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Author Details

Franco J Vizeacoumar
College of Medicine, University of Saskatchewan
2002
62
25
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36761420Synthetic lethal interactions of DEAD/H-box helicases as targets for cancer therapy.Front Oncol2023
37820398Survey of NF1 inactivation by surrogate immunohistochemistry in ovarian carcinomas.Gynecol Oncol2023
37392382Integration of cancer-related genetic landscape of Eph receptors and ephrins with proteomics identifies a crosstalk between EPHB6 and EGFR.Cell Rep2023
36976175A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.Clin Cancer Res2023
37376581Generation of a SARS-CoV-2 Reverse Genetics System and Novel Human Lung Cell Lines That Exhibit High Virus-Induced Cytopathology.Viruses2023
36587138A CRISPR Platform for Targeted In Vivo Screens.Methods Mol Biol2023
35184384Differential expression of HNF1A and HNF1A-AS1 in colon cancer cells.IUBMB Life2022
35613581DDX41 is required for cGAS-STING activation against DNA virus infection.Cell Rep2022
36123435Homoharringtonine demonstrates a cytotoxic effect against triple-negative breast cancer cell lines and acts synergistically with paclitaxel.Sci Rep2022
35883689A Drug Repurposing Screen Identifies Fludarabine Phosphate as a Potential Therapeutic Agent for N-MYC Overexpressing Neuroendocrine Prostate Cancers.Cells2022
36077749Activation of the Anaphase Promoting Complex Reverses Multiple Drug Resistant Cancer in a Canine Model of Multiple Drug Resistant Lymphoma.Cancers (Basel)2022
33330905APOBEC1 cytosine deaminase activity on single-stranded DNA is suppressed by replication protein A.Nucleic Acids Res2021
33828156Mining the plasma-proteome associated genes in patients with gastro-esophageal cancers for biomarker discovery.Sci Rep2021
34590285Computational Prediction of Chemical Tools for Identification and Validation of Synthetic Lethal Interaction Networks.Methods Mol Biol2021
34452919Genome-wide synthetic lethal screen unveils novel CAIX-NFS1/xCT axis as a targetable vulnerability in hypoxic solid tumors.Sci Adv2021
34832669Highly Specific Sigma Receptor Ligands Exhibit Anti-Viral Properties in SARS-CoV-2 Infected Cells.Pathogens2021
34233649Identification of novel genes involved in apoptosis of HIV-infected macrophages using unbiased genome-wide screening.BMC Infect Dis2021
33430292Protein Tyrosine Kinases: Their Roles and Their Targeting in Leukemia.Cancers (Basel)2021
33066048The CINs of Polo-Like Kinase 1 in Cancer.Cancers (Basel)2020
30616753A Road Map to Personalizing Targeted Cancer Therapies Using Synthetic Lethality.Trends Cancer2019
31416843Banding Together: A Systematic Comparison of The Cancer Genome Atlas and the Mitelman Databases.Cancer Res2019
31351478Humanized yeast genetic interaction mapping predicts synthetic lethal interactions of FBXW7 in breast cancer.BMC Med Genomics2019
30817936Targeting the CINful genome: Strategies to overcome tumor heterogeneity.Prog Biophys Mol Biol2019
30548174Molecular characterization of an MLL1 fusion and its role in chromosomal instability.Mol Oncol2019
30651078Estrogen receptor signaling regulates the expression of the breast tumor kinase in breast cancer cells.BMC Cancer2019
29150435Biochemical characterization of INTS3 and C9ORF80, two subunits of hNABP1/2 heterotrimeric complex in nucleic acid binding.Biochem J2018
30140170Global phosphoproteomic analysis identifies SRMS-regulated secondary signaling intermediates.Proteome Sci2018
30374409Expression-based analyses indicate a central role for hypoxia in driving tumor plasticity through microenvironment remodeling and chromosomal instability.NPJ Syst Biol Appl2018
29700392EPHB6 augments both development and drug sensitivity of triple-negative breast cancer tumours.Oncogene2018
28583138Molecular characterization of breast cancer cell lines through multiple omic approaches.Breast Cancer Res2017
28432350Enhancing the throughput and multiplexing capabilities of next generation sequencing for efficient implementation of pooled shRNA and CRISPR screens.Sci Rep2017
29196508An integrated computational and experimental study uncovers FUT9 as a metabolic driver of colorectal cancer.Mol Syst Biol2017
29116180The EphB6 receptor is overexpressed in pediatric T cell acute lymphoblastic leukemia and increases its sensitivity to doxorubicin treatment.Sci Rep2017
29348886FRK inhibits breast cancer cell migration and invasion by suppressing epithelial-mesenchymal transition.Oncotarget2017
26810754Epigenetic silencing of CREB3L1 by DNA methylation is associated with high-grade metastatic breast cancers with poor prognosis and is prevalent in triple negative breast cancers.Breast Cancer Res2016
27788485The intrinsically kinase-inactive EPHB6 receptor predisposes cancer cells to DR5-induced apoptosis by promoting mitochondrial fragmentation.Oncotarget2016
27557495Therapeutic relevance of the protein phosphatase 2A in cancer.Oncotarget2016
27418135Targeting synthetic lethality between the SRC kinase and the EPHB6 receptor may benefit cancer treatment.Oncotarget2016
25963654Spindle Checkpoint Factors Bub1 and Bub2 Promote DNA Double-Strand Break Repair by Nonhomologous End Joining.Mol Cell Biol2015
26290498A High Through-put Platform for Recombinant Antibodies to Folded Proteins.Mol Cell Proteomics2015
25446836Building high-resolution synthetic lethal networks: a 'Google map' of the cancer cell.Trends Mol Med2014
24104479A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities.Mol Syst Biol2013
22009677PhenoM: a database of morphological phenotypes caused by mutation of essential genes in Saccharomyces cerevisiae.Nucleic Acids Res2012
22940862Interaction landscape of membrane-protein complexes in Saccharomyces cerevisiae.Nature2012
23021432Genome-wide analysis of intracellular pH reveals quantitative control of cell division rate by pH(c) in Saccharomyces cerevisiae.Genome Biol2012
22908312Hsp110 is required for spindle length control.J Cell Biol2012
22585861Essential gene profiles in breast, pancreatic, and ovarian cancer cells.Cancer Discov2012
21441928Systematic exploration of essential yeast gene function with temperature-sensitive mutants.Nat Biotechnol2011
20065090Integrating high-throughput genetic interaction mapping and high-content screening to explore yeast spindle morphogenesis.J Cell Biol2010
21081923Genetic interactions reveal the evolutionary trajectories of duplicate genes.Mol Syst Biol2010
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Collaborators

Frederick S Vizeacoumar
College of Medicine, University of Saskatchewan
Co-authored papers 38
Andrew Freywald
College of Medicine, University of Saskatchewan
Co-authored papers 25
Charles Boone
University of Toronto
Co-authored papers 10
Brenda J Andrews
University of Toronto
Co-authored papers 9
Tanya Freywald
University of Saskatchewan
Co-authored papers 7
Zhaolei Zhang
University of Toronto
Co-authored papers 6
Zhijian Li
University of Toronto
Co-authored papers 6
John D Aitchison
Center for Global Infectious Disease Research, Seattle Children's Research Institute
Co-authored papers 6
Richard A Rachubinski
University of Alberta
Co-authored papers 6
Alessandro Datti
University of Perugia
Co-authored papers 5
Ke Jin
West China Hospital, Sichuan University
Co-authored papers 4
Mohan Babu
University of Regina
Co-authored papers 4
Chad L Myers
University of Minnesota - Twin Cities
Co-authored papers 4
Michael Costanzo
Co-authored papers 4
Sondra Bahr
University of Toronto, College Street
Co-authored papers 3
Renqiang Min
Co-authored papers 3
Andrew Emili
Boston University School of Medicine, Boston University
Co-authored papers 3
Anne-Claude Gingras
Lunenfeld-Tanenbaum Research Institute
Co-authored papers 3
Jason Moffat
University of Toronto
Co-authored papers 3
Brian Raught
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 3
Marcello Marelli
AstraZeneca Oncology R&D
Co-authored papers 2
Xiaofeng Xin
Massachusetts Institute of Technology
Co-authored papers 2
Guoqing Zhong
University of Toronto
Co-authored papers 2
Jack F Greenblatt
College Street, University of Toronto
Co-authored papers 2
Eytan Ruppin
National Cancer Institute
Co-authored papers 2
Kerry Bloom
University of North Carolina at Chapel Hill
Co-authored papers 2
Jennifer J Smith
Institute for Systems Biology
Co-authored papers 2
Kevin R Brown
College Street, University of Toronto
Co-authored papers 2
James Vlasblom
University of Regina
Co-authored papers 2
Jeffrey L Wrana
Lunenfeld-Tanenbaum Research Institute Mount Sinai Hospital
Co-authored papers 2
Release 1.2