Author details

Full Name

Henry R Bourne

Affiliation

ORCID

Career Start Year

1968

Papers

242

H Index

100

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
30154238	Opinion: Expansion fever and soft money plague the biomedical research enterprise.	Proceedings of the National Academy of Sciences of the United States of America	2018
28246298	Lost Dollars Threaten Research in Public Academic Health Centers.	FASEB Journal	2017
27001862	Alfred Gilman: Intrepid, committed scientist.	Proceedings of the National Academy of Sciences of the United States of America	2016
25649813	Is 6 years too long to get a Ph.D. in Biomedical Science?	FASEB Journal	2015
23539544	The writing on the wall.	eLife	2013
24137543	A fair deal for PhD students and postdocs.	eLife	2013
23878729	A recipe for mediocrity and disaster, in five axioms.	eLife	2013
22767896	Iceberg alert for NIH.	Science	2012
19724256	Ambition, surprise and delight: necessary lessons.	Nature Cell Biology	2009
18086913	PDZRhoGEF and myosin II localize RhoA activity to the back of polarizing neutrophil-like cells.	Journal of Cell Biology	2007
17517645	Polarity reveals intrinsic cell chirality.	Proceedings of the National Academy of Sciences of the United States of America	2007
17684096	Bound attractant at the leading vs. the trailing edge determines chemotactic prowess.	Proceedings of the National Academy of Sciences of the United States of America	2007
16537448	Neutrophil polarization: spatiotemporal dynamics of RhoA activity support a self-organizing mechanism.	Proceedings of the National Academy of Sciences of the United States of America	2006
17703575	G-proteins and GPCrs: from the beginning.		2006
17021383	Morphology matters in immune cell chemotaxis: membrane asymmetry affects amplification.	Phys Biol	2006
16871217	Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN.	Nature	2006
16417406	Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis.	PLoS Biol	2006
16864657	To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front.	J Cell Biol	2006
16056271	Rac and cell migration: CDM proteins integrate signals.	Nature Cell Biology	2005
15550394	Site-specific disulfide capture of agonist and antagonist peptides on the C5a receptor.	J Biol Chem	2005
15860582	Neutrophil microtubules suppress polarity and enhance directional migration.	Proceedings of the National Academy of Sciences of the United States of America	2005
12589067	Hepatocyte growth factor switches orientation of polarity and mode of movement during morphogenesis of multicellular epithelial structures.	Molecular Biology of the Cell	2003
12551955	Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis.	Journal of Cell Biology	2003
14654007	Q & A.	Current Biology	2003
12887922	Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils.	Cell	2003
12478302	Unravelling the signal-transduction network in B lymphocytes.	Nature	2002
12453150	Constitutive activation and endocytosis of the complement factor 5a receptor: evidence for multiple activated conformations of a G protein-coupled receptor.	Traffic	2002
12214215	A chemical compass.	Nature	2002
12080346	A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity.	Nature Cell Biology	2002
12080345	Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils.	Nature Cell Biology	2002
12478301	Overview of the Alliance for Cellular Signaling.	Nature	2002
11344266	Mutant G protein alpha subunit activated by Gbeta gamma: a model for receptor activation?	Proc Natl Acad Sci U S A	2001
11698103	Receptor activation: what does the rhodopsin structure tell us?	Trends Pharmacol Sci	2001
11062244	An activation switch in the ligand binding pocket of the C5a receptor.	J Biol Chem	2001
10655488	Localization of a peripheral membrane protein: Gbetagamma targets Galpha(Z).	Proceedings of the National Academy of Sciences of the United States of America	2000
10950717	Structure. Rhodopsin sees the light.	Science	2000
10669415	Polarization of chemoattractant receptor signaling during neutrophil chemotaxis.	Science	2000
11050418	Leukocytes navigate by compass: roles of PI3Kgamma and its lipid products.	Trends in Cell Biology	2000
10336477	C5a receptor activation. Genetic identification of critical residues in four transmembrane helices.	J Biol Chem	1999
9915816	Galphai is not required for chemotaxis mediated by Gi-coupled receptors.	Journal of Biological Chemistry	1999
9892662	A Gsalpha mutant designed to inhibit receptor signaling through Gs.	Proceedings of the National Academy of Sciences of the United States of America	1999
10099144	The expanding spectrum of G protein diseases.	New England Journal of Medicine	1999
10373496	Gbetagamma and palmitate target newly synthesized Galphaz to the plasma membrane.	Journal of Biological Chemistry	1999
10559877	Spatial control of actin polymerization during neutrophil chemotaxis.	Nature Cell Biology	1999
10607574	A necessary hero.	Current Biology	1999
10358054	Similar structures and shared switch mechanisms of the beta2-adrenoceptor and the parathyroid hormone receptor. Zn(II) bridges between helices III and VI block activation.	J Biol Chem	1999
10198064	Dynamics of a chemoattractant receptor in living neutrophils during chemotaxis.	Molecular Biology of the Cell	1999
9425887	G proteins propel surprise.	Nature Genetics	1998
9665125	G-protein diseases furnish a model for the turn-on switch.	Nature	1998
9786851	Second site suppressor mutations of a GTPase-deficient G-protein alpha-subunit. Selective inhibition of Gbeta gamma-mediated signaling.	Journal of Biological Chemistry	1998