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Author Details

Charles Swanton
Francis Crick Institute
1997
353
98
PMIDPaper TitleJournal TitlePublished Year
38049664The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance.Nat Genet2024
38017136CONIPHER: a computational framework for scalable phylogenetic reconstruction with error correction.Nat Protoc2024
38070528SARS-CoV-2 mucosal neutralising immunity after vaccination.Lancet Infect Dis2024
37793085MyPathway Human Epidermal Growth Factor Receptor 2 Basket Study: Pertuzumab + Trastuzumab Treatment of a Tissue-Agnostic Cohort of Patients With Human Epidermal Growth Factor Receptor 2-Altered Advanced Solid Tumors.J Clin Oncol2024
36316952Multi-cancer early detection test sensitivity for cancers with and without current population-level screening options.Tumori2023
37758959Tumor heterogeneity impairs immunogenicity in mismatch repair deficient tumors.Nat Genet2023
37914385Quantifying the impact of immunotherapy on RNA dynamics in cancer.J Immunother Cancer2023
37745558Decoding biological age from face photographs using deep learning.medRxiv2023
37742469Placing the patient at the heart of discovery science.Eur J Cancer2023
37880414Turning a failing PhD around.Nat Cancer2023
37820584Cancer cell-intrinsic mechanisms driving acquired immune tolerance.Immunity2023
37871126Refphase: Multi-sample phasing reveals haplotype-specific copy number heterogeneity.PLoS Comput Biol2023
37192000Human endogenous retrovirus onco-exaptation counters cancer cell senescence through calbindin.J Clin Invest2023
37059687Insights into the metastatic cascade through research autopsies.Trends Cancer2023
37059064Impact of risk factors on early cancer evolution.Cell2023
37290472Neutralising immunity to omicron sublineages BQ.1.1, XBB, and XBB.1.5 in healthy adults is boosted by bivalent BA.1-containing mRNA vaccination and previous Omicron infection.Lancet Infect Dis2023
37217651The proteasome regulator PSME4 modulates proteasome activity and antigen diversity to abrogate antitumor immunity in NSCLC.Nat Cancer2023
37086716Early immune pressure initiated by tissue-resident memory T cells sculpts tumor evolution in non-small cell lung cancer.Cancer Cell2023
37348521Independent SARS-CoV-2 staff testing protected academic and health-care institutions in northwest London.Lancet2023
37185463Modelled mortality benefits of multi-cancer early detection screening in England.Br J Cancer2023
37248301Pan-cancer T cell atlas links a cellular stress response state to immunotherapy resistance.Nat Med2023
37116490Sotrovimab restores neutralization against current Omicron subvariants in patients with blood cancer.Cancer Cell2023
37245210ALDH1L2 regulation of formate, formyl-methionine, and ROS controls cancer cell migration and metastasis.Cell Rep2023
37342197Phenotyping of lymphoproliferative tumours generated in xenografts of non-small cell lung cancer.Front Oncol2023
37178708Utility of polygenic risk scores in UK cancer screening: a modelling analysis.Lancet Oncol2023
36977461Late-Stage Metastatic Melanoma Emerges through a Diversity of Evolutionary Pathways.Cancer Discov2023
37292842Within-host SARS-CoV-2 viral kinetics informed by complex life course exposures reveals different intrinsic properties of Omicron and Delta variants.medRxiv2023
36789568Distinct Mutagenic Activity of APOBEC3G Cytidine Deaminase Identified in Bladder Cancer.Cancer Res2023
36853169Spatial Positioning of Immune Hotspots Reflects the Interplay between B and T Cells in Lung Squamous Cell Carcinoma.Cancer Res2023
36780531An HLA-G/SPAG9/STAT3 axis promotes brain metastases.Proc Natl Acad Sci U S A2023
36930945Clonal Evolution in Healthy and Premalignant Tissues: Implications for Early Cancer Interception Strategies.Cancer Prev Res (Phila)2023
36827978Intratumoral CD8<sup>+</sup> T cells with a tissue-resident memory phenotype mediate local immunity and immune checkpoint responses in breast cancer.Cancer Cell2023
36495927Performance of a targeted methylation-based multi-cancer early detection test by race and ethnicity.Prev Med2023
34876409Atezolizumab Treatment of Tumors with High Tumor Mutational Burden from MyPathway, a Multicenter, Open-Label, Phase IIa Multiple Basket Study.Cancer Discov2022
35731890CKS1 inhibition depletes leukemic stem cells and protects healthy hematopoietic stem cells in acute myeloid leukemia.Sci Transl Med2022
35697807Estimation of tumor cell total mRNA expression in 15 cancer types predicts disease progression.Nat Biotechnol2022
35425962Combinatorial Inactivation of Tumor Suppressors Efficiently Initiates Lung Adenocarcinoma with Therapeutic Vulnerabilities.Cancer Res2022
35487215The translational challenges of precision oncology.Cancer Cell2022
35413273Immune responses following third COVID-19 vaccination are reduced in patients with hematological malignancies compared to patients with solid cancer.Cancer Cell2022
36400018Evaluation of cell-free DNA approaches for multi-cancer early detection.Cancer Cell2022
36209762WHO's Therapeutics and COVID-19 Living Guideline on mAbs needs to be reassessed.Lancet2022
36240755Functional immune responses against SARS-CoV-2 variants of concern after fourth COVID-19 vaccine dose or infection in patients with blood cancer.Cell Rep Med2022
36131011Leveraging extrachromosomal DNA to fine-tune trials of targeted therapy for glioblastoma: opportunities and challenges.Nat Rev Clin Oncol2022
35930804An Immunogenic Model of KRAS-Mutant Lung Cancer Enables Evaluation of Targeted Therapy and Immunotherapy Combinations.Cancer Res2022
35895836SARS-CoV-2 S2-targeted vaccination elicits broadly neutralizing antibodies.Sci Transl Med2022
36230741Cell-Free DNA-Based Multi-Cancer Early Detection Test in an Asymptomatic Screening Population (NHS-Galleri): Design of a Pragmatic, Prospective Randomised Controlled Trial.Cancers (Basel)2022
36163168RAS oncogenic activity predicts response to chemotherapy and outcome in lung adenocarcinoma.Nat Commun2022
36123406The evolutionary dynamics of extrachromosomal DNA in human cancers.Nat Genet2022
36289203Clonal somatic copy number altered driver events inform drug sensitivity in high-grade serous ovarian cancer.Nat Commun2022
36376909MEDICC2: whole-genome doubling aware copy-number phylogenies for cancer evolution.Genome Biol2022
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Collaborators

David Nicol
The Royal Marsden Hospital
Co-authored papers 14
Peter Van Loo
The Francis Crick Institute
Co-authored papers 12
Phillip A Futreal
The University of Texas MD Anderson Cancer Center
Co-authored papers 11
David A Moore
University College London Cancer Institute
Co-authored papers 10
John Le Quesne
Beatson Cancer Research Institute, University of Glasgow
Co-authored papers 10
Nicholas van As
The Institute of Cancer Research, Royal Marsden NHS Foundation Trust
Co-authored papers 9
Steven Hazell
Royal Marsden NHS Foundation Trust
Co-authored papers 9
Richard Mitter
The Francis Crick Institute
Co-authored papers 8
Jorge S Reis-Filho
Memorial Sloan-Kettering Cancer Center
Co-authored papers 7
Paul A Bates
The Francis Crick Institute
Co-authored papers 7
Funda Meric-Bernstam
University of Texas MD Anderson Cancer Center
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Dean A Fennell
University of Leicester
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Qiyuan Li
National Institute of Data Science in Health and Medicine, Xiamen University
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Washington University School of Medicine
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Apostolos Nakas
University Hospitals of Leicester NHS Trust
Co-authored papers 5
Francesco Favero
Universita del Piemonte Orientale
Co-authored papers 5
Andrea L Richardson
Co-authored papers 4
Nic Jones
Cancer Research United Kingdom Manchester Institute, University of Manchester
Co-authored papers 4
Fiona Blackhall
The University of Manchester
Co-authored papers 4
Mary S Beattie
University of California san francisco
Co-authored papers 4
Christos Sotiriou
Co-authored papers 4
Terence P Speed
Co-authored papers 4
Susana Banerjee
The Royal Marsden NHS Foundation Trust and Institute of Cancer Research
Co-authored papers 4
Clare Turnbull
Institute of Cancer Research
Co-authored papers 4
Albrecht Stenzinger
Institute of Pathology, University Hospital Heidelberg
Co-authored papers 4
Simon J Boulton
The Francis Crick Institute
Co-authored papers 3
Release 1.2