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Author Details

Mary F Paine
Washington State University
1996
122
39
PMIDPaper TitleJournal TitlePublished Year
36861661An evaluation of adverse drug reactions and outcomes attributed to kratom in the US Food and Drug Administration Adverse Event Reporting System from January 2004 through September 2021.Clin Transl Sci2023
37541764An Integrative Approach to Elucidate Mechanisms Underlying the Pharmacokinetic Goldenseal-Midazolam Interaction: Application of In Vitro Assays and Physiologically Based Pharmacokinetic Models to Understand Clinical Observations.J Pharmacol Exp Ther2023
37502215Potential pharmacokinetic interactions with concurrent use of herbal medicines and a ritonavir-boosted COVID-19 protease inhibitor in low and middle-income countries.Front Pharmacol2023
37639334Co-consuming green tea with raloxifene decreases raloxifene systemic exposure in healthy adult participants.Clin Transl Sci2023
37286363Translating Kratom-Drug Interactions: From Bedside to Bench and Back.Drug Metab Dispos2023
37313955Evaluation of Cytochrome P450-Mediated Cannabinoid-Drug Interactions in Healthy Adult Participants.Clin Pharmacol Ther2023
37042268Limitations of fexofenadine limited sampling strategy using plasma concentrations and partial area under the concentration-time curve to estimate transporter activity in healthy adults.Int J Clin Pharmacol Ther2023
36972999A Physiologically-Based Pharmacokinetic Model for Cannabidiol in Healthy Adults, Hepatically-Impaired Adults, and Children.Drug Metab Dispos2023
36924284Clinical Assessment of the Drug Interaction Potential of the Psychotropic Natural Product Kratom.Clin Pharmacol Ther2023
36780161Assessment of Orally Administered ο9-Tetrahydrocannabinol When Coadministered With Cannabidiol on ο9-Tetrahydrocannabinol Pharmacokinetics and Pharmacodynamics in Healthy Adults: A Randomized Clinical Trial.JAMA Netw Open2023
36645711Fexofenadine Plasma Concentrations to Estimate Systemic Exposure in Healthy Adults Using a Limited Sampling Strategy with a Population Pharmacokinetic Approach.Ther Drug Monit2023
36933632Developing a Knowledge Graph for Pharmacokinetic Natural Product-Drug Interactions.J Biomed Inform2023
34784423Cannabis for Medical Use: Clinical Pharmacology Perspectives on Scientific and Regulatory Challenges.Clin Pharmacol Ther2022
35115300Comprehensive Predictions of Cytochrome P450 (P450)-Mediated In Vivo Cannabinoid-Drug Interactions Based on Reversible and Time-Dependent P450 Inhibition in Human Liver Microsomes.Drug Metab Dispos2022
35335999Clinical Pharmacokinetic Assessment of Kratom (<i>Mitragyna speciosa</i>), a Botanical Product with Opioid-like Effects, in Healthy Adult Participants.Pharmaceutics2022
35165231A Case of Potential Pharmacokinetic Kratom-drug Interactions Resulting in Toxicity and Subsequent Treatment of Kratom Use Disorder With Buprenorphine/Naloxone.J Addict Med2022
34699676Adapting regulatory drug-drug interaction guidance to design clinical pharmacokinetic natural product-drug interaction studies: A NaPDI Center recommended approach.Clin Transl Sci2022
32460379Intestinal P-gp and Putative Hepatic OATP1B Induction: International Transporter Consortium Perspective on Drug Development Implications.Clin Pharmacol Ther2021
33712517Modeling Pharmacokinetic Natural Product-Drug Interactions for Decision-Making: A NaPDI Center Recommended Approach.Pharmacol Rev2021
33587330Hepatic organic anion transporting polypeptides mediate disposition of milk thistle flavonolignans and pharmacokinetic silymarin-drug interactions.Phytother Res2021
34006613Erratum for Herring et al., "Inhibition of Arenaviruses by Combinations of Orally Available Approved Drugs".Antimicrob Agents Chemother2021
33174626Assessing Transporter-Mediated Natural Product-Drug Interactions Via In vitro-In Vivo Extrapolation: Clinical Evaluation With a Probe Cocktail.Clin Pharmacol Ther2021
33093187Refined Prediction of Pharmacokinetic Kratom-Drug Interactions: Time-Dependent Inhibition Considerations.J Pharmacol Exp Ther2021
33468464Inhibition of Arenaviruses by Combinations of Orally Available Approved Drugs.Antimicrob Agents Chemother2021
32197968"Natural" is not synonymous with "Safe": Toxicity of natural products alone and in combination with pharmaceutical agents.Regul Toxicol Pharmacol2020
33154449Chemical composition and biological effects of kratom (Mitragyna speciosa): In vitro studies with implications for efficacy and drug interactions.Sci Rep2020
32601103A New Data Repository for Pharmacokinetic Natural Product-Drug Interactions: From Chemical Characterization to Clinical Studies.Drug Metab Dispos2020
32591416Modulation of Major Human Liver Microsomal Cytochromes P450 by Component Alkaloids of Goldenseal: Time-Dependent Inhibition and Allosteric Effects.Drug Metab Dispos2020
32816868Natural Products: Experimental Approaches to Elucidate Disposition Mechanisms and Predict Pharmacokinetic Drug Interactions.Drug Metab Dispos2020
32587099Predicting the Potential for Cannabinoids to Precipitate Pharmacokinetic Drug Interactions via Reversible Inhibition or Inactivation of Major Cytochromes P450.Drug Metab Dispos2020
32140423United States Pharmacopeia (USP) comprehensive review of the hepatotoxicity of green tea extracts.Toxicol Rep2020
30387917Effects of Common CYP1A2 Genotypes and Other Key Factors on Intraindividual Variation in the Caffeine Metabolic Ratio: An Exploratory Analysis.Clin Transl Sci2019
31407329The Age of Omics-Driven Precision Medicine.Clin Pharmacol Ther2019
31420525A Pharmacokinetic Natural Product-Disease-Drug Interaction: A Double Hit of Silymarin and Nonalcoholic Steatohepatitis on Hepatic Transporters in a Rat Model.J Pharmacol Exp Ther2019
31071346A marijuana-drug interaction primer: Precipitants, pharmacology, and pharmacokinetics.Pharmacol Ther2019
31028057Indinavir Increases Midazolam <i>N</i>-Glucuronidation in Humans: Identification of an Alternate CYP3A Inhibitor Using an In Vitro to In Vivo Approach.Drug Metab Dispos2019
30849452Nonalcoholic fatty liver disease alters microcystin-LR toxicokinetics and acute toxicity.Toxicon2019
30681109Selection and characterization of botanical natural products for research studies: a NaPDI center recommended approach.Nat Prod Rep2019
29735752Selection of Priority Natural Products for Evaluation as Potential Precipitants of Natural Product-Drug Interactions: A NaPDI Center Recommended Approach.Drug Metab Dispos2018
30151884"Green Medicine": The Past, Present, and Future of Botanicals.Clin Pharmacol Ther2018
30170118Follow that botanical: Challenges and recommendations for assessing absorption, distribution, metabolism and excretion of botanical dietary supplements.Food Chem Toxicol2018
30815066Developing User Personas to Aid in the Design of a User-Centered Natural Product-Drug Interaction Information Resource for Researchers.AMIA Annu Symp Proc2018
29467215Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (<i>Camellia sinensis)</i> Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation.Drug Metab Dispos2018
29761830ITC Commentary on Metformin Clinical Drug-Drug Interaction Study Design That Enables an Efficacy- and Safety-Based Dose Adjustment Decision.Clin Pharmacol Ther2018
29735755Recommended Approaches for Pharmacokinetic Natural Product-Drug Interaction Research: a NaPDI Center Commentary.Drug Metab Dispos2018
28032362Prioritizing pharmacokinetic drug interaction precipitants in natural products: application to OATP inhibitors in grapefruit juice.Biopharm Drug Dispos2017
28453261Comparison of Metabolomics Approaches for Evaluating the Variability of Complex Botanical Preparations: Green Tea (Camellia sinensis) as a Case Study.J Nat Prod2017
28318023Therapeutic disasters that hastened safety testing of new drugs.Clin Pharmacol Ther2017
28504483Comparison of a New Intranasal Naloxone Formulation to Intramuscular Naloxone: Results from Hypothesis-generating Small Clinical Studies.Clin Transl Sci2017
26776752Assessing Natural Product-Drug Interactions: An End-to-End Safety Framework.Regul Toxicol Pharmacol2016
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Collaborators

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Co-authored papers 20
University of Pittsburgh
Co-authored papers 5
Department of Pharmacy and Therapeutics, School of Pharmacy, University of Pittsburgh
Co-authored papers 2
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Co-authored papers 2
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Co-authored papers 2
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Co-authored papers 2
University of California San Francisco
Co-authored papers 1
Drug Metabolism and Pharmacokinetics
Co-authored papers 1
Columbia University
Co-authored papers 1
College of Medicine, University of Arkansas for Medical Sciences
Co-authored papers 1
National Institute of Environmental Health Sciences
Co-authored papers 1
Metabolic Solutions Inc.
Co-authored papers 1
Co-authored papers 1
F. Hoffmann-La Roche Ltd.
Co-authored papers 1
University of Pittsburgh
Co-authored papers 1
The University of Michigan ann arbor
Co-authored papers 1
University of Illinois Urbana-Champaign
Co-authored papers 1
1 Vanderbilt University Medical Center
Co-authored papers 1
E O Lawrence Berkeley National Laboratory, UCSF Medical Center, University of California, Berkeley, University of Chicago
Co-authored papers 1
Clinical Research Section
Co-authored papers 1