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Author Details

Marc van de Wetering
Princess Maxima Center for Pediatric Oncology
1991
99
73
PMIDPaper TitleJournal TitlePublished Year
37020038Atypical teratoid/rhabdoid tumoroids reveal subgroup-specific drug vulnerabilities.Oncogene2023
37883554Unbiased transcription factor CRISPR screen identifies ZNF800 as master repressor of enteroendocrine differentiation.Science2023
37823774Ewing Sarcoma Single-cell Transcriptome Analysis Reveals Functionally Impaired Antigen-presenting Cells.Cancer Res Commun2023
35916583Mesenchymal tumor organoid models recapitulate rhabdomyosarcoma subtypes.EMBO Mol Med2022
35469014Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR ÿ LGR5 bispecific antibody with efficacy in epithelial tumors.Nat Cancer2022
34885181EWSR1-WT1 Target Genes and Therapeutic Options Identified in a Novel DSRCT In Vitro Model.Cancers (Basel)2021
33500353Single-cell atlas of developing murine adrenal gland reveals relation of Schwann cell precursor signature to neuroblastoma phenotype.Proc Natl Acad Sci U S A2021
31036964Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids.Nat Genet2019
31843916Enteroendocrine and tuft cells support Lgr5 stem cells on Paneth cell depletion.Proc Natl Acad Sci U S A2019
31282586Xenograft and organoid model systems in cancer research.EMBO J2019
29311336Troy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy.Proc Natl Acad Sci U S A2018
29643510Intra-tumour diversification in colorectal cancer at the single-cell level.Nature2018
28052255Personalized Proteome Profiles of Healthy and Tumor Human Colon Organoids Reveal Both Individual Diversity and Basic Features of Colorectal Cancer.Cell Rep2017
28850106FANTOM5 CAGE profiles of human and mouse samples.Sci Data2017
28716720MET Signaling Mediates Intestinal Crypt-Villus Development, Regeneration, and Adenoma Formation and Is Promoted by Stem Cell CD44 Isoforms.Gastroenterology2017
28684519Origins of lymphatic and distant metastases in human colorectal cancer.Science2017
27698416Tissue-specific mutation accumulation in human adult stem cells during life.Nature2016
25307862In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection.Gastroenterology2015
26460009Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases.Proc Natl Acad Sci U S A2015
25924068Sequential cancer mutations in cultured human intestinal stem cells.Nature2015
25957691Prospective derivation of a living organoid biobank of colorectal cancer patients.Cell2015
25712196Germline deletions in the tumour suppressor gene FOCAD are associated with polyposis and colorectal cancer development.J Pathol2015
25533785Long-term culture of genome-stable bipotent stem cells from adult human liver.Cell2015
23318432Stem cell CD44v isoforms promote intestinal cancer formation in Apc(min) mice downstream of Wnt signaling.Oncogene2014
25500896Transformation of intestinal stem cells into gastric stem cells on loss of transcription factor Cdx2.Nat Commun2014
25043003Genome sequencing of normal cells reveals developmental lineages and mutational processes.Nature2014
24670764A promoter-level mammalian expression atlas.Nature2014
23354049In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration.Nature2013
24045232Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis.EMBO J2013
24120136Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium.Cell2013
23714178DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus.Genome Biol2013
23545496ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response.Cell Rep2013
22388892Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling.Nat Cell Biol2012
23000963Dll1+ secretory progenitor cells revert to stem cells upon crypt damage.Nat Cell Biol2012
22999937Lgr5(+ve) stem/progenitor cells contribute to nephron formation during kidney development.Cell Rep2012
22692129The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers.EMBO J2012
22895187Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors.Nature2012
22855427Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas.Science2012
21113151Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts.Nature2011
22081019Single-cell dissection of transcriptional heterogeneity in human colon tumors.Nat Biotechnol2011
21727895Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.Nature2011
21696214Highly sensitive proteome analysis of FACS-sorted adult colon stem cells.J Proteome Res2011
21297579Lgr5 intestinal stem cells have high telomerase activity and randomly segregate their chromosomes.EMBO J2011
20085740Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro.Cell Stem Cell2010
21152096Efficient double fragmentation ChIP-seq provides nucleotide resolution protein-DNA binding profiles.PLoS One2010
20223988Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin.Science2010
19013005Identification of primary MAFB target genes in multiple myeloma.Exp Hematol2009
19329995Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche.Nature2009
19450592OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells.Gastroenterology2009
19092804Crypt stem cells as the cells-of-origin of intestinal cancer.Nature2009
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Collaborators

Hans Clevers
Princess Maxima Center for Pediatric Oncology
Co-authored papers 95
Edwin Cuppen
Hartwig Medical Foundation
Co-authored papers 8
Frank C P Holstege
Princess Maxima Center for Pediatric Oncology
Co-authored papers 6
Albert J R Heck
Utrecht University
Co-authored papers 5
Jan Koster
Amsterdam University Medical Centers location AMC
Co-authored papers 5
Michael R Stratton
Wellcome Sanger Institute
Co-authored papers 5
Thanasis Margaritis
Princess Maxima Center for Pediatric Oncology
Co-authored papers 3
Tony J Kenna
Queensland University of Technology
Co-authored papers 2
Marielle E van Gijn
University Medical Center Groningen
Co-authored papers 2
Peter Zhang
Child and Family Research Institute, University of British Columbia
Co-authored papers 2
Naoto Kondo
Nagoya City University Graduate School of Medical Sciences
Co-authored papers 2
Takaaki Sugiyama
Co-authored papers 2
Jun Furusawa
Aichi Cancer Center Hospital
Co-authored papers 2
Guojun Sheng
International Research Center for Medical Sciences (IRCMS), Kumamoto University
Co-authored papers 2
Yosuke Mizuno
Yokohama National University
Co-authored papers 2
Haruhiko Koseki
RIKEN Research Center for Allergy and Immunology
Co-authored papers 2
Stefano Gustincich
Istituto Italiano di Tecnologia
Co-authored papers 2
Yuki I Kawamura
Research Institute, National Center for Global Health and Medicine
Co-authored papers 2
Reto Guler
International Centre for Genetic Engineering and Biotechnology
Co-authored papers 2
Albert S B Edge
Harvard Medical School
Co-authored papers 2
Christophe Simon
RIKEN Yokohama Institute
Co-authored papers 2
Peter Heutink
German Center for Neurodegenerative Diseases (DZNE).
Co-authored papers 2
Ernst J Wolvetang
Australian Institute for Bioengineering and Nanotechnology, University of Queensland
Co-authored papers 2
Suzana Savvi
South African Medical Research Council (SAMRC), University of Cape Town
Co-authored papers 2
Soichi Ogishima
Tohoku University Graduate School of Medicine
Co-authored papers 2
Christine L Mummery
Leiden University Medical Center
Co-authored papers 2
Weonju Lee
Kyungpook National University, Kyungpook National University Hospital
Co-authored papers 2
Yohei Yonekura
RIKEN Center for Developmental Biology
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Release 1.2