Author details

Full Name

Jason D Ulrich

Affiliation

ORCID

Career Start Year

2010

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37172094	TREM2 inhibition triggers antitumor cell activity of myeloid cells in glioblastoma.		2023
36368315	TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4.	Neuron	2023
36219197	Chronic TREM2 activation exacerbates AÎ²-associated tau seeding and spreading.	Journal of Experimental Medicine	2023
37995685	Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist.		2023
38086389	APOE3ch alters microglial response and suppresses AÎ²-induced tau seeding and spread.		2023
37562846	Parenchymal border macrophages regulate tau pathology and tau-mediated neurodegeneration.	Life Sci Alliance	2023
37279069	APOE-Îµ4 synergizes with sleep disruption to accelerate AÎ² deposition and AÎ²-associated tau seeding and spreading.		2023
36890231	Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy.	Nature	2023
36634180	ApoE isoform- and microbiota-dependent progression of neurodegeneration in a mouse model of tauopathy.	Science	2023
35109920	Selective reduction of astrocyte apoE3 and apoE4 strongly reduces AÎ² accumulation and plaque-related pathology in a mouse model of amyloidosis.	Molecular Neurodegeneration	2022
36397070	TREM2 and microglia exosomes: a potential highway for pathological tau.	Molecular Neurodegeneration	2022
33550655	Apolipoprotein E4 Reduction with Antisense Oligonucleotides Decreases Neurodegeneration in a Tauopathy Model.	Ann Neurol	2021
34289347	Neuronal VCP loss of function recapitulates FTLD-TDP pathology.	Cell Reports	2021
34157306	Overexpressing low-density lipoprotein receptor reduces tau-associated neurodegeneration in relation to apoE-linked mechanisms.	Neuron	2021
34100905	Activated microglia mitigate AÎ²-associated tau seeding and spreading.	Journal of Experimental Medicine	2021
33831349	Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia.	Neuron	2021
34133945	C9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation.	Neuron	2021
33597265	APOE immunotherapy reduces cerebral amyloid angiopathy and amyloid plaques while improving cerebrovascular function.	Science Translational Medicine	2021
32544086	Impact of TREM2R47H variant on tau pathology-induced gliosis and neurodegeneration.	Journal of Clinical Investigation	2020
32024799	genotype regulates pathology and disease progression in synucleinopathy.	Science Translational Medicine	2020
32409732	Author Correction: Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease.	Nat Med	2020
31932797	Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease.	Nat Med	2020
31024116	Senescent glia spell trouble in Alzheimer's disease.	Nature Neuroscience	2019
31623648	Lack of hepatic apoE does not influence early AÎ² deposition: observations from a new APOE knock-in model.	Molecular Neurodegeneration	2019
31235932	TREM2 function impedes tau seeding in neuritic plaques.	Nat Neurosci	2019
29600961	Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation.	J Clin Invest	2018
29040522	Behavioral and transcriptomic analysis of Trem2-null mice: not all knockout mice are created equal.	Human Molecular Genetics	2018
30341064	High-affinity interactions and signal transduction between AÎ² oligomers and TREM2.	EMBO Mol Med	2018
29483128	ApoE facilitates the microglial response to amyloid plaque pathology.	Journal of Experimental Medicine	2018
28246336	Apolipoprotein E and Alzheimer's disease: the influence of apolipoprotein E on amyloid-Î² and other amyloidogenic proteins.	Journal of Lipid Research	2017
28426958	Elucidating the Role of TREM2 in Alzheimer's Disease.	Neuron	2017
28424326	Anti-tau antibody administration increases plasma tau in transgenic mice and patients with tauopathy.	Sci Transl Med	2017
28802038	TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease.	Cell	2017
28930663	The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.	Immunity	2017
29216448	Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of Î²-amyloidosis.	Neuron	2017
29073081	TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy.	Proceedings of the National Academy of Sciences of the United States of America	2017
27559087	Novel allele-dependent role for APOE in controlling the rate of synapse pruning by astrocytes.	Proc Natl Acad Sci U S A	2016
27091843	TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques.	Journal of Experimental Medicine	2016
26854967	TREM2 Function in Alzheimer's Disease and Neurodegeneration.	ACS Chemical Neuroscience	2016
26494271	Re-evaluation of the Blood-Brain Barrier in the Presence of Alzheimer's Disease Pathology.	Neuron	2015
25728668	TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model.	Cell	2015
24893973	Altered microglial response to AÎ² plaques in APPPS1-21 mice heterozygous for TREM2.	Molecular Neurodegeneration	2014
25231981	Nerve growth factor (NGF) regulates activity of nuclear factor of activated T-cells (NFAT) in neurons via the phosphatidylinositol 3-kinase (PI3K)-Akt-glycogen synthase kinase 3Î² (GSK3Î²) pathway.	Journal of Biological Chemistry	2014
23704555	Comment on "ApoE-directed therapeutics rapidly clear Î²-amyloid and reverse deficits in AD mouse models".	Science	2013
23601557	In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis.	Molecular Neurodegeneration	2013
22977251	Distinct activation properties of the nuclear factor of activated T-cells (NFAT) isoforms NFATc3 and NFATc4 in neurons.	Journal of Biological Chemistry	2012
20071509	Postsynaptic clustering and activation of Pyk2 by PSD-95.	Journal of Neuroscience	2010
19942860	Assembly of a beta2-adrenergic receptor--GluR1 signalling complex for localized cAMP signalling.	EMBO Journal	2010