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Author Details

James W Dennis
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University Avenue R988
1980
211
68
PMIDPaper TitleJournal TitlePublished Year
34515014Molecular and Metabolomic Investigation of Celecoxib Antiproliferative Activity in Mono-and Combination Therapy against Breast Cancer Cell Models.Anticancer Agents Med Chem2022
35528547Age-associated impairment of T cell immunity is linked to sex-dimorphic elevation of N-glycan branching.Nat Aging2022
33970182Association of a Marker of N-Acetylglucosamine With Progressive Multiple Sclerosis and Neurodegeneration.JAMA Neurol2021
33894774Glioma stem cells invasive phenotype at optimal stiffness is driven by MGAT5 dependent mechanosensing.J Exp Clin Cancer Res2021
32694731Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.Nat Metab2020
33060361The GATOR-Rag GTPase pathway inhibits mTORC1 activation by lysosome-derived amino acids.Science2020
33453988N-acetylglucosamine drives myelination by triggering oligodendrocyte precursor cell differentiation.J Biol Chem2020
30579457Identification of unique characteristics and the management of blunt traumatic aortic injuries occurring at unusual locations in the descending thoracic aorta.J Vasc Surg2019
31803361Caveolin-1 Y14 phosphorylation suppresses tumor growth while promoting invasion.Oncotarget2019
30913278Increasing cell permeability of N-acetylglucosamine via 6-acetylation enhances capacity to suppress T-helper 1 (TH1)/TH17 responses and autoimmunity.PLoS One2019
29167019Reassessing the utility of CT angiograms in penetrating injuries to the extremities.Surgery2018
30002126N-linked glycosylation modulates the immunogenicity of recombinant human factor VIII in hemophilia A mice.Haematologica2018
29649217The UBR-1 ubiquitin ligase regulates glutamate metabolism to generate coordinated motor pattern in Caenorhabditis elegans.PLoS Genet2018
29766144Novel application of an old technique: the use of external to internal carotid artery transposition in trauma.Trauma Surg Acute Care Open2018
27872092Plk4 Promotes Cancer Invasion and Metastasis through Arp2/3 Complex Regulation of the Actin Cytoskeleton.Cancer Res2017
29048482N-acetylglucosamine: more than a silent partner in insulin resistance.Glycobiology2017
28923586Genetic code asymmetry supports diversity through experimentation with posttranslational modifications.Curr Opin Chem Biol2017
28716093C. elegans SUP-46, an HNRNPM family RNA-binding protein that prevents paternally-mediated epigenetic sterility.BMC Biol2017
28817611The directed migration of gonadal distal tip cells in Caenorhabditis elegans requires NGAT-1, a ÿ1,4-N-acetylgalactosaminyltransferase enzyme.PLoS One2017
26972830Metabolic Reprogramming by Hexosamine Biosynthetic and Golgi N-Glycan Branching Pathways.Sci Rep2016
27329152Mgat5 modulates the effect of early life stress on adult behavior and physical health in mice.Behav Brain Res2016
27323329PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia.Nat Cell Biol2016
25174401A novel role for Plk4 in regulating cell spreading and motility.Oncogene2015
26439532Many Light Touches Convey the Message.Trends Biochem Sci2015
26092931The galectin lattice at a glance.J Cell Sci2015
25852190Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.Sci Signal2015
25395405Golgi N-glycan branching N-acetylglucosaminyltransferases I, V and VI promote nutrient uptake and metabolism.Glycobiology2015
24475074Encoding asymmetry of the N-glycosylation motif facilitates glycoprotein evolution.PLoS One2014
25201272Targeted metabolomics in cultured cells and tissues by mass spectrometry: method development and validation.Anal Chim Acta2014
24742675N-glycan remodeling on glucagon receptor is an effector of nutrient sensing by the hexosamine biosynthesis pathway.J Biol Chem2014
23378517Density-dependent lectin-glycan interactions as a paradigm for conditional regulation by posttranslational modifications.Mol Cell Proteomics2013
23875632Probing the hexosamine biosynthetic pathway in human tumor cells by multitargeted tandem mass spectrometry.ACS Chem Biol2013
23846654Temporal regulation of EGF signalling networks by the scaffold protein Shc1.Nature2013
22083685The eggshell in the C. elegans oocyte-to-embryo transition.Genesis2012
22957033Suppression of cancer progression by MGAT1 shRNA knockdown.PLoS One2012
22846995Galectin-3 protein regulates mobility of N-cadherin and GM1 ganglioside at cell-cell junctions of mammary carcinoma cells.J Biol Chem2012
22633423A prospective randomized study comparing fibrin sealant to manual compression for the treatment of anastomotic suture-hole bleeding in expanded polytetrafluoroethylene grafts.J Vasc Surg2012
22325667Diagnosis and management of evacuated casualties with cervical vascular injuries resulting from combat-related explosive blasts.J Vasc Surg2012
21616652Glycosylation, galectins and cellular signaling.Curr Opin Cell Biol2011
22180208High-throughput lectin magnetic bead array-coupled tandem mass spectrometry for glycoprotein biomarker discovery.Electrophoresis2011
21629267Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis.Nat Commun2011
20348415Plk4 is required for cytokinesis and maintenance of chromosomal stability.Proc Natl Acad Sci U S A2010
21106670The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism.Genes Dev2010
20971008Eggshell chitin and chitin-interacting proteins prevent polyspermy in C. elegans.Curr Biol2010
20668475Aberrant O-GlcNAcylation characterizes chronic lymphocytic leukemia.Leukemia2010
19438805Caveolin-1 regulation of dynamin-dependent, raft-mediated endocytosis of cholera toxin-B sub-unit occurs independently of caveolae.J Cell Mol Med2009
20064370Metabolism, cell surface organization, and disease.Cell2009
19761541Adaptive regulation at the cell surface by N-glycosylation.Traffic2009
19398762Lattices, rafts, and scaffolds: domain regulation of receptor signaling at the plasma membrane.J Cell Biol2009
17680692Biological implications of SNPs in signal peptide domains of human proteins.Proteins2008
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Collaborators

Air Quality Modelling and Integration Research Unit
Co-authored papers 10
University of Perugia
Co-authored papers 9
Vanderbilt University School of Medicine
Co-authored papers 7
University of Toronto, Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital
Co-authored papers 7
Lunenfeld-Tanenbaum Research Institute Mount Sinai Hospital
Co-authored papers 6
Lunenfeld-Tanenbaum Research Institute
Co-authored papers 5
Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital
Co-authored papers 5
Hospital for Sick Children, University of Toronto
Co-authored papers 4
Princess Margaret Cancer Centre
Co-authored papers 3
University of Toronto
Co-authored papers 2
Max-Delbruck Center for Molecular Medicine in the Helmholtz Association
Co-authored papers 2
The Scripps Research Institute
Co-authored papers 2
Princess Margaret Cancer Centre
Co-authored papers 2
College of Life Sciences and Agriculture, University of New Hampshire
Co-authored papers 2
Co-authored papers 2
Co-authored papers 2
University of Waterloo, University Avenue West
Co-authored papers 2
Max-Delbruck Center for Molecular Medicine in the Helmholtz Association
Co-authored papers 2
Princess Margaret Cancer Centre
Co-authored papers 2
Mount Sinai Hospital
Co-authored papers 2
Co-authored papers 2
Co-authored papers 2
The Hospital for Sick Children, University Avenue
Co-authored papers 2
Co-authored papers 2
Memorial University
Co-authored papers 1
Charite School of Medicine and University Hospital Berlin
Co-authored papers 1
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
Co-authored papers 1
University of Sao Paulo
Co-authored papers 1
Institute of Medical Science, University of Toronto
Co-authored papers 1
University of Toronto
Co-authored papers 1