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Author Details

Bryan L Roth
UNC Chapel Hill School of Medicine
1980
509
117
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
38052317Illuminating the understudied GPCR-ome.Drug Discov Today2024
38052317Illuminating the understudied GPCR-ome.Drug Discov Today2024
36302898Ligand recognition and allosteric modulation of the human MRGPRX1 receptor.Nat Chem Biol2023
36302898Ligand recognition and allosteric modulation of the human MRGPRX1 receptor.Nat Chem Biol2023
36411392Insights into distinct signaling profiles of the µOR activated by diverse agonists.Nat Chem Biol2023
36450356Structure-based design of bitopic ligands for the µ-opioid receptor.Nature2023
37808655A suite of engineered mice for interrogating psychedelic drug actions.bioRxiv2023
37995655Molecular basis of opioid receptor signaling.Cell2023
37900918The G protein biased serotonin 5-HT2A receptor agonist lisuride exerts anti-depressant drug-like activities in mice.Front Mol Biosci2023
37977125CryoEM structures of adhesion in GPCR CD97: Filling in some of the gaps.Cell Chem Biol2023
37555591De Novo Design of κ-Opioid Receptor Antagonists Using a Generative Deep-Learning Framework.J Chem Inf Model2023
38057319Docking for EP4R antagonists active against inflammatory pain.Nat Commun2023
37961094Nonspecific membrane bilayer perturbations by ivermectin underlie SARS-CoV-2 <i>in vitro</i> activity.bioRxiv2023
37478823Built-in functional selectivity in neurons is mediated by the neuronal protein, GINIP.Mol Cell2023
36973264Structural insights into the human niacin receptor HCA2-G<sub>i</sub> signalling complex.Nat Commun2023
37333376The G protein biased serotonin 5-HT 2A receptor agonist lisuride exerts anti-depressant drug-like activities in mice.bioRxiv2023
36638794Structures of the entire human opioid receptor family.Cell2023
37067459G protein-coupled receptors as targets for transformative neuropsychiatric therapeutics.Am J Physiol Cell Physiol2023
37122272Psychedelics as Transformative Therapeutics.Am J Psychiatry2023
36608655SnapShot: Psychedelics and serotonin receptor signaling.Cell2023
37038975Structural insights into angiotensin receptor signaling modulation by balanced and biased agonists.EMBO J2023
37162828De Novo Design of κ-Opioid Receptor Antagonists Using a Generative Deep Learning Framework.bioRxiv2023
37808655A suite of engineered mice for interrogating psychedelic drug actions.bioRxiv2023
37961094Nonspecific membrane bilayer perturbations by ivermectin underlie SARS-CoV-2 <i>in vitro</i> activity.bioRxiv2023
37555591De Novo Design of κ-Opioid Receptor Antagonists Using a Generative Deep-Learning Framework.J Chem Inf Model2023
37900918The G protein biased serotonin 5-HT2A receptor agonist lisuride exerts anti-depressant drug-like activities in mice.Front Mol Biosci2023
37478823Built-in functional selectivity in neurons is mediated by the neuronal protein, GINIP.Mol Cell2023
37995655Molecular basis of opioid receptor signaling.Cell2023
38057319Docking for EP4R antagonists active against inflammatory pain.Nat Commun2023
37977125CryoEM structures of adhesion in GPCR CD97: Filling in some of the gaps.Cell Chem Biol2023
37122272Psychedelics as Transformative Therapeutics.Am J Psychiatry2023
37038975Structural insights into angiotensin receptor signaling modulation by balanced and biased agonists.EMBO J2023
36973264Structural insights into the human niacin receptor HCA2-G<sub>i</sub> signalling complex.Nat Commun2023
37333376The G protein biased serotonin 5-HT 2A receptor agonist lisuride exerts anti-depressant drug-like activities in mice.bioRxiv2023
37067459G protein-coupled receptors as targets for transformative neuropsychiatric therapeutics.Am J Physiol Cell Physiol2023
37162828De Novo Design of κ-Opioid Receptor Antagonists Using a Generative Deep Learning Framework.bioRxiv2023
36608655SnapShot: Psychedelics and serotonin receptor signaling.Cell2023
36638794Structures of the entire human opioid receptor family.Cell2023
36450356Structure-based design of bitopic ligands for the µ-opioid receptor.Nature2023
36411392Insights into distinct signaling profiles of the µOR activated by diverse agonists.Nat Chem Biol2023
34797943Molecular insights into psychedelic drug action.J Neurochem2022
35836068TRUPATH: An Open-Source Biosensor Platform for Interrogating the GPCR Transducerome.Methods Mol Biol2022
36171289Bespoke library docking for 5-HT<sub>2A</sub> receptor agonists with antidepressant activity.Nature2022
35835867Inactive and active state structures template selective tools for the human 5-HT<sub>5A</sub> receptor.Nat Struct Mol Biol2022
36087581Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD.Neuron2022
35931057Structural insights from G-protein-coupled receptor complexes enable the rational engineering of improved light-activated designer receptors.Structure2022
35403009Agonist and antagonist TRUPATH assays for G protein-coupled receptors.STAR Protoc2022
35977511Molecular insights into the regulation of constitutive activity by RNA editing of 5HT<sub>2C</sub> serotonin receptors.Cell Rep2022
35046097Subversion of Serotonin Receptor Signaling in Osteoblasts by Kynurenine Drives Acute Myeloid Leukemia.Cancer Discov2022
34797943Molecular insights into psychedelic drug action.J Neurochem2022
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Collaborators

Xi-Ping Huang
University of North Carolina School of Medicine
Co-authored papers 85
Vincent Setola
West Virginia University School of Medicine
Co-authored papers 48
Brian K Shoichet
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 35
Jian Jin
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Co-authored papers 25
Raymond C Stevens
iHuman Institute, ShanghaiTech University
Co-authored papers 22
Jeffrey F DiBerto
University of North Carolina at Chapel Hill
Co-authored papers 21
John J Irwin
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 13
Gye Won Han
Bridge Institute, University of Southern California
Co-authored papers 13
Brian E Krumm
University of North Carolina School of Medicine
Co-authored papers 12
David E Nichols
Eshelman School of Pharmacy, University of North Carolina
Co-authored papers 9
Kate L White
Lawrence Berkeley National Laboratory
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Cheryl H Arrowsmith
University of Toronto
Co-authored papers 8
Michael J Keiser
Institute for Neurodegenerative Diseases, University of California san francisco
Co-authored papers 7
Ryan H Gumpper
UNC School of Medicine
Co-authored papers 7
Sheng Wang
University of North Carolina at Chapel Hill School of Medicine
Co-authored papers 7
Alexander Tropsha
Co-authored papers 6
Georgios Skiniotis
Stanford University School of Medicine
Co-authored papers 5
Jiankun Lyu
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 5
Jonathan F Fay
University of North Carolina School of Medicine
Co-authored papers 5
Joel Karpiak
Department of Pharmaceutical Sciences, University of California San Francisco
Co-authored papers 5
Michael J Robertson
Stanford University School of Medicine
Co-authored papers 5
Kuglae Kim
University of North Carolina School of Medicine
Co-authored papers 5
Joseph A Carcillo
UPMC Children's Hospital of Pittsburgh, University of Pittsburgh
Co-authored papers 4
Stefan Knapp
Institute of Pharmaceutical Chemistry, Goethe University
Co-authored papers 4
Thomas A Munro
Deakin University
Co-authored papers 4
John P Overington
Institute of Cardiovascular Science, University College London
Co-authored papers 4
Alpay B Seven
Stanford University School of Medicine
Co-authored papers 4
Dalia Barsyte-Lovejoy
University of Toronto, College St
Co-authored papers 4
Ying-Xian Pan
Co-authored papers 4
Hualiang Jiang
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Co-authored papers 3
Release 1.2