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Author Details

Timothy J McMahon
Duke University Health System
1991
77
26
PMIDPaper TitleJournal TitlePublished Year
36296435Design, Synthesis, and Investigation of Novel Nitric Oxide (NO)-Releasing Aromatic Aldehydes as Drug Candidates for the Treatment of Sickle Cell Disease.Molecules2022
33449849Pannexin 1 channels control the hemodynamic response to hypoxia by regulating O<sub>2</sub>-sensitive extracellular ATP in blood.Am J Physiol Heart Circ Physiol2021
32203007Effects of repleting organic phosphates in banked erythrocytes on plasma metabolites and vasoactive mediators after red cell exchange transfusion in sickle cell disease.Blood Transfus2020
32576698HGT in the human and skin commensal <i>Malassezia</i>: A bacterially derived flavohemoglobin is required for NO resistance and host interaction.Proc Natl Acad Sci U S A2020
31484636Nitric oxide loading reduces sickle red cell adhesion and vaso-occlusion in vivo.Blood Adv2019
29243830Proceedings of the Food and Drug Administration's public workshop on new red blood cell product regulatory science 2016.Transfusion2018
29931051Drebrin regulates angiotensin II-induced aortic remodelling.Cardiovasc Res2018
30576340Red blood cell phenotype fidelity following glycerol cryopreservation optimized for research purposes.PLoS One2018
29025575Biomarkers in Pulmonary Vascular Disease: Gauging Response to Therapy.Am J Cardiol2017
28382373Antagonists of the system L neutral amino acid transporter (LAT) promote endothelial adhesivity of human red blood cells.Thromb Haemost2017
27060546S-Nitrosylated fetal hemoglobin in neonatal human blood.Biochem Biophys Res Commun2016
25611885Treatment-related biomarkers in pulmonary hypertension.Am J Respir Cell Mol Biol2015
26542252Platelets promote pulmonary pull of polys.Blood2015
26098062Renitrosylation of banked human red blood cells improves deformability and reduces adhesivity.Transfusion2015
25766567Liberation of ATP secondary to hemolysis is not mutually exclusive of regulated export.Blood2015
24735194Randomized study of washing 40- to 42-day-stored red blood cells.Transfusion2014
25305182Restoration of intracellular ATP production in banked red blood cells improves inducible ATP export and suppresses RBC-endothelial adhesion.Am J Physiol Heart Circ Physiol2014
23161885Automated measurement of blood flow velocity and direction and hemoglobin oxygen saturation in the rat lung using intravital microscopy.Am J Physiol Lung Cell Mol Physiol2013
23827235Parallel assay of oxygen equilibria of hemoglobin.Anal Biochem2013
23438482Proteomic analysis of the NOS2 interactome in human airway epithelial cells.Nitric Oxide2013
21907348Inhaled nitric oxide therapy increases blood nitrite, nitrate, and s-nitrosohemoglobin concentrations in infants with pulmonary hypertension.J Pediatr2012
22452273Impact of transfusion of autologous 7- versus 42-day-old AS-3 red blood cells on tissue oxygenation and the microcirculation in healthy volunteers.Transfusion2012
22550218The opprobrium of Big Tobacco.Am J Respir Crit Care Med2012
22323364Transpulmonary flux of S-nitrosothiols and pulmonary vasodilation during nitric oxide inhalation: role of transport.Am J Respir Cell Mol Biol2012
20348208Nitric oxide mediates relative airway hyporesponsiveness to lipopolysaccharide in surfactant protein A-deficient mice.Am J Respir Cell Mol Biol2011
21765360Impaired adenosine-5'-triphosphate release from red blood cells promotes their adhesion to endothelial cells: a mechanism of hypoxemia after transfusion.Crit Care Med2011
20423728Transport rather than diffusion-dependent route for nitric oxide gas activity in alveolar epithelium.Free Radic Biol Med2010
18441097Pulmonary alveolar epithelial uptake of S-nitrosothiols is regulated by L-type amino acid transporter.Am J Physiol Lung Cell Mol Physiol2008
17420301Transport and peripheral bioactivities of nitrogen oxides carried by red blood cell hemoglobin: role in oxygen delivery.Physiology (Bethesda)2007
17940021Evolution of adverse changes in stored RBCs.Proc Natl Acad Sci U S A2007
16391304Physician subsidies for tobacco advertising.Am J Respir Crit Care Med2006
16891657Excitation-contraction coupling in airway smooth muscle.J Biol Chem2006
16565424Extrapulmonary effects of inhaled nitric oxide: role of reversible S-nitrosylation of erythrocytic hemoglobin.Proc Am Thorac Soc2006
16126786S-nitrosoglutathione inhibits alpha1-adrenergic receptor-mediated vasoconstriction and ligand binding in pulmonary artery.Am J Physiol Lung Cell Mol Physiol2006
15879309Oxygen regulation of tumor perfusion by S-nitrosohemoglobin reveals a pressor activity of nitric oxide.Circ Res2005
16203976A nitric oxide processing defect of red blood cells created by hypoxia: deficiency of S-nitrosohemoglobin in pulmonary hypertension.Proc Natl Acad Sci U S A2005
16148069A novel inhaled organic nitrate that affects pulmonary vascular tone in a piglet model of hypoxia-induced pulmonary hypertension.Pediatr Res2005
16373824Redox activation of intracellular calcium release channels (ryanodine receptors) in the sustained phase of hypoxia-induced pulmonary vasoconstriction.Chest2005
15824313Hemoglobin conformation couples erythrocyte S-nitrosothiol content to O2 gradients.Proc Natl Acad Sci U S A2005
14980227Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock.Cell2004
12727142S-nitrosylation in health and disease.Trends Mol Med2003
12879896Hemoglobin and nitric oxide.N Engl J Med2003
12814919S-nitrosohemoglobin is distinguished from other nitrosovasodilators by unique oxygen-dependent responses that support an allosteric mechanism of action.Blood2003
11943671Pulmonary vasoconstriction by serotonin is inhibited by S-nitrosoglutathione.Am J Physiol Lung Cell Mol Physiol2002
12042776Nitric oxide in the human respiratory cycle.Nat Med2002
11320213S-nitrosothiol repletion by an inhaled gas regulates pulmonary function.Proc Natl Acad Sci U S A2001
10747928Functional coupling of oxygen binding and vasoactivity in S-nitrosohemoglobin.J Biol Chem2000
9919558Concerted nitric oxide/oxygen delivery by hemoglobin.Methods Enzymol1999
9799212In vivo gene transfer of nitric oxide synthase enhances vasomotor function in carotid arteries from normal and cholesterol-Fed rabbits.Circulation1998
9643794Bronchodilator S-nitrosothiol deficiency in asthmatic respiratory failure.Lancet1998
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Collaborators

Center for Blood Oxygen Transport and Hemostasis, University of Maryland
Co-authored papers 5
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Renaissance School of Medicine at Stony, Brook University
Co-authored papers 3
From the National Institutes of Health
Co-authored papers 2
University of Colorado Anschutz Medical Campus
Co-authored papers 2
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Vitalant Research Institute
Co-authored papers 1
University of Virginia
Co-authored papers 1
0Nationwide Children's Hospital
Co-authored papers 1
Harborview Medical Center
Co-authored papers 1
University of California
Co-authored papers 1
Duke University Medical Center
Co-authored papers 1
Pittsburgh University
Co-authored papers 1
University of Guelph
Co-authored papers 1
Vitalant Research Institute
Co-authored papers 1
The Royal London Hospital, West Hertfordshire Teaching Hospitals NHS Trust
Co-authored papers 1
Center for Genomic and Computational Biology
Co-authored papers 1
Clinical Center, National Institutes of Health
Co-authored papers 1
United States Army Institute of Surgical Research
Co-authored papers 1
Johns Hopkins University
Co-authored papers 1
Dartmouth College, New Hampshire Geisel School of Medicine
Co-authored papers 1
University of California San Diego
Co-authored papers 1
Clinical Sciences
Co-authored papers 1
Clinical Center, National Institutes of Health
Co-authored papers 1
Loma Linda University
Co-authored papers 1
University of Colorado Anschutz Medical Campus
Co-authored papers 1
Naval Medical Research Unit San Antonio
Co-authored papers 1
Center for Biologics Evaluation and Research Food and Drug Administration (FDA)
Co-authored papers 1
Duke University School of Medicine
Co-authored papers 1
University of Alberta
Co-authored papers 1