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Author Details

Xiaomin Liang
Gilead Sciences Inc.
2014
20
14
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36540952Predicting changes in the pharmacokinetics of CYP3A-metabolized drugs in hepatic impairment and insights into factors driving these changes.CPT Pharmacometrics Syst Pharmacol2023
36002079The next frontier in ADME science: Predicting transporter-based drug disposition, tissue concentrations and drug-drug interactions in humans.Pharmacol Ther2022
35600889Natural Compound ZINC12899676 Reduces Porcine Epidemic Diarrhea Virus Replication by Inhibiting the Viral NTPase Activity.Front Pharmacol2022
35561119Transporters in Drug Development: International Transporter Consortium Update on Emerging Transporters of Clinical Importance.Clin Pharmacol Ther2022
34058067Application of a PBPK model to elucidate the changes of systemic and liver exposures for rosuvastatin, carotegrast, and bromfenac followed by OATP inhibition in monkeys.Clin Transl Sci2021
33793347Overcoming the shortcomings of the extended-clearance concept: a framework for developing a physiologically-based pharmacokinetic (PBPK) model to select drug candidates involving transporter-mediated clearance.Expert Opin Drug Metab Toxicol2021
33037043In Vitro Hepatic Uptake in Human and Monkey Hepatocytes in the Presence and Absence of Serum Protein and Its In Vitro to In Vivo Extrapolation.Drug Metab Dispos2020
29659562Organic cation transporter 1 (OCT1) modulates multiple cardiometabolic traits through effects on hepatic thiamine content.PLoS Biol2018
27856528In Vivo Hepatic Enhancer Elements in the Human ABCG2 Locus.Drug Metab Dispos2017
28230985Discovery of Competitive and Noncompetitive Ligands of the Organic Cation Transporter 1 (OCT1; SLC22A1).J Med Chem2017
28385543Rosuvastatin Pharmacokinetics in Asian and White Subjects Wild Type for Both OATP1B1 and BCRP Under Control and Inhibited Conditions.J Pharm Sci2017
28495567Transporters Involved in Metformin Pharmacokinetics and Treatment Response.J Pharm Sci2017
27803021Interaction of 2,4-Diaminopyrimidine-Containing Drugs Including Fedratinib and Trimethoprim with Thiamine Transporters.Drug Metab Dispos2017
27378919Pharmacometabolomic Assessment of Metformin in Non-diabetic, African Americans.Front Pharmacol2016
27447836Metabolomic and Genome-wide Association Studies Reveal Potential Endogenous Biomarkers for OATP1B1.Clin Pharmacol Ther2016
25676789Genome-wide association study identifies ABCG2 (BCRP) as an allopurinol transporter and a determinant of drug response.Clin Pharmacol Ther2015
26528626Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3).Mol Pharm2015
25920679Targeted disruption of organic cation transporter 3 attenuates the pharmacologic response to metformin.Mol Pharmacol2015
24961373OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin.Proc Natl Acad Sci U S A2014
24853734Genetic variants in transcription factors are associated with the pharmacokinetics and pharmacodynamics of metformin.Clin Pharmacol Ther2014
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Vanderbilt University Medical Center
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Center for Biomedical Informatics, University of Tennessee Health Science Center
Co-authored papers 1
University of California san francisco
Co-authored papers 1
F. Hoffmann-La Roche Ltd.
Co-authored papers 1
Vanderbilt University Medical Center
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National Institute of Environmental Health Sciences
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