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Author Details

Benjamin P Kleinstiver
Center for Genomic Medicine, Massachusetts General Hospital
2007
65
23
Emma Lundberg (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
38057426Optimization of base editors for the functional correction of SMN2 as a treatment for spinal muscular atrophy.Nat Biomed Eng2024
36049184Recent Advances in Double-Strand Break-Free Kilobase-Scale Genome Editing Technologies.Biochemistry2023
37794046PAM-flexible genome editing with an engineered chimeric Cas9.Nat Commun2023
37745481Click editing enables programmable genome writing using DNA polymerases and HUH endonucleases.bioRxiv2023
37582836Treatment of monogenic and digenic dominant genetic hearing loss by CRISPR-Cas9 ribonucleoprotein delivery in vivo.Nat Commun2023
37547003<i>PMS1</i> as a target for splice modulation to prevent somatic CAG repeat expansion in Huntington's disease.bioRxiv2023
37160117Interleukin-3 coordinates glial-peripheral immune crosstalk to incite multiple sclerosis.Immunity2023
37315746Immunomodulation of the donor lung with CRISPR-mediated activation of IL-10 expression.J Heart Lung Transplant2023
37312453Rescue of hearing by adenine base editing in a humanized mouse model of Usher syndrome type 1F.Mol Ther2023
36945419PAM-Flexible Genome Editing with an Engineered Chimeric Cas9.Res Sq2023
37162872Base editing strategies to convert CAG to CAA diminish the disease-causing mutation in Huntington's disease.bioRxiv2023
36718090SPTSSA variants alter sphingolipid synthesis and cause a complex hereditary spastic paraplegia.Brain2023
36711797Base editing as a genetic treatment for spinal muscular atrophy.bioRxiv2023
36685559CRISPR-Cas9-AAV versus lentivector transduction for genome modification of X-linked severe combined immunodeficiency hematopoietic stem cells.Front Immunol2023
36711707In situ architecture of Opa1-dependent mitochondrial cristae remodeling.bioRxiv2023
36593413Precise cut-and-paste DNA insertion using engineered type V-K CRISPR-associated transposases.Nat Biotechnol2023
36928188Multimodal CRISPR perturbations of GWAS loci associated with coronary artery disease in vascular endothelial cells.PLoS Genet2023
36203014Precise DNA cleavage using CRISPR-SpRYgests.Nat Biotechnol2023
36378874Expanding the Scope of Bacterial CRISPR Activation with PAM-Flexible dCas9 Variants.ACS Synth Biol2022
35572197CRISPR-Cas knockout of miR21 reduces glioma growth.Mol Ther Oncolytics2022
35623354Lack of Cas13a inhibition by anti-CRISPR proteins from Leptotrichia prophages.Mol Cell2022
35552388Genome editing in animals with minimal PAM CRISPR-Cas9 enzymes.Nat Commun2022
36040815Allele-specific silencing of the gain-of-function mutation in Huntington's disease using CRISPR/Cas9.JCI Insight2022
33002419enAsCas12a Enables CRISPR-Directed Evolution to Screen for Functional Drug Resistance Mutations in Sequences Inaccessible to SpCas9.Mol Ther2021
33547443Scalable characterization of the PAM requirements of CRISPR-Cas enzymes using HT-PAMDA.Nat Protoc2021
33623984Enhanced homology-directed repair for highly efficient gene editing in hematopoietic stem/progenitor cells.Blood2021
33887194Whole-genome sequencing association analysis of quantitative red blood cell phenotypes: The NHLBI TOPMed program.Am J Hum Genet2021
34563399Making the cut with PAMless CRISPR-Cas enzymes.Trends Genet2021
34262178Astrocytic interleukin-3 programs microglia and limits Alzheimer's disease.Nature2021
34233163NNT mediates redox-dependent pigmentation via a UVB- and MITF-independent mechanism.Cell2021
34087167Whole-genome sequencing association analysis of quantitative red blood cell phenotypes: The NHLBI TOPMed program.Am J Hum Genet2021
34086870CRISPR-targeted MAGT1 insertion restores XMEN patient hematopoietic stem cells and lymphocytes.Blood2021
33402735Plant genome editing branches out.Nat Plants2021
32661438Optimization of AsCas12a for combinatorial genetic screens in human cells.Nat Biotechnol2021
32161326In vivo engineering of lymphocytes after systemic exosome-associated AAV delivery.Sci Rep2020
32900862Cell-based artificial APC resistant to lentiviral transduction for efficient generation of CAR-T cells from various cell sources.J Immunother Cancer2020
32218510Broad-spectrum anti-CRISPR proteins facilitate horizontal gene transfer.Nat Microbiol2020
32217751Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants.Science2020
32327734Author Correction: Broad-spectrum anti-CRISPR proteins facilitate horizontal gene transfer.Nat Microbiol2020
32325050Listeria Phages Induce Cas9 Degradation to Protect Lysogenic Genomes.Cell Host Microbe2020
32541959Publisher Correction: Engineered CRISPR-Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing.Nat Biotechnol2020
30742127Engineered CRISPR-Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing.Nat Biotechnol2019
29972722Activities and specificities of CRISPR/Cas9 and Cas12a nucleases for targeted mutagenesis in maize.Plant Biotechnol J2019
31562479Voices in methods development.Nat Methods2019
29724820Temporal and Spatial Post-Transcriptional Regulation of Zebrafish <i>tie1</i> mRNA by Long Noncoding RNA During Brain Vascular Assembly.Arterioscler Thromb Vasc Biol2018
29998038Prediction of off-target activities for the end-to-end design of CRISPR guide RNAs.Nat Biomed Eng2018
30190308Discovery of widespread type I and type V CRISPR-Cas inhibitors.Science2018
29858078CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer's Disease.Mol Ther Nucleic Acids2018
28931002Enhanced proofreading governs CRISPR-Cas9 targeting accuracy.Nature2017
28415827Camptothecin resistance is determined by the regulation of topoisomerase I degradation mediated by ubiquitin proteasome pathway.Oncotarget2017
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Collaborators

J Keith Joung
Massachusetts General Hospital
Co-authored papers 19
Joseph Bondy-Denomy
University of California san francisco
Co-authored papers 5
Luca Pinello
Co-authored papers 3
Guillaume Lettre
Co-authored papers 3
Xiaolin Wu
Leidos Biomedical Research Inc.
Co-authored papers 3
Albert V Smith
University of Michigan School of Public Health ann arbor
Co-authored papers 2
Yao Hu
Co-authored papers 2
Adrienne M Stilp
Co-authored papers 2
Deborah A Nickerson
University of Washington
Co-authored papers 2
Kari E North
Co-authored papers 2
Nancy L Heard-Costa
Co-authored papers 2
Adam S Butterworth
British Heart Foundation Cardiovascular Epidemiology Unit, University of Cambridge
Co-authored papers 2
David R Liu
Co-authored papers 2
Ruth J F Loos
Co-authored papers 2
Stacey Gabriel
Broad Institute of MIT and Harvard
Co-authored papers 2
Cathy C Laurie
Co-authored papers 2
Thomas W Blackwell
Co-authored papers 2
Braxton D Mitchell
Co-authored papers 2
Alanna C Morrison
Co-authored papers 2
Eric Jorgenson
Co-authored papers 2
Lifang Hou
Co-authored papers 2
Matthew P Conomos
Co-authored papers 2
Leslie A Lange
Co-authored papers 2
Jennifer A Brody
Co-authored papers 2
Matthew H Porteus
Stanford University
Co-authored papers 2
Nathan Pankratz
University of Minnesota
Co-authored papers 2
Sandra Burkett
Center for Cancer Research, National Cancer Institute, National Institutes of Health
Co-authored papers 2
Bruce M Psaty
Co-authored papers 2
Paul S de Vries
Co-authored papers 2
Joshua P Lewis
Co-authored papers 2
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