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Author Details

Norman A Mazer
1977
80
39
PMIDPaper TitleJournal TitlePublished Year
36454709Development of a quantitative semi-mechanistic model of Alzheimer's disease based on the amyloid/tau/neurodegeneration framework (the Q-ATN model).Alzheimers Dement2023
35676943In silico exploration of amyloid-related imaging abnormalities in the gantenerumab open-label extension trials using a semi-mechanistic model.Alzheimer's and Dementia: Translational Research and Clinical Interventions2022
31876425Ocular Half-Life of Intravitreal Biologics in Humans and Other Species: Meta-Analysis and Model-Based Prediction.Molecular Pharmaceutics2020
37283687Quantitative proteomic profiling of white matter in cases of cerebral amyloid angiopathy reveals upregulation of extracellular matrix proteins and clusterin.2020
32407522Does the Fc Region Have a Role in the Ocular Half-life After Intravitreal Injection?Investigative Ophthalmology and Visual Science2020
31834136Correspondence.Retina2020
31593554Bitopertin, a selective oral GLYT1 inhibitor, improves anemia in a mouse model of β-thalassemia.JCI insight2019
29734810Theoretical Insights into the Retinal Dynamics of Vascular Endothelial Growth Factor in Patients Treated with Ranibizumab, Based on an Ocular Pharmacokinetic/Pharmacodynamic Model.Molecular Pharmaceutics2018
28442497An in silico model of retinal cholesterol dynamics (RCD model): insights into the pathophysiology of dry AMD.Journal of Lipid Research2017
28631484Ocular Pharmacokinetics of Therapeutic Antibodies Given by Intravitreal Injection: Estimation of Retinal Permeabilities Using a 3-Compartment Semi-Mechanistic Model.Molecular Pharmaceutics2017
26522778Evaluation of HDL-modulating interventions for cardiovascular risk reduction using a systems pharmacology approach.Journal of Lipid Research2016
26726925A Mechanistic Model of the Intravitreal Pharmacokinetics of Large Molecules and the Pharmacodynamic Suppression of Ocular Vascular Endothelial Growth Factor Levels by Ranibizumab in Patients with Neovascular Age-Related Macular Degeneration.Molecular Pharmaceutics2016
26380155Analysis of "On/Off" Kinetics of a CETP Inhibitor Using a Mechanistic Model of Lipoprotein Metabolism and Kinetics.CPT: Pharmacometrics and Systems Pharmacology2015
26262795Effects of Testosterone Administration for 3 Years on Subclinical Atherosclerosis Progression in Older Men With Low or Low-Normal Testosterone Levels: A Randomized Clinical Trial.JAMA2015
24625468An in-silico model of lipoprotein metabolism and kinetics for the evaluation of targets and biomarkers in the reverse cholesterol transport pathway.PLoS Computational Biology2014
24281237Testosterone dose-response relationships in hysterectomized women with or without oophorectomy: effects on sexual function, body composition, muscle performance and physical function in a randomized trial.Menopause2014
23606523A model-based approach to predict longitudinal HbA1c, using early phase glucose data from type 2 diabetes mellitus patients after anti-diabetic treatment.Journal of Clinical Pharmacology2013
23307170A semi-mechanistic model of the relationship between average glucose and HbA1c in healthy and diabetic subjects.Journal of Pharmacokinetics and Pharmacodynamics2013
23426429A comparison of the theoretical relationship between HDL size and the ratio of HDL cholesterol to apolipoprotein A-I with experimental results from the Women's Health Study.Clin Chem2013
23165659Effect of testosterone replacement on response to sildenafil citrate in men with erectile dysfunction: a parallel, randomized trial.Ann Intern Med2012
22396515Effect of testosterone supplementation with and without a dual 5α-reductase inhibitor on fat-free mass in men with suppressed testosterone production: a randomized controlled trial.JAMA2012
21697501Clinical meaningfulness of the changes in muscle performance and physical function associated with testosterone administration in older men with mobility limitation.J Gerontol A Biol Sci Med Sci2011
21788538Cardiovascular risk prediction in diabetic men and women using hemoglobin A1c vs diabetes as a high-risk equivalent.Arch Intern Med2011
20534765The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men.J Clin Endocrinol Metab2010
20592293Adverse events associated with testosterone administration.N Engl J Med2010
18996225Effects of testosterone therapy on muscle performance and physical function in older men with mobility limitations (The TOM Trial): design and methods.Contemp Clin Trials2009
19321131A novel spreadsheet method for calculating the free serum concentrations of testosterone, dihydrotestosterone, estradiol, estrone and cortisol: with illustrative examples from male and female populations.Steroids2009
19333165The impact of opioids on the endocrine system.Clinical Journal of Pain2009
18303079A comparison of the short-term effects of oral conjugated equine estrogens versus transdermal estradiol on C-reactive protein, other serum markers of inflammation, and other hepatic proteins in naturally menopausal women.Journal of Clinical Endocrinology and Metabolism2008
17507833A randomized, open-label, crossover study comparing the effects of oral versus transdermal estrogen therapy on serum androgens, thyroid hormones, and adrenal hormones in naturally menopausal women.Menopause2007
17105798Effect of testosterone replacement therapy on prostate tissue in men with late-onset hypogonadism: a randomized controlled trial.JAMA2006
16516826Open-label pilot study of testosterone patch therapy in men with opioid-induced androgen deficiency.Journal of Pain2006
16912120Differences in the apparent metabolic clearance rate of testosterone in young and older men with gonadotropin suppression receiving graded doses of testosterone.J Clin Endocrinol Metab2006
16932274Drug insight: Testosterone and selective androgen receptor modulators as anabolic therapies for chronic illness and aging.Nat Clin Pract Endocrinol Metab2006
16422889Comparison of the steady-state pharmacokinetics, metabolism, and variability of a transdermal testosterone patch versus a transdermal testosterone gel in hypogonadal men.Journal of Sexual Medicine2005
16174721A pilot study of an investigational testosterone transdermal patch system in young women with spontaneous premature ovarian failure.Journal of Clinical Endocrinology and Metabolism2005
16422890Transfer of transdermally applied testosterone to clothing: a comparison of a testosterone patch versus a testosterone gel.Journal of Sexual Medicine2005
15142374Interaction of estrogen therapy and thyroid hormone replacement in postmenopausal women.Thyroid2004
16422987Endocrine aspects of female sexual dysfunction.J Sex Med2004
12832941Transdermal testosterone for women: a new physiological approach for androgen therapy.Obstetrical and Gynecological Survey2003
14560750Safety profile of transdermal testosterone therapy in women.American Journal of Obstetrics and Gynecology2003
11991434Testosterone deficiency in women: etiologies, diagnosis, and emerging treatments.International Journal of Fertility and Women's Medicine2002
11238481Interrelationships among lipoprotein levels, sex hormones, anthropometric parameters, and age in hypogonadal men treated for 1 year with a permeation-enhanced testosterone transdermal system.Journal of Clinical Endocrinology and Metabolism2001
10902784Pharmacokinetics of a novel testosterone matrix transdermal system in healthy, premenopausal women and women infected with the human immunodeficiency virus.J Clin Endocrinol Metab2000
10699290New clinical applications of transdermal testosterone delivery in men and women.Journal of Controlled Release2000
10993034The brief index of sexual functioning for women (BISF-W): a new scoring algorithm and comparison of normative and surgically menopausal populations.Menopause2000
10974131Transdermal testosterone treatment in women with impaired sexual function after oophorectomy.New England Journal of Medicine2000
10522982Pharmacokinetics, efficacy, and safety of a permeation-enhanced testosterone transdermal system in comparison with bi-weekly injections of testosterone enanthate for the treatment of hypogonadal men.Journal of Clinical Endocrinology and Metabolism1999
10594158Bone mineral density and androgen levels in elderly males.Calcified Tissue International1999
9543161The use of a sensitive equilibrium dialysis method for the measurement of free testosterone levels in healthy, cycling women and in human immunodeficiency virus-infected women.J Clin Endocrinol Metab1998
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