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Author Details

William C Mobley
University of California San Diego
1973
233
79
PMIDPaper TitleJournal TitlePublished Year
36095039Disentangling self from pain: mindfulness meditation-induced pain relief is driven by thalamic-default mode network decoupling.Pain2023
37021132Editorial: Current advances in the study of Down Syndrome: From development to aging.Front Neurosci2023
37449271Modeling Alzheimer's disease related phenotypes in the Ts65Dn mouse: impact of age on Aβ, Tau, pTau, NfL, and behavior.Front Neurosci2023
37042072Retromer Proteins Reduced in Down Syndrome and the Dp16 Model: Impact of APP Dose and Preclinical Studies of a γ-Secretase Modulator.Ann Neurol2023
37428606Therapeutic Potential of PTB Inhibition Through Converting Glial Cells to Neurons in the Brain.Annu Rev Neurosci2023
36370135Reduced synaptic proteins and SNARE complexes in Down syndrome with Alzheimer's disease and the Dp16 mouse Down syndrome model: Impact of APP gene dose.Alzheimers Dement2023
34757693Impact of increased APP gene dose in Down syndrome and the Dp16 mouse model.Alzheimers Dement2022
35532913Safety, Tolerability, and Immunogenicity of the ACI-24 Vaccine in Adults With Down Syndrome: A Phase 1b Randomized Clinical Trial.JAMA Neurol2022
35957650Learning to Practice Compassionate Care: Medical Students Discuss Their Most Memorable Lessons.J Patient Exp2022
34990205Prenatal and Postnatal Pharmacotherapy in Down Syndrome: The Search to Prevent or Ameliorate Neurodevelopmental and Neurodegenerative Disorders.Annu Rev Pharmacol Toxicol2022
32618475Minocycline Topical Foam: A New Drug for the Treatment of Acne.Ann Pharmacother2021
33651103Preclinical validation of a potent γ-secretase modulator for Alzheimer's disease prevention.J Exp Med2021
33924960Cross-Sectional Exploration of Plasma Biomarkers of Alzheimer's Disease in Down Syndrome: Early Data from the Longitudinal Investigation for Enhancing Down Syndrome Research (LIFE-DSR) Study.J Clin Med2021
33729670Specialty clinics for adults with Down syndrome: A clinic survey.Am J Med Genet A2021
33691783Normal levels of KIF5 but reduced KLC1 levels in both Alzheimer disease and Alzheimer disease in Down syndrome: evidence suggesting defects in anterograde transport.Alzheimers Res Ther2021
33660221Specific Susceptibility to COVID-19 in Adults with Down Syndrome.Neuromolecular Med2021
34421499Building the Future Therapies for Down Syndrome: The Third International Conference of the T21 Research Society.Mol Syndromol2021
34276349Mechanistic Analysis of Age-Related Clinical Manifestations in Down Syndrome.Front Aging Neurosci2021
34248930Immune Dysregulation and the Increased Risk of Complications and Mortality Following Respiratory Tract Infections in Adults With Down Syndrome.Front Immunol2021
34268067Opportunities, barriers, and recommendations in down syndrome research.Transl Sci Rare Dis2021
33948879Correction to: Specific Susceptibility to COVID-19 in Adults with Down Syndrome.Neuromolecular Med2021
32975365Targeting increased levels of APP in Down syndrome: Posiphen-mediated reductions in APP and its products reverse endosomal phenotypes in the Ts65Dn mouse model.Alzheimers Dement2021
32544310Further understanding the connection between Alzheimer's disease and Down syndrome.Alzheimers Dement2020
31980301Enabling Technologies for Personalized and Precision Medicine.Trends Biotechnol2020
33288820Detailed evaluation of the upper airway in the Dp(16)1Yey mouse model of Down syndrome.Sci Rep2020
33007551Design and synthesis of novel methoxypyridine-derived gamma-secretase modulators.Bioorg Med Chem2020
32974736Editorial for the special issue neurotrophic factors.Cell Tissue Res2020
32601248Soluble SORLA Enhances Neurite Outgrowth and Regeneration through Activation of the EGF Receptor/ERK Signaling Axis.J Neurosci2020
32936344Local TrkB signaling: themes in development and neural plasticity.Cell Tissue Res2020
32724206Author Correction: Reversing a model of Parkinson's disease with in situ converted nigral neurons.Nature2020
32581380Reversing a model of Parkinson's disease with in situ converted nigral neurons.Nature2020
32281945(H)Elping nerve growth factor: Elp1 inhibits TrkA's phosphatase to maintain retrograde signaling.J Clin Invest2020
31133787Exploring the Pathogenesis of Alzheimer Disease in Basal Forebrain Cholinergic Neurons: Converging Insights From Alternative Hypotheses.Front Neurosci2019
31753140Down syndrome.Handb Clin Neurol2019
31293377Alzheimer Disease Pathogenesis: Insights From Molecular and Cellular Biology Studies of Oligomeric Aβ and Tau Species.Front Neurosci2019
29031834Dysregulation of neurotrophin signaling in the pathogenesis of Alzheimer disease and of Alzheimer disease in Down syndrome.Free Radic Biol Med2018
30120810T-complex protein 1-ring complex enhances retrograde axonal transport by modulating tau phosphorylation.Traffic2018
29609879Trends in Readmission Rates, Hospital Charges, and Mortality for Patients With Chronic Obstructive Pulmonary Disease (COPD) in Florida From 2009 to 2014.Clin Ther2018
29576115Inhibition of RhoA reduces propofol-mediated growth cone collapse, axonal transport impairment, loss of synaptic connectivity, and behavioural deficits.Br J Anaesth2018
29483280Swedish Nerve Growth Factor Mutation (NGF<sup>R100W</sup>) Defines a Role for TrkA and p75<sup>NTR</sup> in Nociception.J Neurosci2018
28587118Nerve Growth Factor and Related Substances: A Brief History and an Introduction to the International NGF Meeting Series.Int J Mol Sci2017
28342823Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome.Neurobiol Dis2017
28416568Pharmacological and Toxicological Properties of the Potent Oral <i>γ</i>-Secretase Modulator BPN-15606.J Pharmacol Exp Ther2017
28946567PET Imaging of Tau Pathology and Relationship to Amyloid, Longitudinal MRI, and Cognitive Change in Down Syndrome: Results from the Down Syndrome Biomarker Initiative (DSBI).J Alzheimers Dis2017
27023444An Anti-β-Amyloid Vaccine for Treating Cognitive Deficits in a Mouse Model of Down Syndrome.PLoS One2016
28642933Dissociation of Down syndrome and Alzheimer's disease effects with imaging.Alzheimers Dement (N Y)2016
27701794GABAergic hyperinnervation of dentate granule cells in the Ts65Dn mouse model of down syndrome: Exploring the role of App.Hippocampus2016
27789459Mouse-based genetic modeling and analysis of Down syndrome.Br Med Bull2016
27601642TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington's disease.Proc Natl Acad Sci U S A2016
27998093Cucurbit[7]uril-Tetramethylrhodamine Conjugate for Direct Sensing and Cellular Imaging.J Am Chem Soc2016
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Collaborators

Co-authored papers 22
Co-authored papers 10
Weill Institute for Neurosciences, University of California San Francisco
Co-authored papers 9
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Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield
Co-authored papers 8
Hoag Memorial Hospital Presbyterian
Co-authored papers 7
National Institute On Aging
Co-authored papers 7
University of Tennessee Health Science Center
Co-authored papers 5
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University of California Irvine
Co-authored papers 5
Co-authored papers 4
Institut Clinique de la Souris (ICS), Universite de Strasbourg, CNRS, INSERM
Co-authored papers 4
University of California san francisco
Co-authored papers 4
Co-authored papers 3
Alzheimer's Therapeutic Research Institute, University of Southern California
Co-authored papers 3
Stanford University School of Medicine
Co-authored papers 3
Co-authored papers 3
Barrow Neurological Institute
Co-authored papers 3
University of California
Co-authored papers 3
Co-authored papers 2
Banner Alzheimer's Institute
Co-authored papers 2
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Johns Hopkins University School of Medicine
Co-authored papers 2
College of Chemistry and Chemical Engineering, Hunan University
Co-authored papers 2
St. Jude Children's Research Hospital
Co-authored papers 2
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New York Presbyterian Hospital, Columbia University Medical Center
Co-authored papers 2