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Author Details

Jack Taunton
University of California san francisco
1996
102
53
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36638793An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes.Cell2023
37460812Direct mapping of ligandable tyrosines and lysines in cells with chiral sulfonyl fluoride probes.Nat Chem2023
37354015Large library docking for novel SARS-CoV-2 main protease non-covalent and covalent inhibitors.Protein Sci2023
37020024mRNA decoding in human is kinetically and structurally distinct from bacteria.Nature2023
37169961Signal peptide mimicry primes Sec61 for client-selective inhibition.Nat Chem Biol2023
36123449Synthesis and single-molecule imaging reveal stereospecific enhancement of binding kinetics by the antitumour eEF1A antagonist SR-A3.Nat Chem2022
35434798Inhibition of the Sec61 translocon overcomes cytokine-induced glucocorticoid resistance in T-cell acute lymphoblastic leukaemia.Br J Haematol2022
35590003Reversible lysine-targeted probes reveal residence time-based kinase selectivity.Nat Chem Biol2022
36480603IFITM proteins assist cellular uptake of diverse linked chemotypes.Science2022
36264623Didemnin B and ternatin-4 differentially inhibit conformational changes in eEF1A required for aminoacyl-tRNA accommodation into mammalian ribosomes.Elife2022
34251165Identifying the Cellular Target of Cordyheptapeptide A and Synthetic Derivatives.ACS Chem Biol2021
33681312Corrigendum: p90RSK-MAGI1 Module Controls Endothelial Permeability by Post-translational Modifications of MAGI1 and Hippo Pathway.Front Cardiovasc Med2021
32353859A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.Nature2020
32105459Discovery of Lysine-Targeted eIF4E Inhibitors through Covalent Docking.J Am Chem Soc2020
32009391Ligand Conformational Bias Drives Enantioselective Modification of a Surface-Exposed Lysine on Hsp90.J Am Chem Soc2020
33304925p90RSK-MAGI1 Module Controls Endothelial Permeability by Post-translational Modifications of MAGI1 and Hippo Pathway.Front Cardiovasc Med2020
32589729CRISPR-based screens uncover determinants of immunotherapy response in multiple myeloma.Blood Adv2020
30586719Senescent Phenotype Induced by p90RSK-NRF2 Signaling Sensitizes Monocytes and Macrophages to Oxidative Stress in HIV-Positive Individuals.Circulation2019
31045573Endothelial senescence is induced by phosphorylation and nuclear export of telomeric repeat binding factor 2-interacting protein.JCI Insight2019
30944250MAGI1 as a link between endothelial activation and ER stress drives atherosclerosis.JCI Insight2019
30633551Lysine-Targeted Inhibitors and Chemoproteomic Probes.Annu Rev Biochem2019
29622655Repurposing tofacitinib as an anti-myeloma therapeutic to reverse growth-promoting effects of the bone marrow microenvironment.Haematologica2018
29540678Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4.Cell Death Dis2018
28051857Broad-Spectrum Kinase Profiling in Live Cells with Lysine-Targeted Sulfonyl Fluoride Probes.J Am Chem Soc2017
28484265JAK/STAT pathway inhibition overcomes IL7-induced glucocorticoid resistance in a subset of human T-cell acute lymphoblastic leukemias.Leukemia2017
29259099IL-2Rβ abundance differentially tunes IL-2 signaling dynamics in CD4<sup>+</sup> and CD8<sup>+</sup> T cells.Sci Signal2017
29054929Mitogen- and stress-activated protein kinase 1 is required for gonadotropin-releasing hormone-mediated activation of gonadotropin α-subunit expression.J Biol Chem2017
29296813Oncogenic role and therapeutic targeting of ABL-class and JAK-STAT activating kinase alterations in Ph-like ALL.Blood Adv2017
26789921Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection.Immunity2016
27935477Regulation of B cell fate by chronic activity of the IgE B cell receptor.Elife2016
27821549Mycolactone subverts immunity by selectively blocking the Sec61 translocon.J Exp Med2016
27768872Chromatin Kinases Act on Transcription Factors and Histone Tails in Regulation of Inducible Transcription.Mol Cell2016
27863242Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes.Cell2016
27203376Apratoxin Kills Cells by Direct Blockade of the Sec61 Protein Translocation Channel.Cell Chem Biol2016
27477907Engineered Covalent Inactivation of TFIIH-Kinase Reveals an Elongation Checkpoint and Results in Widespread mRNA Stabilization.Mol Cell2016
27018889Essential biphasic role for JAK3 catalytic activity in IL-2 receptor signaling.Nat Chem Biol2016
27056844Phase separation of signaling molecules promotes T cell receptor signal transduction.Science2016
25689261Disturbed flow-activated p90RSK kinase accelerates atherosclerosis by inhibiting SENP2 function.J Clin Invest2015
26485080Corrigendum: The promise and peril of chemical probes.Nat Chem Biol2015
26651998Ternatin and improved synthetic variants kill cancer cells by targeting the elongation factor-1A ternary complex.Elife2015
26554011Allosteric N-WASP activation by an inter-SH3 domain linker in Nck.Proc Natl Acad Sci U S A2015
26006010Prolonged and tunable residence time using reversible covalent kinase inhibitors.Nat Chem Biol2015
25619841Targeting HER3 by interfering with its Sec61-mediated cotranslational insertion into the endoplasmic reticulum.Oncogene2015
25689339Erratum: Covalent docking of large libraries for the discovery of chemical probes.Nat Chem Biol2015
24497544An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate.Elife2014
25344815Covalent docking of large libraries for the discovery of chemical probes.Nat Chem Biol2014
25399643Targeting protein kinases with selective and semipromiscuous covalent inhibitors.Methods Enzymol2014
25153195Design of reversible, cysteine-targeted Michael acceptors guided by kinetic and computational analysis.J Am Chem Soc2014
23243209A crucial role for p90RSK-mediated reduction of ERK5 transcriptional activity in endothelial dysfunction and atherosclerosis.Circulation2013
24085294The prometastatic ribosomal S6 kinase 2-cAMP response element-binding protein (RSK2-CREB) signaling pathway up-regulates the actin-binding protein fascin-1 to promote tumor metastasis.J Biol Chem2013
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Collaborators

Brian K Shoichet
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 6
Alma L Burlingame
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 5
Kevan M Shokat
University of California San Francisco
Co-authored papers 4
John J Irwin
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 4
Stuart L Schreiber
Broad Institute
Co-authored papers 3
Adam R Renslo
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 3
Adolfo Garc??a-Sastre
Icahn School of Medicine at Mount Sinai
Co-authored papers 3
Matthew P Jacobson
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 3
Phillip P Sharp
University of California san francisco
Co-authored papers 3
Wendell A Lim
University of California san francisco
Co-authored papers 2
James S Fraser
University of California san francisco
Co-authored papers 2
Jennifer L Snead
University of New Mexico Health Sciences Center
Co-authored papers 2
Philippe P Roux
IRIC - University of Montreal
Co-authored papers 2
Sagar Lonial
Co-authored papers 2
Charles S Craik
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 2
Arun P Wiita
University of California San Francisco
Co-authored papers 2
Bryan L Roth
UNC Chapel Hill School of Medicine
Co-authored papers 2
Michael G Katze
University of Washington
Co-authored papers 2
Nir London
The Weizmann Institute of Science
Co-authored papers 2
Judd F Hultquist
Northwestern University Feinberg School of Medicine
Co-authored papers 2
Kris M White
Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG)
Co-authored papers 2
Nicole A Wenzell
Quantitative Biosciences Institute (QBI), University of California San Francisco
Co-authored papers 2
Keri Schadler
The University of Texas MD Anderson Cancer Center
Co-authored papers 2
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 2
Mark von Zastrow
University of California san francisco
Co-authored papers 2
Davide Ruggero
University of California San Francisco
Co-authored papers 2
Arthur Weiss
University of California san francisco
Co-authored papers 2
Dandan Sun
Co-authored papers 2
Steven H Lin
University of Texas MD Anderson Cancer Center
Co-authored papers 2
John P Cooke
Co-authored papers 2
Release 1.2