC1Î±) Protects against Experimental Murine Colitis.	Journal of Biological Chemistry	2016
26872091	Transient Suppression of TGFÎ² Receptor Signaling Facilitates Human Islet Transplantation.	Endocrinology	2016
27226540	Effect of Hypertriglyceridemia on Beta Cell Mass and Function in ApoC3 Transgenic Mice.	Journal of Biological Chemistry	2016
26727107	FoxO1 Plays an Important Role in Regulating Î²-Cell Compensation for Insulin Resistance in Male Mice.	Endocrinology	2016
26773130	Dynamic imaging of pancreatic nuclear factor ÎºB (NF-ÎºB) activation in live mice using adeno-associated virus (AAV) infusion and bioluminescence.	J Biol Chem	2016
26608971	Multiple roles for TGFÎ² receptor type II in regulating the pancreatic response in acute pancreatitis.	Journal of Pathology	2016
26505114	Intraislet Pancreatic Ducts Can Give Rise to Insulin-Positive Cells.	Endocrinology	2016
26379158	The Role of ARF6 in Biliary Atresia.	PLoS One	2015