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Author Details

Scott A Armstrong
Boston Children's Hospital
1990
207
74
Timothy Clark (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
38096371Mezigdomide is effective alone and in combination with menin inhibition in preclinical models of KMT2A-r and NPM1c AML.Blood2024
38010951The future of HOXA- expressing leukemias: Menin inhibitor response and resistance.Curr Opin Hematol2024
38096371Mezigdomide is effective alone and in combination with menin inhibition in preclinical models of KMT2A-r and NPM1c AML.Blood2024
38010951The future of HOXA- expressing leukemias: Menin inhibitor response and resistance.Curr Opin Hematol2024
36264143A Molecular Switch between Mammalian MLL Complexes Dictates Response to Menin-MLL Inhibition.Cancer Discov2023
36264143A Molecular Switch between Mammalian MLL Complexes Dictates Response to Menin-MLL Inhibition.Cancer Discov2023
37591951KDM6A epigenetically regulates subtype plasticity in small cell lung cancer.Nat Cell Biol2023
37648862Epitope editing enables targeted immunotherapy of acute myeloid leukaemia.Nature2023
38049829Immunoproteasome function maintains oncogenic gene expression in KMT2A-complex driven leukemia.Mol Cancer2023
37478846UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability.Mol Cell2023
37261974MLL3 regulates the <i>CDKN2A</i> tumor suppressor locus in liver cancer.Elife2023
36922593The menin inhibitor revumenib in KMT2A-rearranged or NPM1-mutant leukaemia.Nature2023
36922589MEN1 mutations mediate clinical resistance to menin inhibition.Nature2023
36455613Mutant NPM1 Directly Regulates Oncogenic Transcription in Acute Myeloid Leukemia.Cancer Discov2023
37591951KDM6A epigenetically regulates subtype plasticity in small cell lung cancer.Nat Cell Biol2023
37478846UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability.Mol Cell2023
37648862Epitope editing enables targeted immunotherapy of acute myeloid leukaemia.Nature2023
38049829Immunoproteasome function maintains oncogenic gene expression in KMT2A-complex driven leukemia.Mol Cancer2023
37261974MLL3 regulates the <i>CDKN2A</i> tumor suppressor locus in liver cancer.Elife2023
36922593The menin inhibitor revumenib in KMT2A-rearranged or NPM1-mutant leukaemia.Nature2023
36922589MEN1 mutations mediate clinical resistance to menin inhibition.Nature2023
36455613Mutant NPM1 Directly Regulates Oncogenic Transcription in Acute Myeloid Leukemia.Cancer Discov2023
34582559The menin-MLL1 interaction is a molecular dependency in NUP98-rearranged AML.Blood2022
35523139Antigen presentation safeguards the integrity of the hematopoietic stem cell pool.Cell Stem Cell2022
35443279SETD2 Haploinsufficiency Enhances Germinal Center-Associated AICDA Somatic Hypermutation to Drive B-cell Lymphomagenesis.Cancer Discov2022
35499757MOZ and Menin-MLL Complexes Are Complementary Regulators of Chromatin Association and Transcriptional Output in Gastrointestinal Stromal Tumor.Cancer Discov2022
35534777IKAROS and MENIN coordinate therapeutically actionable leukemogenic gene expression in MLL-r acute myeloid leukemia.Nat Cancer2022
34465866YBX1 mediates translation of oncogenic transcripts to control cell competition in AML.Leukemia2022
35245435MLL::AF9 degradation induces rapid changes in transcriptional elongation and subsequent loss of an active chromatin landscape.Mol Cell2022
35078859Bone Marrow Surveillance of Pediatric Cancer Survivors Identifies Clones that Predict Therapy-Related Leukemia.Clin Cancer Res2022
35072375Menin Inhibitors in Acute Myeloid Leukemia-What Does the Future Hold?Cancer J2022
34582559The menin-MLL1 interaction is a molecular dependency in NUP98-rearranged AML.Blood2022
35443279SETD2 Haploinsufficiency Enhances Germinal Center-Associated AICDA Somatic Hypermutation to Drive B-cell Lymphomagenesis.Cancer Discov2022
35534777IKAROS and MENIN coordinate therapeutically actionable leukemogenic gene expression in MLL-r acute myeloid leukemia.Nat Cancer2022
35499757MOZ and Menin-MLL Complexes Are Complementary Regulators of Chromatin Association and Transcriptional Output in Gastrointestinal Stromal Tumor.Cancer Discov2022
35523139Antigen presentation safeguards the integrity of the hematopoietic stem cell pool.Cell Stem Cell2022
35072375Menin Inhibitors in Acute Myeloid Leukemia-What Does the Future Hold?Cancer J2022
35245435MLL::AF9 degradation induces rapid changes in transcriptional elongation and subsequent loss of an active chromatin landscape.Mol Cell2022
35078859Bone Marrow Surveillance of Pediatric Cancer Survivors Identifies Clones that Predict Therapy-Related Leukemia.Clin Cancer Res2022
34465866YBX1 mediates translation of oncogenic transcripts to control cell competition in AML.Leukemia2022
32730721IL-1α Modulates IFN-γ-Induced Production of CXCL9/MIG during Herpes Simplex Virus Type-1 Corneal Infection.Curr Eye Res2021
34156981Taspase1 orchestrates fetal liver hematopoietic stem cell and vertebrae fates by cleaving TFIIA.JCI Insight2021
34210975High-resolution characterization of gene function using single-cell CRISPR tiling screen.Nat Commun2021
33451979HAND1 and BARX1 Act as Transcriptional and Anatomic Determinants of Malignancy in Gastrointestinal Stromal Tumor.Clin Cancer Res2021
33879367Histone PTM Crosstalk Stimulates Dot1 Methyltransferase Activity.Trends Biochem Sci2021
32730721IL-1α Modulates IFN-γ-Induced Production of CXCL9/MIG during Herpes Simplex Virus Type-1 Corneal Infection.Curr Eye Res2021
33879367Histone PTM Crosstalk Stimulates Dot1 Methyltransferase Activity.Trends Biochem Sci2021
34156981Taspase1 orchestrates fetal liver hematopoietic stem cell and vertebrae fates by cleaving TFIIA.JCI Insight2021
34210975High-resolution characterization of gene function using single-cell CRISPR tiling screen.Nat Commun2021
33451979HAND1 and BARX1 Act as Transcriptional and Anatomic Determinants of Malignancy in Gastrointestinal Stromal Tumor.Clin Cancer Res2021
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Collaborators

Richard Koche
Memorial Sloan Kettering Cancer Center
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Amit U Sinha
Memorial Sloan Kettering Cancer Center
Co-authored papers 21
Aniruddha J Deshpande
Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 14
Nan Zhu
Shanghai General Hospital, Shanghai Jiaotong University
Co-authored papers 12
Charlie Hatton
Co-authored papers 12
James E Bradner
Co-authored papers 12
Elisa de Stanchina
Co-authored papers 9
Ari Melnick
Co-authored papers 9
Gerard M McGeehan
Co-authored papers 8
Benjamin L Ebert
Co-authored papers 8
Alex Kentsis
Memorial Sloan-Kettering Cancer Center
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Todd R Golub
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Christopher Y Park
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Brenton G Mar
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Stuart H Orkin
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Vincent A Miller
Injury Prevention Research Center, University of North Carolina
Co-authored papers 4
David E Root
Broad Institute of Harvard and MIT
Co-authored papers 4
David T Scadden
Co-authored papers 4
Christopher E Mason
Feil Family Brain and Mind Research Institute.
Co-authored papers 4
Robert G Roeder
the Rockefeller University
Co-authored papers 4
Richard M Stone
Dana Farber Cancer Institute
Co-authored papers 4
Eric Still
Co-authored papers 4
Brian J P Huntly
University of Cambridge
Co-authored papers 4
Yana Pikman
Dana Farber Cancer Institute
Co-authored papers 4
Victoria M Richon
Discovery and Preclinical Sciences
Co-authored papers 4
Release 1.2