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Author Details

Lon R Cardon
BioMarin Pharmaceutical Inc.
1991
202
89
PMIDPaper TitleJournal TitlePublished Year
33850126Identifying therapeutic drug targets using bidirectional effect genes.Nat Commun2021
33087929Exome sequencing and characterization of 49,960 individuals in the UK Biobank.Nature2020
27984508Characterization of ADME gene variation in 21 populations by exome sequencing.Pharmacogenet Genomics2017
26791069Lipoprotein-Associated Phospholipase A2 Loss-of-Function Variant and Risk of Vascular Diseases in 90,000 Chinese Adults.J Am Coll Cardiol2016
28184040Impact of genetically supported target selection on R&D productivity.Nat Rev Drug Discov2016
27538422Precision medicine, genomics and drug discovery.Hum Mol Genet2016
27301456A phenome-wide association study of a lipoprotein-associated phospholipase A2 loss-of-function variant in 90 000 Chinese adults.Int J Epidemiol2016
27573226Trial watch: Impact of genetically supported target selection on R&D productivity.Nat Rev Drug Discov2016
25411163Identification of a variant in KDR associated with serum VEGFR2 and pharmacodynamics of Pazopanib.Clin Cancer Res2015
26121088The support of human genetic evidence for approved drug indications.Nat Genet2015
24687830Prospective validation of HLA-DRB1*07:01 allele carriage as a predictive risk factor for lapatinib-induced liver injury.J Clin Oncol2014
23903214Novelty in the target landscape of the pharmaceutical industry.Nat Rev Drug Discov2013
24316642Reply to Rational drug repositioning by medical genetics.Nat Biotechnol2013
21606947Sequencing of Lp-PLA2-encoding PLA2G7 gene in 2000 Europeans reveals several rare loss-of-function mutations.Pharmacogenomics J2012
23075016Truncated robust distance for clinical laboratory safety data monitoring and assessment.J Biopharm Stat2012
22491277Use of genome-wide association studies for drug repositioning.Nat Biotechnol2012
22604722An abundance of rare functional variants in 202 drug target genes sequenced in 14,002 people.Science2012
22415848Deep sequencing of the LRRK2 gene in 14,002 individuals reveals evidence of purifying selection and independent origin of the p.Arg1628Pro mutation in Europe.Hum Mutat2012
22403302Deep resequencing unveils genetic architecture of ADIPOQ and identifies a novel low-frequency variant strongly associated with adiponectin variation.Diabetes2012
22008728An 18-kDa translocator protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28.J Cereb Blood Flow Metab2012
21245432HLA-DQA1*02:01 is a major risk factor for lapatinib-induced hepatotoxicity in women with advanced breast cancer.J Clin Oncol2011
21789213The use of genome-wide eQTL associations in lymphoblastoid cell lines to identify novel genetic pathways involved in complex traits.PLoS One2011
21576632Pazopanib efficacy in renal cell carcinoma: evidence for predictive genetic markers in angiogenesis-related and exposure-related genes.J Clin Oncol2011
21293453Basic statistical analysis in genetic case-control studies.Nat Protoc2011
21490708Carriage of the V279F null allele within the gene encoding Lp-PLAâ¿¿ is protective from coronary artery disease in South Korean males.PLoS One2011
21145803Association of the hemochromatosis gene with pazopanib-induced transaminase elevation in renal cell carcinoma.J Hepatol2011
20088020Optimizing the power of genome-wide association studies by using publicly available reference samples to expand the control group.Genet Epidemiol2010
27325954Genome-wide association analysis and replication of coronary artery disease in South Korea suggests a causal variant common to diverse populations.Heart Asia2010
21085122Data quality control in genetic case-control association studies.Nat Protoc2010
20864672Genetic variants influencing circulating lipid levels and risk of coronary artery disease.Arterioscler Thromb Vasc Biol2010
20485427Thousands of chemical starting points for antimalarial lead identification.Nature2010
20389299Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism.Br J Cancer2010
20403135The genetics of NOD-like receptors in Crohn's disease.Tissue Antigens2010
20013941Aspects of observing and claiming allele flips in association studies.Genet Epidemiol2010
18712713Repeat instability in the 27-39 CAG range of the HD gene in the Venezuelan kindreds: Counseling implications.Am J Med Genet B Neuropsychiatr Genet2009
19915574Common variants at five new loci associated with early-onset inflammatory bowel disease.Nat Genet2009
19878600GLIDERS--a web-based search engine for genome-wide linkage disequilibrium between HapMap SNPs.BMC Bioinformatics2009
19812666Finding the missing heritability of complex diseases.Nature2009
19396169A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits.Nat Genet2009
19390530Marker selection for genetic case-control association studies.Nat Protoc2009
19139842Risk prediction of prevalent diabetes in a Swiss population using a weighted genetic score--the CoLaus Study.Diabetologia2009
17505501Genome-wide pharmacogenetic investigation of a hepatic adverse event without clinical signs of immunopathology suggests an underlying immune pathogenesis.Pharmacogenomics J2008
18835879Fine mapping of the MHC Class III region demonstrates association of AIF1 and rheumatoid arthritis.Rheumatology (Oxford)2008
19020537Investigation of the fine structure of European populations with applications to disease association studies.Eur J Hum Genet2008
18940312Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes.Am J Hum Genet2008
18505952Genetic susceptibility to cancer: the role of polymorphisms in candidate genes.JAMA2008
18481795Genomewide linkage scan reveals novel loci modifying age of onset of Huntington's disease in the Venezuelan HD kindreds.Genet Epidemiol2008
18589396Evaluating the effects of imputation on the power, coverage, and cost efficiency of genome-wide SNP platforms.Am J Hum Genet2008
18587394Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.Nat Genet2008
18318908Goldsurfer2 (Gs2): a comprehensive tool for the analysis and visualization of genome wide association studies.BMC Bioinformatics2008
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Collaborators

Gon??alo R Abecasis
Regeneron Pharmaceuticals Inc.
Co-authored papers 24
Andrew P Morris
The University of Manchester
Co-authored papers 23
Panos Deloukas
William Harvey Research Institute, Queen Mary University of London
Co-authored papers 18
Mark I McCarthy
Co-authored papers 13
David M Evans
Medical Research Council Integrative Epidemiology Unit at the University of Bristol
Co-authored papers 12
Sarah E Hunt
European Bioinformatics Institute
Co-authored papers 12
Jeffrey C Barrett
Co-authored papers 12
Geraldine M Clarke
University of Oxford
Co-authored papers 11
Xiayi Ke
Co-authored papers 11
Jonathan Marchini
Regeneron Pharmaceuticals Inc
Co-authored papers 10
Vincent Mooser
McGill University
Co-authored papers 9
Carl A Anderson
Wellcome Sanger Institute
Co-authored papers 9
David R Bentley
Illumina Cambridge Ltd.
Co-authored papers 9
Timothy M Frayling
Co-authored papers 8
Dawn M Waterworth
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Vincent E Mooser
Co-authored papers 7
Mark Lathrop
Victor Philip Dahdaleh Institute of Genomic Medicine at McGill University
Co-authored papers 7
Christopher G Mathew
Co-authored papers 7
Dermot P B McGovern
F. Widjaja Inflammatory Bowel Disease Institute
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Mark Walker
Co-authored papers 7
Andrew T Hattersley
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Graham A Hitman
Co-authored papers 7
Rhian Gwilliam
The Wellcome Trust Sanger Institute
Co-authored papers 7
Pak C Sham
the University of Hong Kong
Co-authored papers 6
Christopher J Groves
Co-authored papers 6
Eleftheria Zeggini
Co-authored papers 6
Kijoung Song
Co-authored papers 6
Peter Donnelly
University of Oxford
Co-authored papers 6
Matthew A Brown
Co-authored papers 6
Robert Lawrence
Co-authored papers 6
Release 1.2