Author details

Full Name

Richard S Paules

Affiliation

ORCID

Career Start Year

1985

Papers

125

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
33140634	The Tox21 10K Compound Library: Collaborative Chemistry Advancing Toxicology.	Chem Res Toxicol	2021
33088175	Utility of Extrapolating Human S1500+ Genes to the Whole Transcriptome: Tunicamycin Case Study.	Bioinform Biol Insights	2020
32344290	KRAS-retroviral fusion transcripts and gene amplification in arsenic-transformed, human prostate CAsE-PE cancer cells.	Toxicol Appl Pharmacol	2020
31757180	DNA damage responses in murine Pre-B cells with genetic deficiencies in damage response genes.	Cell Cycle	2020
32492150	Evaluation of 5-day In Vivo Rat Liver and Kidney With High-throughput Transcriptomics for Estimating Benchmark Doses of Apical Outcomes.	Toxicol Sci	2020
32655620	Comparison of Normalization Methods for Analysis of TempO-Seq Targeted RNA Sequencing Data.	Front Genet	2020
30850835	The Power of Resolution: Contextualized Understanding of Biological Responses to Liver Injury Chemicals Using High-throughput Transcriptomics and Benchmark Concentration Modeling.	Toxicol Sci	2019
30496580	Screening for Developmental Neurotoxicity at the National Toxicology Program: The Future Is Here.	Toxicol Sci	2019
30329029	BMDExpress 2: enhanced transcriptomic dose-response analysis workflow.	Bioinformatics	2019
30521027	Detection and Prioritization of Developmentally Neurotoxic and/or Neurotoxic Compounds Using Zebrafish.	Toxicol Sci	2019
31188086	Development of a Zebrafish S1500+ Sentinel Gene Set for High-Throughput Transcriptomics.		2019
29462216	A hybrid gene selection approach to create the S1500+ targeted gene sets for use in high-throughput transcriptomics.	PLoS One	2018
30312655	Toxicity profiling of flame retardants in zebrafish embryos using a battery of assays for developmental toxicity, neurotoxicity, cardiotoxicity and hepatotoxicity toward human relevance.	Neurotoxicol Teratol	2018
30059008	Comprehensive Analyses and Prioritization of Tox21 10K Chemicals Affecting Mitochondrial Function by in-Depth Mechanistic Studies.	Environ Health Perspect	2018
30420870	A Comparison of the TempO-Seq S1500+ Platform to RNA-Seq and Microarray Using Rat Liver Mode of Action Samples.	Front Genet	2018
29529324	The US Federal Tox21 Program: A strategic and operational plan for continued leadership.	Altex	2018
27829164	Molecular effects of 1-naphthyl-methylcarbamate and solar radiation exposures on human melanocytes.	Toxicol In Vitro	2017
28686730	Correction: Real-time cell toxicity profiling of Tox21 10K compounds reveals cytotoxicity dependent toxicity pathway linkage.	PLoS One	2017
28633424	From the Cover: Three-Dimensional (3D) HepaRG Spheroid Model With Physiologically Relevant Xenobiotic Metabolism Competence and Hepatocyte Functionality for Liver Toxicity Screening.	Toxicological Sciences	2017
28531190	Real-time cell toxicity profiling of Tox21 10K compounds reveals cytotoxicity dependent toxicity pathway linkage.	PLoS One	2017
28478275	Identifying environmental chemicals as agonists of the androgen receptor by using a quantitative high-throughput screening platform.	Toxicology	2017
28362262	A type I IFN-dependent DNA damage response regulates the genetic program and inflammasome activation in macrophages.	Elife	2017
29077947	Three-Dimensional (3D) HepaRG Spheroid Model With Physiologically Relevant Xenobiotic Metabolism Competence and Hepatocyte Functionality for Liver Toxicity Screening.	Toxicological Sciences	2017
26927286	Blood gene expression profiling of an early acetaminophen response.	Pharmacogenomics J	2017
28055944	Comment on "On the Utility of ToxCastâ¿¢ and ToxPi as Methods for Identifying New Obesogens".	Environmental Health Perspectives	2017
26690555	Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen.	Clin Pharmacol Ther	2016
27122658	Intersection of toxicogenomics and high throughput screening in the Tox21 program: an NIEHS perspective.	Int J Biotechnol	2015
25150839	The concordance between RNA-seq and microarray data depends on chemical treatment and transcript abundance.	Nat Biotechnol	2014
25483091	Depletion of ATR selectively sensitizes ATM-deficient human mammary epithelial cells to ionizing radiation and DNA-damaging agents.	Cell Cycle	2014
23496831	DNA damage activates a complex transcriptional response in murine lymphocytes that includes both physiological and cancer-predisposition programs.	BMC Genomics	2013
23943852	Gene expression signatures but not cell cycle checkpoint functions distinguish AT carriers from normal individuals.	Physiological Genomics	2013
23741392	Genome-wide small RNA sequencing and gene expression analysis reveals a microRNA profile of cancer susceptibility in ATM-deficient human mammary epithelial cells.	PLoS ONE	2013
23462183	Dissecting cellular responses to irradiation via targeted disruptions of the ATM-CHK1-PP2A circuit.	Cell Cycle	2013
23454897	A prognostic signature of G(2) checkpoint function in melanoma cell lines.	Cell Cycle	2013
22859947	Perturbation of microRNAs in rat heart during chronic doxorubicin treatment.	PLoS One	2012
21865292	Genomic-derived markers for early detection of calcineurin inhibitor immunosuppressant-mediated nephrotoxicity.	Toxicological Sciences	2011
22997859	Platforms for biomarker analysis using high-throughput approaches in genomics, transcriptomics, proteomics, metabolomics, and bioinformatics.	IARC scientific publications	2011
21147607	Moving forward in human cancer risk assessment.	Environ Health Perspect	2011
21521520	Gene expression profiles from discordant monozygotic twins suggest that molecular pathways are shared among multiple systemic autoimmune diseases.		2011
19918972	Acetaminophen dosing of humans results in blood transcriptome and metabolome changes consistent with impaired oxidative phosphorylation.	Hepatology	2010
20676074	The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models.	Nat Biotechnol	2010
20676066	Genomic indicators in the blood predict drug-induced liver injury.	Pharmacogenomics J	2010
20676064	Consistency of predictive signature genes and classifiers generated using different microarray platforms.	Pharmacogenomics J	2010
20350139	Use of transcriptomics in understanding mechanisms of drug-induced toxicity.	Pharmacogenomics	2010
20308323	Human AlkB homolog ABH8 Is a tRNA methyltransferase required for wobble uridine modification and DNA damage survival.	Mol Cell Biol	2010
20372057	Revised genetic requirements for the decatenation G2 checkpoint: the role of ATM.	Cell Cycle	2010
19008212	Parallelogram approach using rat-human in vitro and rat in vivo toxicogenomics predicts acetaminophen-induced hepatotoxicity in humans.	Toxicol Sci	2009
18172300	DNA protein kinase-dependent G2 checkpoint revealed following knockdown of ataxia-telangiectasia mutated in human mammary epithelial cells.	Cancer Research	2008
17962311	CEBS--Chemical Effects in Biological Systems: a public data repository integrating study design and toxicity data with microarray and proteomics data.	Nucleic Acids Res	2008
18570634	Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype.	Genome Biol	2008