Author details

Full Name

Christopher D Lima

Affiliation

Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center

ORCID

Career Start Year

1993

Papers

126

H Index

Expertise

CM4AI Collaborator

Andrej Sali (CM4AI)

PMID	Paper Title	Journal Title	Published Year
35058317	YTHDC2 control of gametogenesis requires helicase activity but not m<sup>6</sup>A binding.	Genes Dev	2022
35688134	Structural basis for RNA surveillance by the human nuclear exosome targeting (NEXT) complex.	Cell	2022
35965016	Methods to assess helicase and translocation activities of human nuclear RNA exosome and RNA adaptor complexes.	Methods Enzymol	2022
33147539	RNA helicases are hubs that orchestrate exosome-dependent 3'-5' decay.	Curr Opin Struct Biol	2021
33782132	Substrate discrimination and quality control require each catalytic activity of TRAMP and the nuclear RNA exosome.	Proc Natl Acad Sci U S A	2021
33527832	Whole Cell Active Inhibitors of Mycobacterial Lipoamide Dehydrogenase Afford Selectivity over the Human Enzyme through Tight Binding Interactions.	ACS Infect Dis	2021
34585421	DNA asymmetry promotes SUMO modification of the single-stranded DNA-binding protein RPA.	EMBO J	2021
31879344	Substrate selectivity by the exonuclease Rrp6p.	Proc Natl Acad Sci U S A	2020
31768991	Reconstitution of the Human Nuclear RNA Exosome.	Methods Mol Biol	2020
31768990	Reconstitution of the Schizosaccharomyces pombe RNA Exosome.	Methods Mol Biol	2020
31768989	Reconstitution of S. cerevisiae RNA Exosome Complexes Using Recombinantly Expressed Proteins.	Methods Mol Biol	2020
31768988	Strategies for Generating RNA Exosome Complexes from Recombinant Expression Hosts.	Methods Mol Biol	2020
31539497	SnapShot: The RNA Exosome.	Cell	2019
31235585	Structural basis for adenylation and thioester bond formation in the ubiquitin E1.	Proc Natl Acad Sci U S A	2019
31397327	Crystal structure of the Schizosaccharomyces pombe U7BR E2-binding region in complex with Ubc7.	Acta Crystallogr F Struct Biol Commun	2019
29360036	<i>ketu</i> mutant mice uncover an essential meiotic function for the ancient RNA helicase YTHDC2.	Elife	2018
30242710	Strategies to Trap Enzyme-Substrate Complexes that Mimic Michaelis Intermediates During E3-Mediated Ubiquitin-Like Protein Ligation.	Methods Mol Biol	2018
29906447	Helicase-Dependent RNA Decay Illuminated by a Cryo-EM Structure of a Human Nuclear RNA Exosome-MTR4 Complex.	Cell	2018
29976752	Discovery and engineering of enhanced SUMO protease enzymes.	J Biol Chem	2018
29844170	Structural basis for MTR4-ZCCHC8 interactions that stimulate the MTR4 helicase in the nuclear exosome-targeting complex.	Proc Natl Acad Sci U S A	2018
28234446	Ubiquitin-like Protein Conjugation: Structures, Chemistry, and Mechanism.	Chem Rev	2018
27899565	The Rrp6 C-terminal domain binds RNA and activates the nuclear RNA exosome.	Nucleic Acids Res	2017
28202538	Targeting RNA for processing or destruction by the eukaryotic RNA exosome and its cofactors.	Genes Dev	2017
28742025	Structure and reconstitution of yeast Mpp6-nuclear exosome complexes reveals that Mpp6 stimulates RNA decay and recruits the Mtr4 helicase.	Elife	2017
27509863	Capturing a substrate in an activated RING E3/E2-SUMO complex.	Nature	2016
27818140	Nuclear RNA Exosome at 3.1Â Ã¿ Reveals Substrate Specificities, RNA Paths, and Allosteric Inhibition of Rrp44/Dis3.	Mol Cell	2016
27203180	Recognition of Lys48-Linked Di-ubiquitin and Deubiquitinating Activities of the SARS Coronavirus Papain-like Protease.	Mol Cell	2016
27385828	Structure and function of the yeast listerin (Ltn1) conserved N-terminal domain in binding to stalled 60S ribosomal subunits.	Proc Natl Acad Sci U S A	2016
25414009	Fission yeast RNA triphosphatase reads an Spt5 CTD code.	RNA	2015
26524494	Structural basis for catalytic activation by the human ZNF451 SUMO E3 ligase.	Nat Struct Mol Biol	2015
25862929	Growing an editorial board for an ever expanding field.	Structure	2015
25883047	Genetic and structural analysis of the essential fission yeast RNA polymerase II CTD phosphatase Fcp1.	RNA	2015
25764917	SARS hCoV papain-like protease is a unique Lys48 linkage-specific di-distributive deubiquitinating enzyme.	Biochem J	2015
24525139	The eukaryotic RNA exosome.	Curr Opin Struct Biol	2014
25043052	Structure of an Rrp6-RNA exosome complex bound to poly(A) RNA.	Nature	2014
24773014	Structural and functional insights to ubiquitin-like protein conjugation.	Annu Rev Biophys	2014
24939935	How an mRNA capping enzyme reads distinct RNA polymerase II and Spt5 CTD phosphorylation codes.	Genes Dev	2014
23319619	Single-particle EM reveals extensive conformational variability of the Ltn1 E3 ligase.	Proc Natl Acad Sci U S A	2013
24251446	Lipoamide channel-binding sulfonamides selectively inhibit mycobacterial lipoamide dehydrogenase.	Biochemistry	2013
23871671	SUMO-2 and PIAS1 modulate insoluble mutant huntingtin protein accumulation.	Cell Rep	2013
24010704	Celebrating 20 years of Structure.	Structure	2013
23416107	Structure of a ubiquitin E1-E2 complex: insights to E1-E2 thioester transfer.	Mol Cell	2013
22194619	Determinants of small ubiquitin-like modifier 1 (SUMO1) protein specificity, E3 ligase, and SUMO-RanGAP1 binding activities of nucleoporin RanBP2.	J Biol Chem	2012
27166440	Structure and Activities of the Eukaryotic RNA Exosome.	Enzymes	2012
22955611	Structural biology: A protein engagement RING.	Nature	2012
22902556	Exo- and endoribonucleolytic activities of yeast cytoplasmic and nuclear RNA exosomes are dependent on the noncatalytic core and central channel.	Mol Cell	2012
22382979	Recognition of SUMO-modified PCNA requires tandem receptor motifs in Srs2.	Nature	2012
21255825	The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates.	Cell	2011
22000504	Structure meets the membrane.	Structure	2011
21713674	Structural components and architectures of RNA exosomes.	Adv Exp Med Biol	2011

1 - 50 of 126

Paul Dominic B Olinares

The Rockefeller University

Career Start Year 2009

Number of shared co-authors 1

Kelly R Molloy

The Rockefeller University

Career Start Year 2006

Number of shared co-authors 1

Ajay A Vashisht

David Geffen School of Medicine, University of California los angeles

Career Start Year 2005

Number of shared co-authors 0

Lisa M Miller Jenkins

National Cancer Institute, National Institutes of Health

Career Start Year 2005

Number of shared co-authors 1

Christopher C Ebmeier

University of Colorado

Career Start Year 2004

Number of shared co-authors 2

Jie Luo

Institute for Systems Biology

Career Start Year 2004

Number of shared co-authors 1

Xiaorong Wang

University of California Irvine

Career Start Year 2003

Number of shared co-authors 1

Yufeng Tong

University of Windsor

Career Start Year 2002

Number of shared co-authors 0

Andrew P VanDemark

University of Pittsburgh

Career Start Year 2000

Number of shared co-authors 0

B Martin Hallberg

Karolinska Institutet

Career Start Year 2000

Number of shared co-authors 13

Jan P Erzberger

UT Southwestern Medical Center

Career Start Year 1998

Number of shared co-authors 1

Nevan J Krogan (CM4AI)

University of California San Francisco

Career Start Year 1998

Number of shared co-authors 9

James A Wohlschlegel

David Geffen School of Medicine, University of California Los Angeles

Career Start Year 1996

Number of shared co-authors 0

Yun Bai

Carnegie Institution for Science

Career Start Year 1996

Number of shared co-authors 1

Andreas Bracher

Max-Planck-Institute of Biochemistry

Career Start Year 1995

Number of shared co-authors 1

Michael J Trnka

Department of Pharmaceutical Chemistry, University of California San Francisco

Career Start Year 1995

Number of shared co-authors 1

Minkyu Kim

University of California san francisco

Career Start Year 1995

Number of shared co-authors 1

John D Gross

Department of Pharmaceutical Chemistry, University of California san francisco

Career Start Year 1995

Number of shared co-authors 1

Kylie J Walters

Center for Cancer Research, National Cancer Institute, National Institutes of Health

Career Start Year 1993

Number of shared co-authors 1

Svetlana Dokudovskaya

CNRS UMR9018, Institut Gustave Roussy, Universite Paris-Saclay

Career Start Year 1992

Number of shared co-authors 3

Jonathan S Weissman

Whitehead Institute for Biomedical Research

Career Start Year 1991

Number of shared co-authors 1

Sirano Dhe-Paganon

Dana-Farber Cancer Institute

Career Start Year 1989

Number of shared co-authors 11

Cheryl H Arrowsmith

University of Toronto

Career Start Year 1989

Number of shared co-authors 13

Liang Tong

Columbia University

Career Start Year 1988

Number of shared co-authors 12

Ronen Marmorstein

Perelman School of Medicine, University of Pennsylvania

Career Start Year 1987

Number of shared co-authors 0

Opher Gileadi

Structural Genomics Consortium Karolinska Institute Stockholm Sweden.

Career Start Year 1984

Number of shared co-authors 11

Aled M Edwards

University of Toronto

Career Start Year 1984

Number of shared co-authors 12

Henning Urlaub

Max Planck Institute for Multidisciplinary Sciences

Career Start Year 1982

Number of shared co-authors 2

J. Wade Harper

Harvard Medical School

Career Start Year 1981

Number of shared co-authors 2

John A Tainer

The University of Texas MD Anderson Cancer Center

Career Start Year 1975

Number of shared co-authors 5

row(s) 1 - 30 of 30

John A Buglino

Sloan Kettering Institute

Co-authored papers 8

Andrej Sali (CM4AI)

University of California San Francisco

Co-authored papers 6

Li Kai Wang

Sloan-Kettering Institute

Co-authored papers 5

Milka Kostic

Dana-Farber Cancer Institute .

Co-authored papers 4

Huib Ovaa

Leiden University Medical Center

Co-authored papers 3

Wayne A Hendrickson

Columbia University

Co-authored papers 3

Jeffrey B Bonanno

Albert Einstein College of Medicine

Co-authored papers 3

Stephen K Burley

The State University of New Jersey

Co-authored papers 3

Lawrence Shapiro

Zuckerman Mind Brain Behaviour Institute

Co-authored papers 2

Mark R Chance

Case Western Reserve University

Co-authored papers 2

Steven C Almo

Albert Einstein College of Medicine

Co-authored papers 2

Subramanyam Swaminathan

Brookhaven National Laboratory

Co-authored papers 2

Jian-Sheng Jiang

Co-authored papers 2

Kevin D'Amico

Co-authored papers 2

Anne R Bresnick

Albert Einstein College of Medicine

Co-authored papers 2

Simon J Boulton

The Francis Crick Institute

Co-authored papers 1

Debra Dunaway-Mariano

University of New Mexico

Co-authored papers 1

Hua Chen

Co-authored papers 1

Eric C Lai

Co-authored papers 1

Uttiya Basu

Columbia University Medical Center

Co-authored papers 1

Ingeborg Feil

Howard Hughes Medical Institute, University of Washington

Co-authored papers 1

Judit Pallos

Jungers Center for Neurosciences, Oregon Health and Science University

Co-authored papers 1

Evangelos Pefanis

Regeneron Pharmaceuticals, Inc.

Co-authored papers 1

David Baker

University of Washington

Co-authored papers 1

Michael S Glickman

Memorial Sloan Kettering Cancer Center

Co-authored papers 1

Bridget Carragher

Columbia University

Co-authored papers 1

F W Studier

Brookhaven National Laboratory

Co-authored papers 1

Leslie M Thompson

Co-authored papers 1

J Michael Sauder

Eli Lilly and Co.

Co-authored papers 1

1 - 30

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