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Author Details

Roman Yelensky
2003
83
56
PMIDPaper TitleJournal TitlePublished Year
35970920Individualized, heterologous chimpanzee adenovirus and self-amplifying mRNA neoantigen vaccine for advanced metastatic solid tumors: phase 1 trial interim results.Nat Med2022
30770496Correction: RAS/MAPK Activation Is Associated with Reduced Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer: Therapeutic Cooperation Between MEK and PD-1/PD-L1 Immune Checkpoint Inhibitors.Clin Cancer Res2019
29415044A computational approach to distinguish somatic vs. germline origin of genomic alterations from deep sequencing of cancer specimens without a matched normal.PLoS Comput Biol2018
29751996Update on Tumor Neoantigens and Their Utility: Why It Is Good to Be Different.Trends Immunol2018
27908594Rucaparib in relapsed, platinum-sensitive high-grade ovarian carcinoma (ARIEL2 Part 1): an international, multicentre, open-label, phase 2 trial.Lancet Oncol2017
28794284Genomic profiling of ER<sup>+</sup> breast cancers after short-term estrogen suppression reveals alterations associated with endocrine resistance.Sci Transl Med2017
28525389Biological and clinical evidence for somatic mutations in BRCA1 and BRCA2 as predictive markers for olaparib response in high-grade serous ovarian cancers in the maintenance setting.Oncotarget2017
27291498Unique genomic features in adolescent and young adult, as compared to older adult, non-Hodgkin lymphoma and potential therapeutic targets.Br J Haematol2017
27363283Patient-derived xenotransplants can recapitulate the genetic driver landscape of acute leukemias.Leukemia2017
27489863Presence of both alterations in FGFR/FGF and PI3K/AKT/mTOR confer improved outcomes for patients with metastatic breast cancer treated with PI3K/AKT/mTOR inhibitors.Oncoscience2016
27197177Cancer Therapy Directed by Comprehensive Genomic Profiling: A Single Center Study.Cancer Res2016
26933124Comprehensive Genomic Profiling Identifies Frequent Drug-Sensitive EGFR Exon 19 Deletions in NSCLC not Identified by Prior Molecular Testing.Clin Cancer Res2016
27245569Comprehensive Genomic Profiling Identifies a Subset of Crizotinib-Responsive ALK-Rearranged Non-Small Cell Lung Cancer Not Detected by Fluorescence In Situ Hybridization.Oncologist2016
26966091Integrated genomic DNA/RNA profiling of hematologic malignancies in the clinical setting.Blood2016
27284958Nonamplification ERBB2 genomic alterations in 5605 cases of recurrent and metastatic breast cancer: An emerging opportunity for anti-HER2 targeted therapies.Cancer2016
27052656Comprehensive genomic profiling of anal squamous cell carcinoma reveals distinct genomically defined classes.Ann Oncol2016
27334835Profiling of 149 Salivary Duct Carcinomas, Carcinoma Ex Pleomorphic Adenomas, and Adenocarcinomas, Not Otherwise Specified Reveals Actionable Genomic Alterations.Clin Cancer Res2016
27075627Triple-negative breast cancers with amplification of JAK2 at the 9p24 locus demonstrate JAK2-specific dependence.Sci Transl Med2016
27207748Comprehensive Genomic Profiling of Clinically Advanced Medullary Thyroid Carcinoma.Oncology2016
27466356TP53 Alterations Correlate with Response to VEGF/VEGFR Inhibitors: Implications for Targeted Therapeutics.Mol Cancer Ther2016
26479420Evaluation of 122 advanced-stage cutaneous squamous cell carcinomas by comprehensive genomic profiling opens the door for new routes to targeted therapies.Cancer2016
26314551The distribution of BRAF gene fusions in solid tumors and response to targeted therapy.Int J Cancer2016
26651075Comprehensive genomic profiling of 295 cases of clinically advanced urothelial carcinoma of the urinary bladder reveals a high frequency of clinically relevant genomic alterations.Cancer2016
26515496RAS/MAPK Activation Is Associated with Reduced Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer: Therapeutic Cooperation Between MEK and PD-1/PD-L1 Immune Checkpoint Inhibitors.Clin Cancer Res2016
26500333Comprehensive genomic profiling of extrahepatic cholangiocarcinoma reveals a long tail of therapeutic targets.J Clin Pathol2016
26149668Characterization of Clinical Cases of Collecting Duct Carcinoma of the Kidney Assessed by Comprehensive Genomic Profiling.Eur Urol2016
26670666Comprehensive Genomic Profiling of Advanced Penile Carcinoma Suggests a High Frequency of Clinically Relevant Genomic Alterations.Oncologist2016
27566247Clinical Actionability of Comprehensive Genomic Profiling for Management of Rare or Refractory Cancers.Oncologist2016
26664139A metastatic colon adenocarcinoma harboring BRAF V600E has a durable major response to dabrafenib/trametinib and chemotherapy.Onco Targets Ther2015
25927147Genomic profiling of advanced-stage, metaplastic breast carcinoma by next-generation sequencing reveals frequent, targetable genomic abnormalities and potential new treatment options.Arch Pathol Lab Med2015
25886620Next generation sequencing of exceptional responders with BRAF-mutant melanoma: implications for sensitivity and resistance.BMC Cancer2015
25712460Genomic alterations in head and neck squamous cell carcinoma determined by cancer gene-targeted sequencing.Ann Oncol2015
25882375Prospective comprehensive genomic profiling of advanced gastric carcinoma cases reveals frequent clinically relevant genomic alterations and new routes for targeted therapies.Oncologist2015
25797355Comparative analysis of primary tumour and matched metastases in colorectal cancer patients: evaluation of concordance between genomic and transcriptional profiles.Eur J Cancer2015
25546157RET fusion as a novel driver of medullary thyroid carcinoma.J Clin Endocrinol Metab2015
25871911Genomic alterations in DNA repair and chromatin remodeling genes in estrogen receptor-positive metastatic breast cancer patients with exceptional responses to capecitabine.Cancer Med2015
25658984Comprehensive genomic profiling identifies a novel TNKS2-PDGFRA fusion that defines a myeloid neoplasm with eosinophilia that responded dramatically to imatinib therapy.Blood Cancer J2015
25480824Oncogenic alterations in ERBB2/HER2 represent potential therapeutic targets across tumors from diverse anatomic sites of origin.Oncologist2015
25680375Lung Master Protocol (Lung-MAP)-A Biomarker-Driven Protocol for Accelerating Development of Therapies for Squamous Cell Lung Cancer: SWOG S1400.Clin Cancer Res2015
25971938Activation of MET via diverse exon 14 splicing alterations occurs in multiple tumor types and confers clinical sensitivity to MET inhibitors.Cancer Discov2015
26563356Evaluation of a Congenital Infantile Fibrosarcoma by Comprehensive Genomic Profiling Reveals an LMNA-NTRK1 Gene Fusion Responsive to Crizotinib.J Natl Cancer Inst2015
26182302Comprehensive Genomic Profiling of Carcinoma of Unknown Primary Site: New Routes to Targeted Therapies.JAMA Oncol2015
26336083Comprehensive Genomic Profiling of Advanced Esophageal Squamous Cell Carcinomas and Esophageal Adenocarcinomas Reveals Similarities and Differences.Oncologist2015
26244165Durable clinical benefit to trastuzumab and chemotherapy in a patient with metastatic colon adenocarcinoma harboring ERBB2 amplification.Oncoscience2015
26370156RICTOR Amplification Defines a Novel Subset of Patients with Lung Cancer Who May Benefit from Treatment with mTORC1/2 Inhibitors.Cancer Discov2015
26238431Defects in DNA Repair Genes Predict Response to Neoadjuvant Cisplatin-based Chemotherapy in Muscle-invasive Bladder Cancer.Eur Urol2015
26021831Multiple gene aberrations and breast cancer: lessons from super-responders.BMC Cancer2015
25078331Next-generation sequencing of adrenocortical carcinoma reveals new routes to targeted therapies.J Clin Pathol2014
25490892Loss of heterozygosity at the CYP2D6 locus in breast cancer: implications for germline pharmacogenetic studies.J Natl Cancer Inst2014
25266736Comprehensive genomic profiling of pancreatic acinar cell carcinomas identifies recurrent RAF fusions and frequent inactivation of DNA repair genes.Cancer Discov2014
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