Author details

Full Name

Wanda K O'Neal

Affiliation

ORCID

Career Start Year

1993

Papers

157

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37351609	Systemic Markers of Lung Function and Forced Expiratory Volume in 1 Second Decline across Diverse Cohorts.	Ann Am Thorac Soc	2023
36343688	Clinical Implications of Low Absolute Blood Eosinophil Count in the SPIROMICS COPD Cohort.	Chest	2023
36342131	Prolonged, physiologically relevant nicotine concentrations in the airways of smokers.	American Journal of Physiology - Lung Cellular and Molecular Physiology	2023
38016030	Proximal and Distal Bronchioles Contribute to the Pathogenesis of Non-Cystic Fibrosis Bronchiectasis (NCFB).		2023
37286633	Large scale proteomic studies create novel privacy considerations.	Sci Rep	2023
37286295	Blood Gene Expression and Immune Cell Subtypes Associated with Chronic Obstructive Pulmonary Disease Exacerbations.	Am J Respir Crit Care Med	2023
37217548	A blood and bronchoalveolar lavage protein signature of rapid FEV<sub>1</sub> decline in smoking-associated COPD.	Sci Rep	2023
37285404	Chronic airway epithelial hypoxia exacerbates injury in muco-obstructive lung disease through mucus hyperconcentration.		2023
37030524	Reduced quantity and function of pneumococcal antibodies are associated with exacerbations of COPD in SPIROMICS.	Clin Immunol	2023
37199731	Impact of Bronchiectasis on COPD Severity and Alpha-1 Antitrypsin Deficiency as a Risk Factor in Individuals with a Heavy Smoking History.		2023
36921087	Genetic Modifiers of Cystic Fibrosis Lung Disease Severity: Whole-Genome Analysis of 7,840 Patients.	Am J Respir Crit Care Med	2023
35128485	Leveraging TOPMed imputation server and constructing a cohort-specific imputation reference panel to enhance genotype imputation among cystic fibrosis patients.	HGG Adv	2022
35816430	Prevalence and Mechanisms of Mucus Accumulation in COVID-19 Lung Disease.	Am J Respir Crit Care Med	2022
35879412	Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection.	Nat Genet	2022
35629872	A Metabolomic Severity Score for Airflow Obstruction and Emphysema.	Metabolites	2022
35363522	Mucus concentration-dependent biophysical abnormalities unify submucosal gland and superficial airway dysfunction in cystic fibrosis.	Science advances	2022
35857635	SARS-CoV-2 infection produces chronic pulmonary epithelial and immune cell dysfunction with fibrosis in mice.	Sci Transl Med	2022
35353667	SARS-CoV-2 infection of airway cells causes intense viral and cell shedding, two spreading mechanisms affected by IL-13.	Proc Natl Acad Sci U S A	2022
34172469	Treatment of cystic fibrosis airway cells with CFTR modulators reverses aberrant mucus properties hydration.	European Respiratory Journal	2022
34801592	Identification of Sputum Biomarkers Predictive of Pulmonary Exacerbations in COPD.	Chest	2022
35194605	A model of persistent post SARS-CoV-2 induced lung disease for target identification and testing of therapeutic strategies.	bioRxiv	2022
34848210	The Precision Interventions for Severe and/or Exacerbation-Prone (PrecISE) Asthma Network: An overview of Network organization, procedures, and interventions.	J Allergy Clin Immunol	2022
34548396	Assembly and organization of the N-terminal region of mucin MUC5AC: Indications for structural and functional distinction from MUC5B.	Proc Natl Acad Sci U S A	2021
33539837	Ratio of FEV<sub>1</sub>/Slow Vital Capacity ofÂ < 0.7 Is Associated With Clinical, Functional, and Radiologic Features of Obstructive Lung Disease in Smokers With Preserved Lung Function.	Chest	2021
33906653	Soluble receptor for advanced glycation end products (sRAGE) as a biomarker of COPD.	Respir Res	2021
33799786	Metabolomic Profiling Reveals Sex Specific Associations with Chronic Obstructive Pulmonary Disease and Emphysema.	Metabolites	2021
34058148	Airway mucin MUC5AC and MUC5B concentrations and the initiation and progression of chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort.	Lancet Respiratory Medicine,The	2021
33674211	SLC26A9 SNP rs7512462 is not associated with lung disease severity or lung function response to ivacaftor in cystic fibrosis patients with G551D-CFTR.	J Cyst Fibros	2021
34103907	Longitudinal Imaging-Based Clusters in Former Smokers of the COPD Cohort Associate with Clinical Characteristics: The SubPopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS).	Int J Chron Obstruct Pulmon Dis	2021
33667479	PrecISE: Precision Medicine in Severe Asthma: An adaptive platform trial with biomarker ascertainment.	J Allergy Clin Immunol	2021
33649381	Latent traits of lung tissue patterns in former smokers derived by dual channel deep learning in computed tomography images.	Sci Rep	2021
33547327	Lung microbiota associations with clinical features of COPD in the SPIROMICS cohort.	NPJ Biofilms Microbiomes	2021
33232302	Phenotypes of CF rabbits generated by CRISPR/Cas9-mediated disruption of the CFTR gene.	JCI Insight	2021
33180550	Mucus Plugs and Emphysema in the Pathophysiology of Airflow Obstruction and Hypoxemia in Smokers.	Am J Respir Crit Care Med	2021
33321047	Secretory Cells Dominate Airway CFTR Expression and Function in Human Airway Superficial Epithelia.	American Journal of Respiratory and Critical Care Medicine	2021
32526206	SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract.	Cell	2020
31800264	Inhibition of ATP hydrolysis restores airway surface liquid production in cystic fibrosis airway epithelia.	American Journal of Physiology - Lung Cellular and Molecular Physiology	2020
32071625	Effectiveness of catheter ablation of atrial fibrillation according to heart failure etiology.	J Arrhythm	2020
31633992	Shocking the System to Achieve Efficient Gene Targeting in Primary Human Airway Epithelia.	American Journal of Respiratory Cell and Molecular Biology	2020
32298651	Regenerative Metaplastic Clones in COPD Lung Drive Inflammation and Fibrosis.	Cell	2020
32386347	Comparison of Proteomic Assessment Methods in Multiple Cohort Studies.	Proteomics	2020
32450244	Clinical Phenotypes of Atopy and Asthma in COPD: A Meta-analysis of SPIROMICS and COPDGene.	Chest	2020
32084371	Phenotypic Characterization and Comparison of Cystic Fibrosis Rat Models Generated Using CRISPR/Cas9 Gene Editing.	American Journal of Pathology	2020
33987620	Plasma Metabolomic Signatures of Chronic Obstructive Pulmonary Disease and the Impact of Genetic Variants on Phenotype-Driven Modules.	Netw Syst Med	2020
32768080	A 79-Year-Old Man With Progressive Dyspnea and Multiple Pulmonary Nodules.	Chest	2020
32601308	Increased airway iron parameters and risk for exacerbation in COPD: an analysis from SPIROMICS.	Sci Rep	2020
32543909	Impact of Regulatory T Cells on Type 2 Alveolar Epithelial Cell Transcriptomes during Resolution of Acute Lung Injury and Contributions of IFN-Î³.	American Journal of Respiratory Cell and Molecular Biology	2020
33253230	Mining GWAS and eQTL data for CF lung disease modifiers by gene expression imputation.	PLoS One	2020
31307479	Imaging-based clusters in former smokers of the COPD cohort associate with clinical characteristics: the SubPopulations and intermediate outcome measures in COPD study (SPIROMICS).	Respir Res	2019
31908441	Clinical Significance of Bronchodilator Responsiveness Evaluated by Forced Vital Capacity in COPD: SPIROMICS Cohort Analysis.	Int J Chron Obstruct Pulmon Dis	2019