Skip to Main Content

Author Details

Nancy A Speck
Perelman School of Medicine, University of Pennsylvania
1981
160
65
PMIDPaper TitleJournal TitlePublished Year
36741355Hematopoietic Cell Autonomous Disruption of Hematopoiesis in a Germline Loss-of-function Mouse Model of RUNX1-FPD.Hemasphere2023
37536952RUNX1 is required in granulocyte-monocyte progenitors to attenuate inflammatory cytokine production by neutrophils.Genes Dev2023
36747636RUNX1 is required in granulocyte-monocyte progenitors to attenuate inflammatory cytokine production by neutrophils.bioRxiv2023
35139279A Pernicious Cycle Affecting Premalignant Stem Cells.N Engl J Med2022
36473461Mouse placenta fetal macrophages arise from endothelial cells outside the placenta.Dev Cell2022
35043940MyD88-dependent TLR signaling oppositely regulates hematopoietic progenitor and stem cell formation in the embryo.Development2022
35245372Endothelial MEKK3-KLF2/4 signaling integrates inflammatory and hemodynamic signals during definitive hematopoiesis.Blood2022
33974912Intrinsically disordered Meningioma-1 stabilizes the BAF complex to cause AML.Mol Cell2021
33569577RUNX-1 haploinsufficiency causes a marked deficiency of megakaryocyte-biased hematopoietic progenitor cells.Blood2021
33636129In vivo CD8<sup>+</sup> T cell CRISPR screening reveals control by Fli1 in infection and cancer.Cell2021
34675061Efficient hemogenic endothelial cell specification by RUNX1 is dependent on baseline chromatin accessibility of RUNX1-regulated TGFβ target genes.Genes Dev2021
32398861Forks in the road to the first hematopoietic stem cells.Cell Res2020
32392346Developmental trajectory of prehematopoietic stem cell formation from endothelium.Blood2020
32499402Transcriptional regulatory network controlling the ontogeny of hematopoietic stem cells.Genes Dev2020
32208490Runx1 negatively regulates inflammatory cytokine production by neutrophils in response to Toll-like receptor signaling.Blood Adv2020
31216456Macrophages Fertilize the Soil to Promote Hematopoietic Cell Growth.Immunity2019
31851943Spatial Genome Re-organization between Fetal and Adult Hematopoietic Stem Cells.Cell Rep2019
31648317ClinGen Myeloid Malignancy Variant Curation Expert Panel recommendations for germline RUNX1 variants.Blood Adv2019
29249175A tool compound targeting the core binding factor Runt domain to disrupt binding to CBFβ in leukemic cells.Leuk Lymphoma2018
30199018A Western Blotting Protocol for Small Numbers of Hematopoietic Stem Cells.J Vis Exp2018
30391350RUNX1 and the endothelial origin of blood.Exp Hematol2018
29361566Runx1 is sufficient for blood cell formation from non-hemogenic endothelial cells in vivo only during early embryogenesis.Development2018
29282253Maturation of hematopoietic stem cells from prehematopoietic stem cells is accompanied by up-regulation of PD-L1.J Exp Med2018
28550162Rb family proteins enforce the homeostasis of quiescent hematopoietic stem cells by repressing Socs3 expression.J Exp Med2017
28299650The Role of Runx1 in Embryonic Blood Cell Formation.Adv Exp Med Biol2017
29326930<i>RUNX1</i> Mutations in Inherited and Sporadic Leukemia.Front Cell Dev Biol2017
29296814Twist1 regulates embryonic hematopoietic differentiation through binding to <i>Myb</i> and <i>Gata2</i> promoter regions.Blood Adv2017
29018080<i>Chd7</i> deficiency delays leukemogenesis in mice induced by <i>Cbfb-MYH11</i>.Blood2017
28514438Conversion of adult endothelium to immunocompetent haematopoietic stem cells.Nature2017
28588017CD27 marks murine embryonic hematopoietic stem cells and type II prehematopoietic stem cells.Blood2017
27105579Extravascular endothelial and hematopoietic islands form through multiple pathways in midgestation mouse embryos.Dev Biol2016
27588740Stress Can Be a Good Thing for Blood Formation.Cell Stem Cell2016
27389484Insights into blood cell formation from hemogenic endothelium in lesser-known anatomic sites.Dev Dyn2016
27137656Taking the Leap: Runx1 in the Formation of Blood from Endothelium.Curr Top Dev Biol2016
25594182Hematopoietic stem cell arrival triggers dynamic remodeling of the perivascular niche.Cell2015
26460546Loss of neurofibromin Ras-GAP activity enhances the formation of cardiac blood islands in murine embryos.Elife2015
26097038Articular cartilage endurance and resistance to osteoarthritic changes require transcription factor Erg.Arthritis Rheumatol2015
26165925Runx1 Deficiency Decreases Ribosome Biogenesis and Confers Stress Resistance to Hematopoietic Stem and Progenitor Cells.Cell Stem Cell2015
25915127Human definitive haemogenic endothelium and arterial vascular endothelium represent distinct lineages.Nat Cell Biol2015
25926412The Antiatherogenic Effect of Fish Oil in Male Mice Is Associated with a Diminished Release of Endothelial ADAM17 and ADAM10 Substrates.J Nutr2015
25605720The cytoplasmic domain of a disintegrin and metalloproteinase 10 (ADAM10) regulates its constitutive activity but is dispensable for stimulated ADAM10-dependent shedding.J Biol Chem2015
24141110HIF1α is a regulator of hematopoietic progenitor and stem cell development in hypoxic sites of the mouse embryo.Stem Cell Res2014
25395663Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production.Genes Dev2014
24637115The Notch1 transcriptional activation domain is required for development and reveals a novel role for Notch1 signaling in fetal hematopoietic stem cells.Genes Dev2014
24631489Biochanin A and prunetin improve epithelial barrier function in intestinal CaCo-2 cells via downregulation of ERK, NF-κB, and tyrosine phosphorylation.Free Radic Biol Med2014
24677539Runx1 and Cbfβ regulate the development of Flt3+ dendritic cell progenitors and restrict myeloproliferative disorder.Blood2014
23537631Endothelio-mesenchymal interaction controls runx1 expression and modulates the notch pathway to initiate aortic hematopoiesis.Dev Cell2013
24297996Gata2 is required for HSC generation and survival.J Exp Med2013
23924635Distinct temporal requirements for Runx1 in hematopoietic progenitors and stem cells.Development2013
23604320The expression of Sox17 identifies and regulates haemogenic endothelium.Nat Cell Biol2013
  • 1 - 50 of 160

Recommended Authors

Marc A Kerenyi
Boston Children's Hospital, Harvard Medical School
Career Start Year 2006
Number of shared co-authors 3
Sasan Zandi
University of Toronto
Career Start Year 2006
Number of shared co-authors 1
Christopher Y Park
NYU Robert I. Grossman School of Medicine
Career Start Year 2006
Number of shared co-authors 1
Fumio Nakahara
Graduate School of Medicine, The University of Tokyo
Career Start Year 2004
Number of shared co-authors 1
Mathieu Tremblay
Universite de Montreal, Institute for Research in Immunology and Cancer
Career Start Year 2003
Number of shared co-authors 1
Robert M??nsson
Karolinska Institutet
Career Start Year 2003
Number of shared co-authors 2
Sergei Doulatov
University of Washington
Career Start Year 2002
Number of shared co-authors 3
Robert S Welner
University of Alabama at Birmingham
Career Start Year 2002
Number of shared co-authors 2
Devorah C Goldman
Oregon Health & Science University
Career Start Year 2000
Number of shared co-authors 2
Roy Drissen
MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital
Career Start Year 2000
Number of shared co-authors 1
Jalila Chagraoui
Institute for Research in Immunology and Cancer, University of Montreal
Career Start Year 2000
Number of shared co-authors 1
Heather M Rooke
Broad Institute of Harvard and MIT
Career Start Year 1999
Number of shared co-authors 2
Tomokatsu Ikawa
Tokyo University of Science
Career Start Year 1999
Number of shared co-authors 1
Stephanie Halene
Smilow Cancer Center, Yale University School of Medicine
Career Start Year 1997
Number of shared co-authors 0
Frank Rosenbauer
University Munster
Career Start Year 1996
Number of shared co-authors 4
Mikael Sigvardsson
Lund University, Linkoping University. .
Career Start Year 1993
Number of shared co-authors 0
Claus Nerlov
MRC Weatherall Institute of Molecular Medicine, University of Oxford
Career Start Year 1990
Number of shared co-authors 4
Geoffrey Neale
St. Jude Children's Research Hospital
Career Start Year 1989
Number of shared co-authors 3
Jana Krosl
The Leucegene Project at Institute for Research in Immunology and Cancer.
Career Start Year 1989
Number of shared co-authors 0
Guy Sauvageau
Universite de Montreal
Career Start Year 1988
Number of shared co-authors 2
Eric E Bouhassira
Albert Einstein College of Medicine
Career Start Year 1987
Number of shared co-authors 0
Haruhiko Koseki
RIKEN Research Center for Allergy and Immunology
Career Start Year 1986
Number of shared co-authors 4
Tarik M??r??y
Institut de recherches cliniques de Montreal
Career Start Year 1985
Number of shared co-authors 3
Toshio Kitamura
The University of Tokyo.
Career Start Year 1984
Number of shared co-authors 2
Timothy J Ley
Washington University School of Medicine
Career Start Year 1982
Number of shared co-authors 4
Daniel C Link
Washington University School of Medicine
Career Start Year 1982
Number of shared co-authors 3
Cornelis Murre
University of California
Career Start Year 1982
Number of shared co-authors 1
George Q Daley
Boston Children's Hospital, Harvard Medical School
Career Start Year 1982
Number of shared co-authors 1
Trang Hoang
Department of Biomedical Science and Center for Bio-Nanomaterials, Daegu University
Career Start Year 1981
Number of shared co-authors 3
Alex Look
Dana-Farber Cancer Institute
Career Start Year 1975
Number of shared co-authors 12

Collaborators

Kai Tan
University of Pennsylvania
Co-authored papers 14
Francis S Collins
University of Michigan ann arbor
Co-authored papers 7
Daisuke Sugiyama
Translational Research Center, Hiroshima University
Co-authored papers 4
Deborah L French
Co-authored papers 3
Gerald Wertheim
Co-authored papers 3
Gary S Stein
University of Vermont
Co-authored papers 3
Erica A Golemis
Co-authored papers 2
Daniel G Tenen
Harvard Stem Cell Institute, Harvard Medical School
Co-authored papers 2
Hicham Drissi
Co-authored papers 2
Cisca Wijmenga
Co-authored papers 2
Michael J Owen
Co-authored papers 2
Jane B Lian
University of Vermont
Co-authored papers 2
Dong-Er Zhang
Moores Cancer Center, University of California San Diego
Co-authored papers 2
Andre J van Wijnen
Co-authored papers 2
Chimene Kesserwan
National Institutes of Health
Co-authored papers 1
James Palis
Co-authored papers 1
Maksymilian Chruszcz
University of South Carolina, Michigan State University
Co-authored papers 1
Shelley L Berger
Penn Epigenetics Institute, Perelman School of Medicine
Co-authored papers 1
Siob??n B Keel
University of Washington School of Medicine
Co-authored papers 1
David Wu
University of Washington
Co-authored papers 1
Arun Padmanabhan
Gladstone Institutes San Francisco
Co-authored papers 1
Lucy A Godley
The University of Chicago
Co-authored papers 1
Christopher C Porter
Emory University School of Medicine
Co-authored papers 1
Sylvie Le Gall
Co-authored papers 1
Yuan He
Co-authored papers 1
Anupriya Agarwal
Knight Cancer Institute, Oregon Health & Science University
Co-authored papers 1
Michael Chicka
Co-authored papers 1
Mark J Routbort
University of Texas MD Anderson Cancer Center
Co-authored papers 1
Katheleen J Gardiner
Co-authored papers 1
Shannon K McWeeney
Oregon Health & Science University, University of California Berkeley
Co-authored papers 1
Release 1.2