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Author Details

Xiaojun Xu
China Pharmaceutical University
2012
64
24
PMIDPaper TitleJournal TitlePublished Year
36198833HSP90β promotes osteoclastogenesis by dual-activation of cholesterol synthesis and NF-κB signaling.Cell Death Differ2023
37279813Qing-Zhi-Tiao-Gan-Tang (QZTGT) prevents nonalcoholic steatohepatitis (NASH) by expression pattern correction.J Ethnopharmacol2023
37012254Farrerol directly activates the deubiqutinase UCHL3 to promote DNA repair and reprogramming when mediated by somatic cell nuclear transfer.Nat Commun2023
37236192Small-molecule MHC-II inducers promote immune detection and anti-cancer immunity via editing cancer metabolism.Cell Chem Biol2023
36969043<sup>18</sup>F-FDG PET/CT radiomics signature and clinical parameters predict progression-free survival in breast cancer patients: A preliminary study.Front Oncol2023
34898046Analysis of CDK12 alterations in a pan-cancer database.Cancer Med2022
36479116Development of Nectin4/FAP-targeted CAR-T cells secreting IL-7, CCL19, and IL-12 for malignant solid tumors.Front Immunol2022
35965586Combination of 4-1BB and DAP10 promotes proliferation and persistence of NKG2D(bbz) CAR-T cells.Front Oncol2022
359325307-aminocephalosporanic acid, a novel HSP90β inhibitor, attenuates HFD-induced hepatic steatosis.Biochem Biophys Res Commun2022
36035394High percentages of peripheral blood T-cell activation in childhood Hodgkin's lymphoma are associated with inferior outcome.Front Med (Lausanne)2022
32432943Discovery of a potent SCAP degrader that ameliorates HFD-induced obesity, hyperlipidemia and insulin resistance via an autophagy-independent lysosomal pathway.Autophagy2021
33542242SPT6 promotes epidermal differentiation and blockade of an intestinal-like phenotype through control of transcriptional elongation.Nat Commun2021
33860590Administration of isoliquiritigenin prevents nonalcoholic fatty liver disease through a novel IQGAP2-CREB-SIRT1 axis.Phytother Res2021
33657393The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity.Cell Metab2021
34566645Metabolomics Analysis Reveals Interaction of Base-Line Chemotherapy and Shiyiwei Shenqi Tablets in Breast Cancer Treatment.Front Pharmacol2021
34250403Synchronous, Yet Genomically Distinct, GIST Offer New Insights Into Precise Targeting of Tumor Driver Mutations.JCO Precis Oncol2021
34074054Ganoderic Acid A Promotes Amyloid-β Clearance (In Vitro) and Ameliorates Cognitive Deficiency in Alzheimer's Disease (Mouse Model) through Autophagy Induced by Activating Axl.Int J Mol Sci2021
33984804Design, synthesis, and biological evaluation of novel tetrahydroprotoberberine derivatives to reduce SREBPs expression for the treatment of hyperlipidemia.Eur J Med Chem2021
34292749Design, Synthesis, and Biological Evaluation of Organic Nitrite (NO<sub>2</sub><sup>-</sup>) Donors as Potential Anticerebral Ischemia Agents.J Med Chem2021
34312368C5aR1-positive neutrophils promote breast cancer glycolysis through WTAP-dependent m6A methylation of ENO1.Cell Death Dis2021
34285288Prevalence of cancer susceptibility variants in patients with multiple Lynch syndrome related cancers.Sci Rep2021
33165811Sodium cantharidinate, a novel anti-pancreatic cancer agent that activates functional p53.Sci China Life Sci2021
32509221Runx2 is required for activity of CD44<sup>+</sup>/CD24<sup>-/low</sup> breast cancer stem cell in breast cancer development.Am J Transl Res2020
31907393Dual targeting of SREBP2 and ERRα by carnosic acid suppresses RANKL-mediated osteoclastogenesis and prevents ovariectomy-induced bone loss.Cell Death Differ2020
33089974The SIRT6 activator MDL-800 improves genomic stability and pluripotency of old murine-derived iPS cells.Aging Cell2020
32574974Triptolide impairs genome integrity by directly blocking the enzymatic activity of DNA-PKcs in human cells.Biomed Pharmacother2020
32644042A high-throughput small molecule screen identifies farrerol as a potentiator of CRISPR/Cas9-mediated genome editing.Elife2020
32142794TEAD1 and TEAD3 Play Redundant Roles in the Regulation of Human Epidermal Proliferation.J Invest Dermatol2020
30537674Novel hepatoprotective role of Leonurine hydrochloride against experimental non-alcoholic steatohepatitis mediated via AMPK/SREBP1 signaling pathway.Biomed Pharmacother2019
35532512Correction: Praeruptorin B improves diet-induced hyperlipidemia and alleviates insulin resistance <i>via</i> regulating SREBP signaling pathway.RSC Adv2019
31586469Neohesperidin inhibits TGF-β1/Smad3 signaling and alleviates bleomycin-induced pulmonary fibrosis in mice.Eur J Pharmacol2019
31519929HNRNPK maintains epidermal progenitor function through transcription of proliferation genes and degrading differentiation promoting mRNAs.Nat Commun2019
31534518Inhibition of HSP90β Improves Lipid Disorders by Promoting Mature SREBPs Degradation via the Ubiquitin-proteasome System.Theranostics2019
30869786Evaluating and sharing global genetic ancestry in biomedical datasets.J Am Med Inform Assoc2019
30716311Phellodendrine chloride suppresses proliferation of KRAS mutated pancreatic cancer cells through inhibition of nutrients uptake via macropinocytosis.Eur J Pharmacol2019
30579258Administration of methyl palmitate prevents non-alcoholic steatohepatitis (NASH) by induction of PPAR-α.Biomed Pharmacother2019
30578886M2 macrophage-derived IL6 mediates resistance of breast cancer cells to hedgehog inhibition.Toxicol Appl Pharmacol2019
29027990IL6 blockade potentiates the anti-tumor effects of γ-secretase inhibitors in Notch3-expressing breast cancer.Cell Death Differ2018
30166101Carnosic acid improves diabetic nephropathy by activating Nrf2/ARE and inhibition of NF-κB pathway.Phytomedicine2018
30128052Jujuboside A promotes Aβ clearance and ameliorates cognitive deficiency in Alzheimer's disease through activating Axl/HSP90/PPARγ pathway.Theranostics2018
29546475Targeted delivery of antigen to intestinal dendritic cells induces oral tolerance and prevents autoimmune diabetes in NOD mice.Diabetologia2018
29792857TGF-β plays a vital role in triple-negative breast cancer (TNBC) drug-resistance through regulating stemness, EMT and apoptosis.Biochem Biophys Res Commun2018
29374148Downregulation of annexin A3 inhibits tumor metastasis and decreases drug resistance in breast cancer.Cell Death Dis2018
28736782pH-Responsive de-PEGylated nanoparticles based on triphenylphosphine-quercetin self-assemblies for mitochondria-targeted cancer therapy.Chem Commun (Camb)2017
28153734High-throughput screening for Survivin and Borealin interaction inhibitors in hepatocellular carcinoma.Biochem Biophys Res Commun2017
28501578Anhydroicaritin, a SREBPs inhibitor, inhibits RANKL-induced osteoclastic differentiation and improves diabetic osteoporosis in STZ-induced mice.Eur J Pharmacol2017
28994286Novel Derivative of Bardoxolone Methyl Improves Safety for the Treatment of Diabetic Nephropathy.J Med Chem2017
27025397A chemical family-based strategy for uncovering hidden bioactive molecules and multicomponent interactions in herbal medicines.Sci Rep2016
26432385Comparison of five Lonicera flowers by simultaneous determination of multi-components with single reference standard method and principal component analysis.J Pharm Biomed Anal2016
27816546Anhydroicaritin improves diet-induced obesity and hyperlipidemia and alleviates insulin resistance by suppressing SREBPs activation.Biochem Pharmacol2016
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Collaborators

University of California
Co-authored papers 4
University of California San Diego
Co-authored papers 3
Tsinghua University
Co-authored papers 1
Department of Medicine and Moores Cancer Center, University of California San Diego.
Co-authored papers 1
Co-authored papers 1
Moores Cancer Center, university of california san diego
Co-authored papers 1
university of california san diego Health System
Co-authored papers 1
Huaihe Hospital of Henan University
Co-authored papers 1
university of california san diego School of Medicine
Co-authored papers 1
University of Rochester
Co-authored papers 1
Co-authored papers 1
Co-authored papers 1
Co-authored papers 1
Co-authored papers 1
Escola de Administracao de Empresas - FGV, Stanford University, University of California San Diego, University of Sao Paulo, Yale School of Medicine
Co-authored papers 1
university of california san diego
Co-authored papers 1
University of California San Diego
Co-authored papers 1