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Author Details

Jeffrey A Toretsky
Georgetown University Medical Center, Georgetown University
1986
125
47
Nathan Sheffield (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37732905Piperacetazine Directly Binds to the PAX3::FOXO1 Fusion Protein and Inhibits Its Transcriptional Activity.Cancer Res Commun2023
37732905Piperacetazine Directly Binds to the PAX3::FOXO1 Fusion Protein and Inhibits Its Transcriptional Activity.Cancer Res Commun2023
35047826Comprehensive profiling of mRNA splicing indicates that GC content signals altered cassette exon inclusion in Ewing sarcoma.NAR Cancer2022
35486030Coupling Lipid Labeling and Click Chemistry Enables Isolation of Extracellular Vesicles for Noninvasive Detection of Oncogenic Gene Alterations.Adv Sci (Weinh)2022
36417526Widespread hypertranscription in aggressive human cancers.Sci Adv2022
36115869An international working group consensus report for the prioritization of molecular biomarkers for Ewing sarcoma.NPJ Precis Oncol2022
35047826Comprehensive profiling of mRNA splicing indicates that GC content signals altered cassette exon inclusion in Ewing sarcoma.NAR Cancer2022
35486030Coupling Lipid Labeling and Click Chemistry Enables Isolation of Extracellular Vesicles for Noninvasive Detection of Oncogenic Gene Alterations.Adv Sci (Weinh)2022
36417526Widespread hypertranscription in aggressive human cancers.Sci Adv2022
36115869An international working group consensus report for the prioritization of molecular biomarkers for Ewing sarcoma.NPJ Precis Oncol2022
34304571<i>O</i>-Linked-<i>N</i>-Acetylglucosaminylation of the RNA-Binding Protein EWS N-Terminal Low Complexity Region Reduces Phase Separation and Enhances Condensate Dynamics.J Am Chem Soc2021
37168767The Use of Hyperbaric Oxygen Therapy in the Management of Severe Radiation-Induced Hemorrhagic Gastritis in a Pediatric Patient.JPGN Rep2021
33751768Afebrile S. aureus bacteremia in two patients with hemophagocytic lymphohistiocytosis receiving emapalumab/dexamethasone/etoposide.Pediatr Blood Cancer2021
33941613Targeting DDX3X Triggers Antitumor Immunity via a dsRNA-Mediated Tumor-Intrinsic Type I Interferon Response.Cancer Res2021
34304571<i>O</i>-Linked-<i>N</i>-Acetylglucosaminylation of the RNA-Binding Protein EWS N-Terminal Low Complexity Region Reduces Phase Separation and Enhances Condensate Dynamics.J Am Chem Soc2021
34133426Clofarabine induces ERK/MSK/CREB activation through inhibiting CD99 on Ewing sarcoma cells.PLoS One2021
33919988Ewing Sarcoma-Diagnosis, Treatment, Clinical Challenges and Future Perspectives.J Clin Med2021
37168767The Use of Hyperbaric Oxygen Therapy in the Management of Severe Radiation-Induced Hemorrhagic Gastritis in a Pediatric Patient.JPGN Rep2021
33919988Ewing Sarcoma-Diagnosis, Treatment, Clinical Challenges and Future Perspectives.J Clin Med2021
33751768Afebrile S. aureus bacteremia in two patients with hemophagocytic lymphohistiocytosis receiving emapalumab/dexamethasone/etoposide.Pediatr Blood Cancer2021
34133426Clofarabine induces ERK/MSK/CREB activation through inhibiting CD99 on Ewing sarcoma cells.PLoS One2021
33941613Targeting DDX3X Triggers Antitumor Immunity via a dsRNA-Mediated Tumor-Intrinsic Type I Interferon Response.Cancer Res2021
32815894Rapid and Complete Response to Combination Anti-CTLA-4 and Anti-PD-1 Checkpoint Inhibitor Therapy in a Patient With Stage IV Refractory End-stage Epithelioid Sarcoma: A Case Report.J Immunother2020
32016454Development of an Ewing sarcoma cell line with resistance to EWSâ¿¿FLI1 inhibitor YKâ¿¿4â¿¿279.Mol Med Rep2020
34220409Coupling Nanostructured Microchips with Covalent Chemistry Enables Purification of Sarcoma-Derived Extracellular Vesicles for Downstream Functional Studies.Adv Funct Mater2020
32815894Rapid and Complete Response to Combination Anti-CTLA-4 and Anti-PD-1 Checkpoint Inhibitor Therapy in a Patient With Stage IV Refractory End-stage Epithelioid Sarcoma: A Case Report.J Immunother2020
32680570A novel PARD3B-NUTM1 fusion in an aggressive primary CNS embryonal tumor in a young adult.Acta Neuropathol Commun2020
34220409Coupling Nanostructured Microchips with Covalent Chemistry Enables Purification of Sarcoma-Derived Extracellular Vesicles for Downstream Functional Studies.Adv Funct Mater2020
32016454Development of an Ewing sarcoma cell line with resistance to EWSâ¿¿FLI1 inhibitor YKâ¿¿4â¿¿279.Mol Med Rep2020
32680570A novel PARD3B-NUTM1 fusion in an aggressive primary CNS embryonal tumor in a young adult.Acta Neuropathol Commun2020
31025088Targeted inhibition of histone deacetylase leads to suppression of Ewing sarcoma tumor growth through an unappreciated EWS-FLI1/HDAC3/HSP90 signaling axis.J Mol Med (Berl)2019
31182435The ETS Inhibitors YK-4-279 and TK-216 Are Novel Antilymphoma Agents.Clin Cancer Res2019
31025088Targeted inhibition of histone deacetylase leads to suppression of Ewing sarcoma tumor growth through an unappreciated EWS-FLI1/HDAC3/HSP90 signaling axis.J Mol Med (Berl)2019
31392992EWS-FLI1 modulated alternative splicing of ARID1A reveals novel oncogenic function through the BAF complex.Nucleic Acids Res2019
31182435The ETS Inhibitors YK-4-279 and TK-216 Are Novel Antilymphoma Agents.Clin Cancer Res2019
31392992EWS-FLI1 modulated alternative splicing of ARID1A reveals novel oncogenic function through the BAF complex.Nucleic Acids Res2019
29655986Targeting Intrinsically Disordered Transcription Factors: Changing the Paradigm.J Mol Biol2018
30123424Identifying the druggable interactome of EWS-FLI1 reveals MCL-1 dependent differential sensitivities of Ewing sarcoma cells to apoptosis inducers.Oncotarget2018
30166462Rearrangement bursts generate canonical gene fusions in bone and soft tissue tumors.Science2018
29950716Author Correction: EWS-FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma.Nature2018
29382926Clofarabine inhibits Ewing sarcoma growth through a novel molecular mechanism involving direct binding to CD99.Oncogene2018
29655986Targeting Intrinsically Disordered Transcription Factors: Changing the Paradigm.J Mol Biol2018
29513652EWS-FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma.Nature2018
29778411A probable primary malignant bone tumor in a pre-Columbian human humerus from Cerro Brujo, Bocas del Toro, Panamá.Int J Paleopathol2018
30166462Rearrangement bursts generate canonical gene fusions in bone and soft tissue tumors.Science2018
30123424Identifying the druggable interactome of EWS-FLI1 reveals MCL-1 dependent differential sensitivities of Ewing sarcoma cells to apoptosis inducers.Oncotarget2018
29950716Author Correction: EWS-FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma.Nature2018
29778411A probable primary malignant bone tumor in a pre-Columbian human humerus from Cerro Brujo, Bocas del Toro, Panamá.Int J Paleopathol2018
29382926Clofarabine inhibits Ewing sarcoma growth through a novel molecular mechanism involving direct binding to CD99.Oncogene2018
29513652EWS-FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma.Nature2018
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Collaborators

Aykut Uren
Georgetown University Medical Center
Co-authored papers 45
Hayriye V Erkizan
Co-authored papers 16
Garrett T Graham
Co-authored papers 13
Lee J Helman
Osteosarcoma Institute
Co-authored papers 11
Heinrich Kovar
St. Anna Children's Cancer Research Institute (CCRI), Medical University Vienna
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Seattle Children's Research Institute
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Illumina Inc.
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Dana-Farber Cancer Institute
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Stephen L Lessnick
The Ohio State University College of Medicine
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Memorial Sloan Kettering Cancer Center
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University Hospital Essen, West German Cancer Center
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Servicio de Anatomia Patologica. Hospital Universitario Virgen del Rocio.
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Donald A Barkauskas
Keck School of Medicine of the University of Southern California
Co-authored papers 4
Richard Moriggl
Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna
Co-authored papers 4
Franck Tirode
Cancer Center of Lyon
Co-authored papers 4
Markus Metzler
University Hospital Erlangen
Co-authored papers 4
Olivier Delattre
PSL Research University, Institut Curie Research Center, INSERM U, Institut Curie
Co-authored papers 4
Chand Khanna
National Cancer Institute, National Institutes of Health
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Katia Scotlandi
IRCCS Istituto Ortopedico Rizzoli
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Brent T Harris
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Thomas G P Gr??newald
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Release 1.2