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Author Details

Bradley T Hyman
Massachusetts General Hospital
1977
776
166
Timothy Clark (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37333251Machine learning of dissection photographs and surface scanning for quantitative 3D neuropathology.bioRxiv2024
37633260Toxic effects of mutant huntingtin in axons are mediated by its proline-rich domain.Brain2024
38000018Aberrant vascular architecture in the hippocampus correlates with tau burden in mild cognitive impairment and Alzheimer's disease.J Cereb Blood Flow Metab2024
37461318Distinct transcriptomic responses to Aβ plaques, neurofibrillary tangles, and APOE in Alzheimer's disease.Alzheimers Dement2024
36378913All the Tau We Cannot See.Annu Rev Med2023
37622323Potential impact of the COVID-19 pandemic on everyday preferences for persons with cognitive impairment.Int Psychogeriatr2023
37553663Specific detection of tau seeding activity in Alzheimer's disease using rationally designed biosensor cells.Mol Neurodegener2023
37547292<i>VWA3A</i>-derived ependyma promoter drives increased therapeutic protein secretion into the CSF.Mol Ther Nucleic Acids2023
37733036Reply: Soluble oligomers or insoluble fibrils?Acta Neuropathol2023
37645718APOE2 gene therapy reduces amyloid deposition, and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease.bioRxiv2023
37600228Apolipoprotein E isoform does not influence trans-synaptic spread of tau pathology in a mouse model.Brain Neurosci Adv2023
37324243Spatial characterization of tangle-bearing neurons and ghost tangles in the human inferior temporal gyrus with three-dimensional imaging.Brain Commun2023
36993332Distinct Transcriptomic Responses to Aβ plaques, Neurofibrillary Tangles, and <i>APOE</i> in Alzheimer's Disease.bioRxiv2023
37081484Size matters: the impact of nucleus size on results from spatial transcriptomics.J Transl Med2023
37341831Tau seeding and spreading in vivo is supported by both AD-derived fibrillar and oligomeric tau.Acta Neuropathol2023
37208174Endothelial Cells Are Heterogeneous in Different Brain Regions and Are Dramatically Altered in Alzheimer's Disease.J Neurosci2023
37138318The G51D SNCA mutation generates a slowly progressive α-synuclein strain in early-onset Parkinson's disease.Acta Neuropathol Commun2023
37333415Age-dependent increase in tau phosphorylation at serine 396 in Huntington's disease pre-frontal cortex.medRxiv2023
37034629Tau seeding and spreading in vivo is supported by both AD-derived fibrillar and oligomeric tau.bioRxiv2023
37292997Interneuron diversity in the human dorsal striatum.Res Sq2023
36656755Tissue libraries enable rapid determination of conditions that preserve antibody labeling in cleared mouse and human tissue.Elife2023
36513939Cyclic Multiplex Fluorescent Immunohistochemistry Protocol to Phenotype Glial Cells in Formalin-Fixed Paraffin-Embedded Human Brain Sections.Methods Mol Biol2023
36609056Projection of Care Partners' Preferences in the Proxy Assessments of Everyday Preferences for Persons With Cognitive Impairment.Am J Geriatr Psychiatry2023
36937522Plasma biomarkers for diagnosis of Alzheimer's disease and prediction of cognitive decline in individuals with mild cognitive impairment.Front Neurol2023
36732784Common mouse models of tauopathy reflect early but not late human disease.Mol Neurodegener2023
36824974Endothelial Cells are Heterogeneous in Different Brain Regions and are Dramatically Altered in Alzheimer's Disease.bioRxiv2023
36756365Rate of tau propagation is a heritable disease trait in genetically diverse mouse strains.iScience2023
36698453Neuropathology-Independent Association Between <i>APOE</i> Genotype and Cognitive Decline Rate in the Normal Aging-Early Alzheimer Continuum.Neurol Genet2023
33455605Predictors of the importance of everyday preferences for older adults with cognitive impairment.Int Psychogeriatr2022
35444284Somatic genomic changes in single Alzheimer's disease neurons.Nature2022
35350555Tau propagation is dependent on the genetic background of mouse strains.Brain Commun2022
35800899Plasma biomarkers for prognosis of cognitive decline in patients with mild cognitive impairment.Brain Commun2022
35734478Technical Performance Evaluation of Olink Proximity Extension Assay for Blood-Based Biomarker Discovery in Longitudinal Studies of Alzheimer's Disease.Front Neurol2022
35853847[<sup>11</sup>C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer's disease.Nat Commun2022
35720706Mapping the Spatial Distribution of Fibrillar Polymorphs in Human Brain Tissue.Front Neurosci2022
36601621Altered localization of nucleoporin 98 in primary tauopathies.Brain Commun2022
36496454Causal inference in medical records and complementary systems pharmacology for metformin drug repurposing towards dementia.Nat Commun2022
36040790Development and Evaluation of a Natural Language Processing Annotation Tool to Facilitate Phenotyping of Cognitive Status in Electronic Health Records: Diagnostic Study.J Med Internet Res2022
36192402Author Correction: [<sup>11</sup>C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer's disease.Nat Commun2022
36320053A correlation map of genome-wide DNA methylation patterns between paired human brain and buccal samples.Clin Epigenetics2022
35208255A Nuclear Magnetic Resonance Spectroscopy Method in Characterization of Blood Metabolomics for Alzheimer's Disease.Metabolites2022
35109872Cyclic multiplex fluorescent immunohistochemistry and machine learning reveal distinct states of astrocytes and microglia in normal aging and Alzheimer's disease.J Neuroinflammation2022
34957486APOE4 derived from astrocytes leads to blood-brain barrier impairment.Brain2022
34757590Targeting Tau Mitigates Mitochondrial Fragmentation and Oxidative Stress in Amyotrophic Lateral Sclerosis.Mol Neurobiol2022
34581500Current directions in tau research: Highlights from Tau 2020.Alzheimers Dement2022
34779076Novel genetic variants in MAPT and alterations in tau phosphorylation in amyotrophic lateral sclerosis post-mortem motor cortex and cerebrospinal fluid.Brain Pathol2022
34801383Longitudinal Changes in Neuropsychiatric Symptoms: Impact of Discrepancy in Everyday Preferences Between Persons With Cognitive Impairment and Their Care Partners.Am J Geriatr Psychiatry2022
34297416Systematic review of human post-mortem immunohistochemical studies and bioinformatics analyses unveil the complexity of astrocyte reaction in Alzheimer's disease.Neuropathol Appl Neurobiol2022
33347974Systematic review and meta-analysis of human transcriptomics reveals neuroinflammation, deficient energy metabolism, and proteostasis failure across neurodegeneration.Neurobiol Dis2021
36199750Effect of <i>APOE</i> alleles on the glial transcriptome in normal aging and Alzheimer's disease.Nat Aging2021
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Collaborators

Matthew P Frosch
Massachusetts General Hospital and Harvard Medical School
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Rudolph E Tanzi
Co-authored papers 49
Martin Ingelsson
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Rebecca A Betensky
New York University.
Co-authored papers 31
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Co-authored papers 28
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Co-authored papers 25
George A Carlson
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Co-authored papers 22
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Co-authored papers 22
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University of California San Diego
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Dennis W Dickson
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David M Holtzman
Co-authored papers 15
Lindsay A Farrer
Boston University Chobanian & Avedisian School of Medicine
Co-authored papers 14
Jean-Paul G Vonsattel
Co-authored papers 14
Ole A Andreassen
Oslo University Hospital & Institute of Clinical Medicine, University of Oslo
Co-authored papers 13
E. Tessa Hedley-Whyte
Massachusetts General Hospital, Harvard Medical School
Co-authored papers 13
Juan C Troncoso
Co-authored papers 13
Lars Lannfelt
Co-authored papers 13
David A Bennett
Rush University Medical Center
Co-authored papers 13
Release 1.2