Author details

Full Name

Laura E Herring

Affiliation

ORCID

Career Start Year

1999

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36976643	Discovery of a Potent and Selective Targeted NSD2 Degrader for the Reduction of H3K36me2.	J Am Chem Soc	2023
38019706	Discovery of Potent and Selective WDR5 Proteolysis Targeting Chimeras as Potential Therapeutics for Pancreatic Cancer.	J Med Chem	2023
37634194	Investigation of the Host Kinome Response to Coronavirus Infection Reveals PI3K/mTOR Inhibitors as Betacoronavirus Antivirals.	J Proteome Res	2023
37290445	PLIN5 interacts with FATP4 at membrane contact sites to promote lipid droplet-to-mitochondria fatty acid transport.		2023
37404812	Involvement of extracellular vesicles in the progression, diagnosis, treatment, and prevention of whole-body ionizing radiation-induced immune dysfunction.		2023
36877831	PROTAC Linkerology Leads to an Optimized Bivalent Chemical Degrader of Polycomb Repressive Complex 2 (PRC2) Components.		2023
37193127	Metatranscriptomics analysis reveals a novel transcriptional and translational landscape during Middle East respiratory syndrome coronavirus infection.	iScience	2023
37063293	Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer.	Front Pharmacol	2023
37183204	Development of VHL-recruiting STING PROTACs that suppress innate immunity.		2023
35178554	The role of SPAG1 in the assembly of axonemal dyneins in human airway epithelia.	J Cell Sci	2022
35953888	Metagenomics combined with activity-based proteomics point to gut bacterial enzymes that reactivate mycophenolate.	Gut Microbes	2022
36288299	Cytomegalovirus US28 regulates cellular EphA2 to maintain viral latency.	Science advances	2022
35816155	The synaptosome-associated protein 23 (SNAP23) is necessary for proper myogenesis.	FASEB Journal	2022
35878877	Correction to "Mitochondrial Protease ClpP Is a Target for the Anticancer Compounds ONC201 and Related Analogues".	ACS Chemical Biology	2022
36323248	Multi-omic profiling reveals the ataxia protein sacsin is required for integrin trafficking and synaptic organization.	Cell Rep	2022
35469920	Identification of a reciprocal negative feedback loop between tau-modifying proteins MARK2 kinase and CBP acetyltransferase.	Journal of Biological Chemistry	2022
36393840	Calpain-mediated proteolysis of vimentin filaments is augmented in giant axonal neuropathy fibroblasts exposed to hypotonic stress.	Frontiers in Cell and Developmental Biology	2022
35094334	Green Chemistry Preservation and Extraction of Biospecimens for Multi-omic Analyses.	Methods in Molecular Biology	2022
34415726	A Peptidomimetic Ligand Targeting the Chromodomain of MPP8 Reveals HRP2's Association with the HUSH Complex.	ACS Chemical Biology	2021
33910013	Tau seeds are subject to aberrant modifications resulting in distinct signatures.	Cell Reports	2021
34060252	SPOP and OTUD7A Control EWS-FLI1 Protein Stability to Govern Ewing Sarcoma Growth.	Advanced Science	2021
33580223	Author Correction: Antigen-capturing nanoparticles improve the abscopal effect and cancer immunotherapy.	Nat Nanotechnol	2021
33462436	Listeria monocytogenes upregulates mitochondrial calcium signalling to inhibit LC3-associated phagocytosis as a survival strategy.	Nature Microbiology	2021
33649150	Evidence for the Mycobacterial Mce4 Transporter Being a Multiprotein Complex.	Journal of Bacteriology	2021
34688654	The KRAS-regulated kinome identifies WEE1 and ERK coinhibition as a potential therapeutic strategy in KRAS-mutant pancreatic cancer.	J Biol Chem	2021
34576246	Burn Injury Induces Proinflammatory Plasma Extracellular Vesicles That Associate with Length of Hospital Stay in Women: CRP and SAA1 as Potential Prognostic Indicators.	International Journal of Molecular Sciences	2021
34586829	A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models.	Sci Transl Med	2021
32553168	Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers.	Cell Rep	2020
32023483	Genome-wide Screening Identifies SFMBT1 as an Oncogenic Driver in Cancer with VHL Loss.	Mol Cell	2020
31896573	Mass spectrometry-based selectivity profiling identifies a highly selective inhibitor of the kinase MELK that delays mitotic entry in cancer cells.	J Biol Chem	2020
32004441	THEMIS-SHP1 Recruitment by 4-1BB Tunes LCK-Mediated Priming of Chimeric Antigen Receptor-Redirected T Cells.	Cancer Cell	2020
31831267	Degradation of Polycomb Repressive Complex 2 with an EED-Targeted Bivalent Chemical Degrader.	Cell Chemical Biology	2020
32156701	Reduction of protein phosphatase 2A (PP2A) complexity reveals cellular functions and dephosphorylation motifs of the PP2A/B'Î´ holoenzyme.	Journal of Biological Chemistry	2020
31810986	TBK1 Is a Synthetic Lethal Target in Cancer with Loss.	Cancer Discovery	2020
32690540	Identification of BBOX1 as a Therapeutic Target in Triple-Negative Breast Cancer.	Cancer Discov	2020
30770249	O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3.	Immunity	2019
31682229	Site-specific phosphorylation and caspase cleavage of GFAP are new markers of Alexander disease severity.	eLife	2019
30540191	Dasatinib Is Preferentially Active in the Activated B-Cell Subtype of Diffuse Large B-Cell Lymphoma.	J Proteome Res	2019
31490923	Conservation and divergence of protein pathways in the vertebrate heart.	PLoS Biol	2019
31500803	Positive Cooperativity in Substrate Binding by Human Thymidylate Synthase.	Biophys J	2019
31021596	Mitochondrial Protease ClpP is a Target for the Anticancer Compounds ONC201 and Related Analogues.	ACS Chemical Biology	2019
30665704	Lack of GAS2L2 Causes PCD by Impairing Cilia Orientation and Mucociliary Clearance.	American Journal of Human Genetics	2019
30995496	O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3.	Immunity	2019
31311847	Application of a MYC degradation screen identifies sensitivity to CDK9 inhibitors in KRAS-mutant pancreatic cancer.	Science Signaling	2019
31497954	Data-Driven Construction of Antitumor Agents with Controlled Polypharmacology.	Journal of the American Chemical Society	2019
31530866	TBK1 Limits mTORC1 by Promoting Phosphorylation of Raptor Ser877.	Scientific Reports	2019
31189689	Therapeutic Effect of Y-27632 on Tumorigenesis and Cisplatin-Induced Peripheral Sensory Loss through RhoA-NF-ÎºB.	Molecular Cancer Research	2019
31145866	Pathway-Based High-Throughput Chemical Screen Identifies Compounds That Decouple Heterochromatin Transformations.	SLAS Discov	2019
31011191	Organ-specific metastases obtained by culturing colorectal cancer cells on tissue-specific decellularized scaffolds.	Nature Biomedical Engineering	2018
30543776	O-GlcNAc Transferase Links Glucose Metabolism to MAVS-Mediated Antiviral Innate Immunity.		2018