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Author Details

Dimpy Koul
The University of Texas MD Anderson Cancer Center
1996
54
31
PMIDPaper TitleJournal TitlePublished Year
35474131EGFR suppresses p53 function by promoting p53 binding to DNA-PKcs: a noncanonical regulatory axis between EGFR and wild-type p53 in glioblastoma.Neuro Oncol2022
33420056Integrated analysis of telomerase enzymatic activity unravels an association with cancer stemness and proliferation.Nat Commun2021
33738447The promise of DNA damage response inhibitors for the treatment of glioblastoma.Neurooncol Adv2021
33433610PARP-mediated PARylation of MGMT is critical to promote repair of temozolomide-induced O6-methylguanine DNA damage in glioblastoma.Neuro Oncol2021
31852834<i>EGFR</i> Amplification Induces Increased DNA Damage Response and Renders Selective Sensitivity to Talazoparib (PARP Inhibitor) in Glioblastoma.Clin Cancer Res2020
31497354Wild-type <i>TP53</i> defined gamma-secretase inhibitor sensitivity and synergistic activity with doxorubicin in GSCs.Am J Cancer Res2019
31815044BRCA1 identified as a modulator of temozolomide resistance in P53 wild-type GBM using a high-throughput shRNA-based synthetic lethality screening.Am J Cancer Res2019
31416846Tie2-FGFR1 Interaction Induces Adaptive PI3K Inhibitor Resistance by Upregulating Aurora A/PLK1/CDK1 Signaling in Glioblastoma.Cancer Res2019
29016926Activation of WEE1 confers resistance to PI3K inhibition in glioblastoma.Neuro Oncol2018
28903341APOBEC3G acts as a therapeutic target in mesenchymal gliomas by sensitizing cells to radiation-induced cell death.Oncotarget2017
28423515Preclinical therapeutic efficacy of a novel blood-brain barrier-penetrant dual PI3K/mTOR inhibitor with preferential response in PI3K/PTEN mutant glioma.Oncotarget2017
29073105PAF promotes stemness and radioresistance of glioma stem cells.Proc Natl Acad Sci U S A2017
27196759MSK1-Mediated β-Catenin Phosphorylation Confers Resistance to PI3K/mTOR Inhibitors in Glioblastoma.Mol Cancer Ther2016
24038660A high Notch pathway activation predicts response to γ secretase inhibitors in proneural subtype of glioma tumor-initiating cells.Stem Cells2014
25398854Retraction: Novel HSP90 inhibitor NVP-HSP990 targets cell-cycle regulators to ablate Olig 2-positive glioma tumor-initiating cells.Cancer Res2014
23492364Novel HSP90 inhibitor NVP-HSP990 targets cell-cycle regulators to ablate Olig2-positive glioma tumor-initiating cells.Cancer Res2013
23796897A survey of intragenic breakpoints in glioblastoma identifies a distinct subset associated with poor survival.Genes Dev2013
23502430Identification of prognostic gene signatures of glioblastoma: a study based on TCGA data analysis.Neuro Oncol2013
22065080Antitumor activity of NVP-BKM120--a selective pan class I PI3 kinase inhibitor showed differential forms of cell death based on p53 status of glioma cells.Clin Cancer Res2012
20473884Combined action of the dinuclear platinum compound BBR3610 with the PI3-K inhibitor PX-866 in glioblastoma.Int J Cancer2011
24048786Induction of MUC5AC mucin by conjugated bile acids in the esophagus involves the phosphatidylinositol 3-kinase/protein kinase C/activator protein-1 pathway.Cancer2011
21907928An integrated in vitro and in vivo high-throughput screen identifies treatment leads for ependymoma.Cancer Cell2011
21653596Establishment and characterization of clinically relevant models of ependymoma: a true challenge for targeted therapy.Neuro Oncol2011
21430111Identification of novel synergistic targets for rational drug combinations with PI3 kinase inhibitors using siRNA synthetic lethality screening against GBM.Neuro Oncol2011
20156803Cellular and in vivo activity of a novel PI3K inhibitor, PX-866, against human glioblastoma.Neuro Oncol2010
19671762NVP-BEZ235, a novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor, elicits multifaceted antitumor activities in human gliomas.Mol Cancer Ther2009
18381937Tissue transglutaminase regulates focal adhesion kinase/AKT activation by modulating PTEN expression in pancreatic cancer cells.Clin Cancer Res2008
19115005Exploratory analysis of the copy number alterations in glioblastoma multiforme.PLoS One2008
18836294PTEN signaling pathways in glioblastoma.Cancer Biol Ther2008
17235455PTEN down regulates AP-1 and targets c-fos in human glioma cells via PI3-kinase/Akt pathway.Mol Cell Biochem2007
16546978Inhibition of Akt survival pathway by a small-molecule inhibitor in human glioblastoma.Mol Cancer Ther2006
17011514PTEN enhances TNF-induced apoptosis through modulation of nuclear factor-kappaB signaling pathway in human glioma cells.Biochem Biophys Res Commun2006
15753362Integrated array-comparative genomic hybridization and expression array profiles identify clinically relevant molecular subtypes of glioblastoma.Cancer Res2005
16168115Se-methylselenocysteine inhibits phosphatidylinositol 3-kinase activity of mouse mammary epithelial tumor cells in vitro.Breast Cancer Res2005
16275989Targeting integrin-linked kinase inhibits Akt signaling pathways and decreases tumor progression of human glioblastoma.Mol Cancer Ther2005
14719118Differential activation of the Fas/CD95 pathway by Ad-p53 in human gliomas.Int J Oncol2004
15585642Prognostic significance of tissue transglutaminase in drug resistant and metastatic breast cancer.Clin Cancer Res2004
15265936Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates TNF-induced NF-kappa B activation through inhibition of activation of I kappa B alpha kinase and Akt in human non-small cell lung carcinoma: correlation with suppression of COX-2 synthesis.J Immunol2004
15492257Up-regulation of Flotillin-2 is associated with melanoma progression and modulates expression of the thrombin receptor protease activated receptor 1.Cancer Res2004
12869565Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKT cascades.J Biol Chem2003
11906179Promoter analysis of tumor suppressor gene PTEN: identification of minimum promoter region.Biochem Biophys Res Commun2002
12168088MMAC/PTEN tumor suppressor gene regulates vascular endothelial growth factor-mediated angiogenesis in prostate cancer.Int J Oncol2002
11948419Motif analysis of the tumor suppressor gene MMAC/PTEN identifies tyrosines critical for tumor suppression and lipid phosphatase activity.Oncogene2002
11559537Transfer of E2F-1 to human glioma cells results in transcriptional up-regulation of Bcl-2.Cancer Res2001
11278366Tumor suppressor MMAC/PTEN inhibits cytokine-induced NFkappaB activation without interfering with the IkappaB degradation pathway.J Biol Chem2001
11709701Suppression of matrix metalloproteinase-2 gene expression and invasion in human glioma cells by MMAC/PTEN.Oncogene2001
11103942MMAC1/PTEN inhibits cell growth and induces chemosensitivity to doxorubicin in human bladder cancer cells.Oncogene2000
9885980Functional and molecular analyses of 10q deletions in human gliomas.Genes Chromosomes Cancer1999
10363971Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/PTEN.Cancer Res1999
10213484Differential expression of MMAC/PTEN in glioblastoma multiforme: relationship to localization and prognosis.Cancer Res1999
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Collaborators

Wai-Kwan Alfred Yung
University of Texas M.D. Anderson Cancer Center
Co-authored papers 42
Siyuan Zheng
Greehey Children's Cancer Research Institute
Co-authored papers 9
Gordon B Mills
Knight Cancer Institute, Oregon Health and Sciences University
Co-authored papers 8
Erik P Sulman
NYU Grossman School of Medicine
Co-authored papers 8
Yiling Lu
Co-authored papers 6
Roel G W Verhaak
Yale School of Medicine
Co-authored papers 5
Michael A Davies
The University of Texas MD Anderson Cancer Center
Co-authored papers 5
John F de Groot
Co-authored papers 5
Yong-Wan Kim
Inje University Haeundae Paik Hospital
Co-authored papers 5
Howard Colman
Huntsman Cancer Institute, University of Utah
Co-authored papers 5
Kenneth Aldape
National Cancer Institute
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Jun Yao
The University of Texas MD Anderson Cancer Center
Co-authored papers 4
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The University of Texas M.D. Anderson Cancer Center
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Co-authored papers 3
Garth Powis
PHusis Therapeutics Inc.
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W K Alfred Yung
The University of Texas MD Anderson Cancer Center
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Lynda Chin
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Jonas S Almeida
National Cancer Institute (NCI)
Co-authored papers 2
Pablo R Freire
Baylor College of Medicine
Co-authored papers 2
Oliver B??gler
American Association for Cancer Research, Henry Ford Hospital, Ludwig Institute for Cancer Research, National Cancer Institute, Salk Institute for Biological Studies, University of Cambridge, University of Texas MD Anderson Cancer Center, Virginia Commonwealth University
Co-authored papers 2
Christopher A Bristow
The University of Texas MD Anderson Cancer Center
Co-authored papers 2
Ken Chen
University of Texas MD Anderson Cancer Center
Co-authored papers 1
Herbert Barton Grossman
University of Texas MD Anderson Cancer Center
Co-authored papers 1
YeoHyeon Hwang
University of Texas MD Anderson Cancer Center
Co-authored papers 1
Timothy P Heffernan
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David J McConkey
Johns Hopkins School of Medicine
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Yaoqi Alan Wang
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Robert E Dejournett
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Release 1.2