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Author Details
Full Name
Xiaomin Liang
Affiliation
Gilead Sciences Inc.
ORCID
Career Start Year
2014
Papers
20
H Index
14
Expertise
CM4AI Collaborator
Andrej Sali (CM4AI)
PMID
Paper Title
Journal Title
Published Year
36540952
Predicting changes in the pharmacokinetics of CYP3A-metabolized drugs in hepatic impairment and insights into factors driving these changes.
CPT Pharmacometrics Syst Pharmacol
2023
36002079
The next frontier in ADME science: Predicting transporter-based drug disposition, tissue concentrations and drug-drug interactions in humans.
Pharmacol Ther
2022
35600889
Natural Compound ZINC12899676 Reduces Porcine Epidemic Diarrhea Virus Replication by Inhibiting the Viral NTPase Activity.
Front Pharmacol
2022
35561119
Transporters in Drug Development: International Transporter Consortium Update on Emerging Transporters of Clinical Importance.
Clin Pharmacol Ther
2022
34058067
Application of a PBPK model to elucidate the changes of systemic and liver exposures for rosuvastatin, carotegrast, and bromfenac followed by OATP inhibition in monkeys.
Clin Transl Sci
2021
33793347
Overcoming the shortcomings of the extended-clearance concept: a framework for developing a physiologically-based pharmacokinetic (PBPK) model to select drug candidates involving transporter-mediated clearance.
Expert Opin Drug Metab Toxicol
2021
33037043
In Vitro Hepatic Uptake in Human and Monkey Hepatocytes in the Presence and Absence of Serum Protein and Its In Vitro to In Vivo Extrapolation.
Drug Metab Dispos
2020
29659562
Organic cation transporter 1 (OCT1) modulates multiple cardiometabolic traits through effects on hepatic thiamine content.
PLoS Biol
2018
27856528
In Vivo Hepatic Enhancer Elements in the Human ABCG2 Locus.
Drug Metab Dispos
2017
28230985
Discovery of Competitive and Noncompetitive Ligands of the Organic Cation Transporter 1 (OCT1; SLC22A1).
J Med Chem
2017
28385543
Rosuvastatin Pharmacokinetics in Asian and White Subjects Wild Type for Both OATP1B1 and BCRP Under Control and Inhibited Conditions.
J Pharm Sci
2017
28495567
Transporters Involved in Metformin Pharmacokinetics and Treatment Response.
J Pharm Sci
2017
27803021
Interaction of 2,4-Diaminopyrimidine-Containing Drugs Including Fedratinib and Trimethoprim with Thiamine Transporters.
Drug Metab Dispos
2017
27378919
Pharmacometabolomic Assessment of Metformin in Non-diabetic, African Americans.
Front Pharmacol
2016
27447836
Metabolomic and Genome-wide Association Studies Reveal Potential Endogenous Biomarkers for OATP1B1.
Clin Pharmacol Ther
2016
25676789
Genome-wide association study identifies ABCG2 (BCRP) as an allopurinol transporter and a determinant of drug response.
Clin Pharmacol Ther
2015
26528626
Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3).
Mol Pharm
2015
25920679
Targeted disruption of organic cation transporter 3 attenuates the pharmacologic response to metformin.
Mol Pharmacol
2015
24961373
OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin.
Proc Natl Acad Sci U S A
2014
24853734
Genetic variants in transcription factors are associated with the pharmacokinetics and pharmacodynamics of metformin.
Clin Pharmacol Ther
2014
1 - 20 of 20
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