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Author Details
Full Name
Michael C Thompson
Affiliation
University of California
ORCID
Career Start Year
2011
Papers
28
H Index
15
Expertise
CM4AI Collaborator
Nevan J Krogan (CM4AI)
PMID
Paper Title
Journal Title
Published Year
37398339
Structural characterization of ligand binding and pH-specific enzymatic activity of mouse Acidic Mammalian Chitinase.
bioRxiv
2024
37723259
Mapping protein dynamics at high spatial resolution with temperature-jump X-ray crystallography.
Nat Chem
2023
37748829
Combining temperature perturbations with X-ray crystallography to study dynamic macromolecules: A thorough discussion of experimental methods.
Methods Enzymol
2023
37645800
Changes in an Enzyme Ensemble During Catalysis Observed by High Resolution XFEL Crystallography.
bioRxiv
2023
35169801
The mechanisms of catalysis and ligand binding for the SARS-CoV-2 NSP3 macrodomain from neutron and X-ray diffraction at room temperature.
bioRxiv
2022
35622909
The mechanisms of catalysis and ligand binding for the SARS-CoV-2 NSP3 macrodomain from neutron and x-ray diffraction at room temperature.
Sci Adv
2022
35254891
Accurate positioning of functional residues with robotics-inspired computational protein design.
Proc Natl Acad Sci U S A
2022
33853786
Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking.
Sci Adv
2021
32148858
Comparing serial X-ray crystallography and microcrystal electron diffraction (MicroED) as methods for routine structure determination from small macromolecular crystals.
IUCrJ
2020
33154106
An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike.
Science
2020
32968058
Ensemble-based enzyme design can recapitulate the effects of laboratory directed evolution in silico.
Nat Commun
2020
32855341
Expanding the space of protein geometries by computational design of de novo fold families.
Science
2020
32676184
Advances in methods for atomic resolution macromolecular structure determination.
F1000Res
2020
32504875
BATMAN: Fast and Accurate Integration of Single-Cell RNA-Seq Datasets via Minimum-Weight Matching.
iScience
2020
31527847
Temperature-jump solution X-ray scattering reveals distinct motions in a dynamic enzyme.
Nat Chem
2019
31754004
Computational design of a modular protein sense-response system.
Science
2019
31801874
Mix-and-inject XFEL crystallography reveals gated conformational dynamics during enzyme catalysis.
Proc Natl Acad Sci U S A
2019
29717712
Microfocus diffraction from different regions of a protein crystal: structural variations and unit-cell polymorphism.
Acta Crystallogr D Struct Biol
2018
28573574
Identifying and Overcoming Crystal Pathologies: Disorder and Twinning.
Methods Mol Biol
2017
28416112
Flexibility and Design: Conformational Heterogeneity along the Evolutionary Trajectory of a Redesigned Ubiquitin.
Structure
2017
28759216
Allosteric Inhibitors, Crystallography, and Comparative Analysis Reveal Network of Coordinated Movement across Human Herpesvirus Proteases.
J Am Chem Soc
2017
26988700
Structure of a novel 13 nm dodecahedral nanocage assembled from a redesigned bacterial microcompartment shell protein.
Chem Commun (Camb)
2016
25752492
An allosteric model for control of pore opening by substrate binding in the EutL microcompartment shell protein.
Protein Sci
2015
26422513
Mapping the conformational landscape of a dynamic enzyme by multitemperature and XFEL crystallography.
Elife
2015
24419393
A challenging interpretation of a hexagonally layered protein structure.
Acta Crystallogr D Biol Crystallogr
2014
25484204
Structure of a bacterial microcompartment shell protein bound to a cobalamin cofactor.
Acta Crystallogr F Struct Biol Commun
2014
25102080
Identification of a unique Fe-S cluster binding site in a glycyl-radical type microcompartment shell protein.
J Mol Biol
2014
21315581
The protein shells of bacterial microcompartment organelles.
Curr Opin Struct Biol
2011
1 - 28 of 28
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3
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Co-authored papers
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Co-authored papers
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University of California San Francisco
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2
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UCSF Helen Diller Family Comprehensive Cancer Center
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2
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Department of Pharmaceutical Chemistry, University of California-San Francisco
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Ishan Deshpande
Department of Pharmaceutical Chemistry, University of California san francisco
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Gregory E Merz
University of California san francisco
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Co-authored papers
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California Institute of Technology
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Tristan W Owens
University of California san francisco
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