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Author Details

Michael A Rogawski
University of California davis
1974
247
75
PMIDPaper TitleJournal TitlePublished Year
36413125A randomized, open-label, two-treatment crossover study to evaluate the effect of food on the pharmacokinetics of diazepam nasal spray in healthy adults.Epilepsia2023
36919379Tolerability and pharmacokinetics of intravenous allopregnanolone with and without midazolam pretreatment in two healthy dogs.Epilepsia Open2023
34862270Intravenous and Intramuscular Allopregnanolone for Early Treatment of Status Epilepticus: Pharmacokinetics, Pharmacodynamics, and Safety in Dogs.J Pharmacol Exp Ther2022
33405197Intranasal Allopregnanolone Confers Rapid Seizure Protection: Evidence for Direct Nose-to-Brain Delivery.Neurotherapeutics2021
33914090Perampanel, a potent AMPA receptor antagonist, protects against tetramethylenedisulfotetramine-induced seizures and lethality in mice: comparison with diazepam.Arch Toxicol2021
34478772Strain differences in the extent of brain injury in mice after tetramethylenedisulfotetramine-induced status epilepticus.Neurotoxicology2021
34008857Cortical excitability threshold can be increased by the AMPA blocker Perampanel in amyotrophic lateral sclerosis.Muscle Nerve2021
30905768Persistent behavior deficits, neuroinflammation, and oxidative stress in a rat model of acute organophosphate intoxication.Neurobiol Dis2020
31965829Epilepsy Benchmarks Area III: Improved Treatment Options for Controlling Seizures and Epilepsy-Related Conditions Without Side Effects.Epilepsy Curr2020
33344752Safety, tolerability, and pharmacokinetics of allopregnanolone as a regenerative therapeutic for Alzheimer's disease: A single and multiple ascending dose phase 1b/2a clinical trial.Alzheimers Dement (N Y)2020
32915470Allopregnanolone and perampanel as adjuncts to midazolam for treating diisopropylfluorophosphate-induced status epilepticus in rats.Ann N Y Acad Sci2020
32120063Mechanisms of action of currently used antiseizure drugs.Neuropharmacology2020
32303805The chemical convulsant diisopropylfluorophosphate (DFP) causes persistent neuropathology in adult male rats independent of seizure activity.Arch Toxicol2020
31526646Reduced efficacy and risk of seizure aggravation when cannabidiol is used without clobazam.Epilepsy Behav2020
30187385Allopregnanolone Treatment Improves Plasma Metabolomic Profile Associated with GABA Metabolism in Fragile X-Associated Tremor/Ataxia Syndrome: a Pilot Study.Mol Neurobiol2019
31699662Diazepam buccal film for the treatment of acute seizures.Epilepsy Behav2019
31801886Blood-brain barrier dysfunction in aging induces hyperactivation of TGFβ signaling and chronic yet reversible neural dysfunction.Sci Transl Med2019
28927958Defective GABAergic neurotransmission in the nucleus tractus solitarius in Mecp2-null mice, a model of Rett syndrome.Neurobiol Dis2018
29682729Determination of minimal steady-state plasma level of diazepam causing seizure threshold elevation in rats.Epilepsia2018
29453777Intramuscular allopregnanolone and ganaxolone in a mouse model of treatment-resistant status epilepticus.Epilepsia2018
29247482Commonalities in epileptogenic processes from different acute brain insults: Do they translate?Epilepsia2018
27986596Effects of the synthetic neurosteroid ganaxolone on seizure activity and behavioral deficits in an Angelman syndrome mouse model.Neuropharmacology2017
28416442Allopregnanolone decreases interictal spiking and fast ripples in an animal model of mesial temporal lobe epilepsy.Neuropharmacology2017
28485718Transcriptional profile of hippocampal dentate granule cells in four rat epilepsy models.Sci Data2017
28428226Rapid Throughput Analysis of GABA<sub>A</sub> Receptor Subtype Modulators and Blockers Using DiSBAC<sub>1</sub>(3) Membrane Potential Red Dye.Mol Pharmacol2017
28707277Open-Label Allopregnanolone Treatment of Men with Fragile X-Associated Tremor/Ataxia Syndrome.Neurotherapeutics2017
28589168First-in-man allopregnanolone use in super-refractory status epilepticus.Ann Clin Transl Neurol2017
26801895Mechanisms of Action of Antiseizure Drugs and the Ketogenic Diet.Cold Spring Harb Perspect Med2016
26525567Evaluation of the neuroactive steroid ganaxolone on social and repetitive behaviors in the BTBR mouse model of autism.Psychopharmacology (Berl)2016
27768878A New SV2A Ligand for Epilepsy.Cell2016
273304522014 Epilepsy Benchmarks Area III: Improve Treatment Options for Controlling Seizures and Epilepsy-Related Conditions Without Side Effects.Epilepsy Curr2016
27467073Models to identify treatments for the acute and persistent effects of seizure-inducing chemical threat agents.Ann N Y Acad Sci2016
26912516A fatty acid in the MCT ketogenic diet for epilepsy treatment blocks AMPA receptors.Brain2016
25256961The riluzole derivative 2-amino-6-trifluoromethylthio-benzothiazole (SKA-19), a mixed KCa2 activator and NaV blocker, is a potent novel anticonvulsant.Neurotherapeutics2015
26378885Contrasting actions of a convulsant barbiturate and its anticonvulsant enantiomer on the α1 β3 γ2L GABAA receptor account for their in vivo effects.J Physiol2015
26581972Is a separate monotherapy indication warranted for antiepileptic drugs?Lancet Neurol2015
26039057Allopregnanolone preclinical acute pharmacokinetic and pharmacodynamic studies to predict tolerability and efficacy for Alzheimer's disease.PLoS One2015
25882826Combined treatment with diazepam and allopregnanolone reverses tetramethylenedisulfotetramine (TETS)-induced calcium dysregulation in cultured neurons and protects TETS-intoxicated mice against lethal seizures.Neuropharmacology2015
25616473Current understanding of the mechanism of action of the antiepileptic drug lacosamide.Epilepsy Res2015
24671870The potential of antiseizure drugs and agents that act on novel molecular targets as antiepileptogenic treatments.Neurotherapeutics2014
25448683Post-exposure administration of diazepam combined with soluble epoxide hydrolase inhibition stops seizures and modulates neuroinflammation in a murine model of acute TETS intoxication.Toxicol Appl Pharmacol2014
25229608Perampanel inhibition of AMPA receptor currents in cultured hippocampal neurons.PLoS One2014
25363147Pediatric super-refractory status epilepticus treated with allopregnanolone.Ann Neurol2014
24760837Role of GluK1 kainate receptors in seizures, epileptic discharges, and epileptogenesis.J Neurosci2014
24705905Anticonvulsant potencies of the enantiomers of the neurosteroids androsterone and etiocholanolone exceed those of the natural forms.Psychopharmacology (Berl)2014
23298414Glia and epilepsy: excitability and inflammation.Trends Neurosci2013
24349022Epoxy fatty acids and inhibition of the soluble epoxide hydrolase selectively modulate GABA mediated neurotransmission to delay onset of seizures.PLoS One2013
23909851Issues related to development of new antiseizure treatments.Epilepsia2013
23909850Epilepsy therapy development: technical and methodologic issues in studies with animal models.Epilepsia2013
23906638Proconvulsant actions of intrahippocampal botulinum neurotoxin B in the rat.Neuroscience2013
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Collaborators

University of California davis
Co-authored papers 10
University of California davis
Co-authored papers 4
Royal Victoria Hospital
Co-authored papers 2
Oregon National Primate Research Center, Oregon Health and Science University.
Co-authored papers 2
University of California san francisco
Co-authored papers 2
Boston Children's Hospital
Co-authored papers 2
Center for Coregulator Research, Baylor College of Medicine
Co-authored papers 2
Johns Hopkins University School of Medicine
Co-authored papers 2
Institute of Functional Genomics, University of Montpellier, CNRS, INSERM
Co-authored papers 2
National Institutes of Health
Co-authored papers 1
David Geffen School of Medicine at university of california los angeles
Co-authored papers 1
University of Texas Southwestern Medical Center at Dallas
Co-authored papers 1
University of South Florida
Co-authored papers 1
Co-authored papers 1
University of Colorado Health Science Center
Co-authored papers 1
Harvard Medical School
Co-authored papers 1
National Institutes of Health
Co-authored papers 1
Co-authored papers 1
Massachusetts General Hospital, Harvard Medical School
Co-authored papers 1
Keck School of Medicine (EJ, University of Southern California
Co-authored papers 1
University of Minnesota Twin Cities
Co-authored papers 1
Seattle Children's Hospital, University of Washington
Co-authored papers 1
Northwestern University Feinberg School of Medicine
Co-authored papers 1
Howard Hughes Medical Institute, The University of California berkeley
Co-authored papers 1
Cincinnati Children's Hospital Medical Center
Co-authored papers 1
Keck School of Medicine of USC
Co-authored papers 1
Cincinnati Children's Hospital Medical Center
Co-authored papers 1
Beth Israel Deaconess Medical Center, Division of Neurocritical Care and Emergency Neurology, Division of Clinical Neurophysiology, Massachusetts General Hospital, Boston, MA, Harvard Medical School, Massachusetts General Hospital, Massachusetts General Hospital Fellowship in Epilepsy and Clinical Neurophysiology, Massachusetts General Hospital, Brigham and Women's Hospital, Harvard Medical School Fellowship Training Program in Neurocritical Care, Massachusetts General Hospital, Brigham and Women's Hospital, Harvard Medical School Partners Neurology Residency Training Program, Yale College
Co-authored papers 1
Co-authored papers 1
University of North Carolina School of Medicine
Co-authored papers 1