Author details

Full Name

Hai Yan

Affiliation

ORCID

Career Start Year

1994

Papers

166

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36932248	Publisher Correction: Glucagon receptor antagonist volagidemab in type 1 diabetes: a 12-week, randomized, double-blind, phase 2 trial.		2023
37612270	Author Correction: Identification of recurrent USP48 and BRAF mutations in Cushing's disease.		2023
37008903	Sleeve gastrectomy decreases high-fat diet induced colonic pro-inflammatory status through the gut microbiota alterations.		2023
36192552	Glucagon receptor antagonist volagidemab in type 1 diabetes: a 12-week, randomized, double-blind, phase 2 trial.	Nature Medicine	2022
35789836	Pro-Î±-cell-derived Î²-cells contribute to Î²-cell neogenesis induced by antagonistic glucagon receptor antibody in type 2 diabetic mice.	iScience	2022
34720085	Dual role of allele-specific DNA hypermethylation within the TERT promoter in cancer.	J Clin Invest	2021
33576297	Targeting the glucagon receptor signaling pathway as a novel strategy to counteract PI3K inhibitor induced hyperglycemia while sustaining tumor PI3K inhibition.	Leukemia and Lymphoma	2021
33441554	Very low mutation burden is a feature of inflamed recurrent glioblastomas responsive to cancer immunotherapy.	Nat Commun	2021
34131315	The implications of IDH mutations for cancer development and therapy.	Nature Reviews Clinical Oncology	2021
32883741	Targeting Isocitrate Dehydrogenase Mutations in Cancer: Emerging Evidence and Diverging Strategies.	Clinical Cancer Research	2021
34465679	Mutation at a new allele of the dysferlin gene causes Miyoshi myopathy: A case report.	Journal of Musculoskeletal Neuronal Interactions	2021
34732238	TP53 wild-type/PPM1D mutant diffuse intrinsic pontine gliomas are sensitive to a MDM2 antagonist.	Acta neuropathologica communications	2021
32555164	The integrated genomic and epigenomic landscape of brainstem glioma.	Nature Communications	2020
32229503	Targeting Mutant PPM1D Sensitizes Diffuse Intrinsic Pontine Glioma Cells to the PARP Inhibitor Olaparib.	Molecular Cancer Research	2020
31551363	Genome-Wide CRISPR-Cas9 Screen Reveals Selective Vulnerability of -Mutant Cancers to WEE1 Inhibition.	Cancer Research	2020
32457631	Efficacy and Side Effects of Drugs Commonly Used for the Treatment of Lower Urinary Tract Symptoms Associated With Benign Prostatic Hyperplasia.	Frontiers in Pharmacology	2020
33139340	Hitting Gliomas When They Are Down: Exploiting IDH-Mutant Metabolic Vulnerabilities.	Cancer Discovery	2020
32561493	Glucagon receptor antagonism promotes the production of gut proglucagon-derived peptides in diabetic mice.	Peptides	2020
30932912	DNA hypermethylation within TERT promoter upregulates TERT expression in cancer.	J Clin Invest	2019
31595305	The potential of cerebrospinal fluid-based liquid biopsy approaches in CNS tumors.	Neuro Oncol	2019
30460397	Molecular profiling of tumors of the brainstem by sequencing of CSF-derived circulating tumor DNA.	Acta Neuropathologica	2019
30358567	DNA hypermethylation within TERT promoter upregulates TERT expression in cancer.	J Clin Invest	2019
30346624	Sensitive and rapid detection of TERT promoter and IDH mutations in diffuse gliomas.	Neuro-Oncology	2019
30097251	A machine learning-based prediction model of H3K27M mutations in brainstem gliomas using conventional MRI and clinical features.	Radiotherapy and Oncology	2019
30478739	Hereditary brain tumor with a homozygous germline mutation in PMS2: pedigree analysis and prenatal screening in a family with constitutional mismatch repair deficiency (CMMRD) syndrome.	Familial Cancer	2019
30626440	Targeting the glucagon receptor improves cardiac function and enhances insulin sensitivity following a myocardial infarction.	Cardiovascular Diabetology	2019
31292202	CRISPR Editing of Mutant IDH1 R132H Induces a CpG Methylation-Low State in Patient-Derived Glioma Models of G-CIMP.	Molecular Cancer Research	2019
31040154	MTAP Loss Promotes Stemness in Glioblastoma and Confers Unique Susceptibility to Purine Starvation.	Cancer Research	2019
30858324	Detection of early-stage hepatocellular carcinoma in asymptomatic HBsAg-seropositive individuals by liquid biopsy.	Proc Natl Acad Sci U S A	2019
30856613	Non-invasive sensitive brain tumor detection using dual-modality bioimaging nanoprobe.	Nanotechnology	2019
31061918	Glucagon Receptor Antagonism Ameliorates Progression of Heart Failure.	JACC: Basic to Translational Science	2019
31203188	Antagonistic Glucagon Receptor Antibody Promotes Î±-Cell Proliferation and Increases Î²-Cell Mass in Diabetic Mice.	iScience	2019
31533041	A PRMT5-RNF168-SMURF2 Axis Controls H2AX Proteostasis.	Cell Reports	2019
29802247	The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma.	Nat Commun	2018
30266879	Correction: Reversing the Warburg effect as a treatment for glioblastoma.	Journal of Biological Chemistry	2018
29929473	A Chinese family affected by lynch syndrome caused by MLH1 mutation.	BMC Medical Genetics	2018
30093687	Identification of recurrent USP48 and BRAF mutations in Cushing's disease.	Nature Communications	2018
30131529	Mutant allele quantification reveals a genetic basis for TP53 mutation-driven castration resistance in prostate cancer cells.	Sci Rep	2018
29855600	Improved grading of IDH-mutated astrocytic gliomas.	Nature Reviews Neurology	2018
30034587	Synthesis and Evaluation of a F-Labeled Triazinediamine Analogue for Imaging Mutant IDH1 Expression in Gliomas by PET.	ACS Medicinal Chemistry Letters	2018
29097607	Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1-Induced Metabolic Liabilities.	Cancer Research	2018
29444429	Glucagon Receptor Antagonism Improves Glucose Metabolism and Cardiac Function by Promoting AMP-Mediated Protein Kinase in Diabetic Mice.	Cell Reports	2018
29366652	Synthesis and evaluation of radiolabeled AGI-5198 analogues as candidate radiotracers for imaging mutant IDH1 expression in tumors.	Bioorganic and Medicinal Chemistry Letters	2018
29283470	Effect of a glucagon receptor antibody (REMD-477) in type 1 diabetes: A randomized controlled trial.	Diabetes, Obesity and Metabolism	2018
29805076	Biological Role and Therapeutic Potential of IDH Mutations in Cancer.	Cancer Cell	2018
27871808	New mechanism of lipotoxicity in diabetic cardiomyopathy: Deficiency of Endogenous HS Production and ER stress.	Mechanisms of Ageing and Development	2017
28591638	Interrupted Glucagon Signaling Reveals Hepatic Î± Cell Axis and Role for L-Glutamine in Î± Cell Proliferation.	Cell Metab	2017
28939681	Loss Promotes Gliomagenesis via Aberrant Neural Stem Cell Proliferation and Differentiation.	Cancer Research	2017
28413019	Germline Mutations in CDH23, Encoding Cadherin-Related 23, Are Associated with Both Familial and Sporadic Pituitary Adenomas.	American Journal of Human Genetics	2017
28323959	Insulin and Glucagon: Partners for Life.	Endocrinology	2017