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Author Details

Alfred Ayala
Brown University
1987
311
75
PMIDPaper TitleJournal TitlePublished Year
38035776VISTA nonredundantly regulates proliferation and CD69low γδ T cell accumulation in the intestine in murine sepsis.J Leukoc Biol2024
37305124Lymphocyte HVEM/BTLA co-expression after critical illness demonstrates severity indiscriminate upregulation, impacting critical illness-induced immunosuppression.Front Med (Lausanne)2023
37493576SPLENIC INVARIANT NATURAL KILLER T CELLS PLAY A SIGNIFICANT ROLE IN THE RESPONSE TO POLYMICROBIAL SEPSIS.Shock2023
37113606Application of single cell multiomics points to changes in chromatin accessibility near calcitonin receptor like receptor and a possible role for adrenomedullin in the post-shock lung.Front Med (Lausanne)2023
34907117Patho-Mechanisms for Hemorrhage/Sepsis-Induced Indirect Acute Respiratory Distress Syndrome: A Role for Lung TIE1 and Its Regulation by Neutrophils.Shock2022
35401514Negative Immune Checkpoint Protein, VISTA, Regulates the CD4<sup>+</sup> T<sub>reg</sub> Population During Sepsis Progression to Promote Acute Sepsis Recovery and Survival.Front Immunol2022
35860251The Neonatal Innate Immune Response to Sepsis: Checkpoint Proteins as Novel Mediators of This Response and as Possible Therapeutic/Diagnostic Levers.Front Immunol2022
36175355NLRP3 inflammasome activation in cigarette smoke priming for Pseudomonas aeruginosa-induced acute lung injury.Redox Biol2022
32996833Unmasking Unique Immune Altering Aspects of the Microbiome as a Tool to Correct Sepsis-Induced Immune Dysfunction.Surg Infect (Larchmt)2021
33641552Emerging therapeutic targets for sepsis.Expert Opin Ther Targets2021
33746973Survival and Pulmonary Injury After Neonatal Sepsis: PD1/PDL1's Contributions to Mouse and Human Immunopathology.Front Immunol2021
33065715A Peptide-Based Checkpoint Immunomodulator Alleviates Immune Dysfunction in Murine Polymicrobial Sepsis.Shock2021
31522034Herpes Virus Entry Mediator (HVEM): A Novel Potential Mediator of Trauma-Induced Immunosuppression.J Surg Res2020
31994912Blockade of endothelial, but not epithelial, cell expression of PD-L1 following severe shock attenuates the development of indirect acute lung injury in mice.Am J Physiol Lung Cell Mol Physiol2020
32077999Alternative RNA splicing and alternative transcription start/end in acute respiratory distress syndrome.Intensive Care Med2020
31914698Blockade of equilibrative nucleoside transporter 1/2 protects against Pseudomonas aeruginosa-induced acute lung injury and NLRP3 inflammasome activation.FASEB J2020
31733683Check Point Inhibitors and Their Role in Immunosuppression in Sepsis.Crit Care Clin2020
32957908SHP2 inhibitor PHPS1 ameliorates acute kidney injury by Erk1/2-STAT3 signaling in a combined murine hemorrhage followed by septic challenge model.Mol Med2020
32956213Peripheral vascular endothelial growth factor changes after transcranial magnetic stimulation in treatment-resistant depression.Neuroreport2020
32210956Novel Peptide-Based PD1 Immunomodulators Demonstrate Efficacy in Infectious Disease Vaccines and Therapeutics.Front Immunol2020
30431333A novel role for programmed cell death receptor ligand 2 in sepsis-induced hepatic dysfunction.Am J Physiol Gastrointest Liver Physiol2019
30106873Part II: Minimum Quality Threshold in Preclinical Sepsis Studies (MQTiPSS) for Types of Infections and Organ Dysfunction Endpoints.Shock2019
29877959Premise for Standardized Sepsis Models.Shock2019
30475329Hemorrhage Attenuates Neutrophil Recruitment in Response to Secondary Respiratory Infection by Pseudomonas Aeruginosa.Shock2019
30531604Herpes Virus Entry Mediator (HVEM) Expression Promotes Inflammation/ Organ Injury in Response to Experimental Indirect-Acute Lung Injury.Shock2019
29393983A novel role for coinhibitory receptors/checkpoint proteins in the immunopathology of sepsis.J Leukoc Biol2018
30106875Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): An International Expert Consensus Initiative for Improvement of Animal Modeling in Sepsis.Shock2018
30134817Changes in the process of alternative RNA splicing results in soluble B and T lymphocyte attenuator with biological and clinical implications in critical illness.Mol Med2018
30105433Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis.Infection2018
29935165Group 2 Innate Lymphoid Cells (ILC2s) Are Key Mediators of the Inflammatory Response in Polymicrobial Sepsis.Am J Pathol2018
30225655Correction to: Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis.Infection2018
30112605Minimum quality threshold in pre-clinical sepsis studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis.Intensive Care Med Exp2018
30619369Novel Role for PD-1:PD-L1 as Mediator of Pulmonary Vascular Endothelial Cell Functions in Pathogenesis of Indirect ARDS in Mice.Front Immunol2018
29374076PAD4 Deficiency Leads to Decreased Organ Dysfunction and Improved Survival in a Dual Insult Model of Hemorrhagic Shock and Sepsis.J Immunol2018
27405068Divergent Effects of Neutrophils on Fas-Induced Pulmonary Inflammation, Apoptosis, and Lung Damage.Shock2017
29209308Program Cell Death Receptor-1-Mediated Invariant Natural Killer T-Cell Control of Peritoneal Macrophage Modulates Survival in Neonatal Sepsis.Front Immunol2017
27796667Lymphocyte integrin expression differences between SIRS and sepsis patients.Ir J Med Sci2017
28012568Improved survival after induction of sepsis by cecal slurry in PD-1 knockout murine neonates.Surgery2017
27782294A Novel Role for Programmed Cell Death Receptor Ligand-1 (PD-L1) in Sepsis-Induced Intestinal Dysfunction.Mol Med2017
27864287Double-hit mouse model of cigarette smoke priming for acute lung injury.Am J Physiol Lung Cell Mol Physiol2017
27622642Cl-Amidine Prevents Histone 3 Citrullination and Neutrophil Extracellular Trap Formation, and Improves Survival in a Murine Sepsis Model.J Innate Immun2017
26717105Effect of PD-1: PD-L1 in Invariant Natural Killer T-Cell Emigration and Chemotaxis Following Sepsis.Shock2016
26674453Enhanced Innate Inflammation Induced by Anti-BTLA Antibody in Dual Insult Model of Hemorrhagic Shock/Sepsis.Shock2016
26529660BLOCKADE OF ENDOTHELIAL GROWTH FACTOR, ANGIOPOIETIN-2, REDUCES INDICES OF ARDS AND MORTALITY IN MICE RESULTING FROM THE DUAL-INSULTS OF HEMORRHAGIC SHOCK AND SEPSIS.Shock2016
27835962Soluble programmed cell death receptor-1 (sPD-1): a potential biomarker with anti-inflammatory properties in human and experimental acute respiratory distress syndrome (ARDS).J Transl Med2016
27288425Contribution of programmed cell death receptor (PD)-1 to Kupffer cell dysfunction in murine polymicrobial sepsis.Am J Physiol Gastrointest Liver Physiol2016
24391146TAT-SNAP-23 treatment inhibits the priming of neutrophil functions contributing to shock and/or sepsis-induced extra-pulmonary acute lung injury.Innate Immun2015
26417200Biomarkers for Sepsis: What Is and What Might Be?Biomark Insights2015
25850344Liver myeloid-derived suppressor cells expand in response to liver metastases in mice and inhibit the anti-tumor efficacy of anti-CEA CAR-T.Cancer Immunol Immunother2015
25761077Divergent invariant natural killer T-cell response to sepsis of abdominal vs. non-abdominal origin in human beings.Surg Infect (Larchmt)2015
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Collaborators

Rhode Island Hospital and The Alpert School of Medicine at Brown University
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Rhode Island Hospital and the Warren Alpert Medical School of Brown University
Co-authored papers 8
Emory University
Co-authored papers 7
Nationwide Children's Hospital
Co-authored papers 7
University of Florida Health
Co-authored papers 6
The William Harvey Research Institute, Queen Mary University of London
Co-authored papers 4
Ludwig-Boltzmann Institute for Experimental and Clinical Traumatology
Co-authored papers 4
St. Michael's Hospital
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Ludwig Boltzmann Institute for Experimental and Clinical Traumatology
Co-authored papers 4
AUVA Trauma Hospital Salzburg
Co-authored papers 4
University of Michigan ann arbor
Co-authored papers 3
Molecular Cardiology Research Institute, Tufts Medical Center
Co-authored papers 3
David Geffen School of Medicine, University of California Los Angeles
Co-authored papers 2
Uniformed Services University of the Health Sciences
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University of Florida College of Medicine
Co-authored papers 2
University of Florida, College of Medicine
Co-authored papers 2
David Geffen School of Medicine, University of California Los Angeles
Co-authored papers 2
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University of Florida College of Medicine
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University of Florida College of Medicine and Dentistry
Co-authored papers 1
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University of Occupational and Environmental Health
Co-authored papers 1
The University of Kansas Health System
Co-authored papers 1
University of Florida, Univerzitet u Sarajevu Medicinski Fakultet
Co-authored papers 1
Infectious Disease Division at Brown University Warren Alpert Medical School
Co-authored papers 1
Merck & Co. Inc.
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Memorial Sloan Kettering Cancer Center
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Kent County Hospital
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