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Author Details

Brian H Shirts
Institute for Public Health Genetics, University of Washington
2000
117
30
PMIDPaper TitleJournal TitlePublished Year
37752309Risk perception and intended behavior change after uninformative genetic results for adult-onset hereditary conditions in unselected patients.Eur J Hum Genet2024
36451272Modeling the impact of data sharing on variant classification.J Am Med Inform Assoc2023
37751715ConnectMyVariant: An Innovative Use of Technology and Social Networks to Realize the Benefits of Cascade Screening.Public Health Genomics2023
37905042Assigning credit where it's due: An information content score to capture the clinical value of Multiplexed Assays of Variant Effect.bioRxiv2023
37897815Exploring Stakeholders' Perspectives on Implementing Universal Germline Testing for Colorectal Cancer: Findings From a Clinical Practice Survey.JCO Precis Oncol2023
37604133Factors Influencing Genetic Screening Enrollment among a Diverse, Community-Ascertained Cohort.Public Health Genomics2023
37384863Practices and Views of US Oncologists and Genetic Counselors Regarding Patient Recontact After Variant Reclassification: Results of a Nationwide Survey.JCO Precis Oncol2023
37079361Extended Family Outreach in Hereditary Cancer Using Web-Based Genealogy, Direct-to-Consumer Ancestry Genetics, and Social Media: Mixed Methods Process Evaluation of the ConnectMyVariant Intervention.JMIR Cancer2023
36971772Laboratory perspectives in the development of polygenic risk scores for disease: A points to consider statement of the American College of Medical Genetics and Genomics (ACMG).Genet Med2023
37069702Diagnostic yield of genetic screening in a diverse, community-ascertained cohort.Genome Med2023
37293588Current chemoprevention approaches in Lynch syndrome and Familial adenomatous polyposis: a global clinical practice survey.Front Oncol2023
36753473Using species richness calculations to model the global profile of unsampled pathogenic variants: Examples from BRCA1 and BRCA2.PLoS One2023
36426404A multicenter study of clinical impact of variant of uncertain significance reclassification in breast, ovarian and colorectal cancer susceptibility genes.Cancer Med2023
36600593Optimising clinical care through <i>CDH1</i>-specific germline variant curation: improvement of clinical assertions and updated curation guidelines.J Med Genet2023
34923710Harmonizing variant classification for return of results in the All of Us Research Program.Hum Mutat2022
35365779Implementation of pharmacogenomic clinical decision support for health systems: a cost-utility analysis.Pharmacogenomics J2022
35628017Socioeconomic Status and Interest in Genetic Testing in a US-Based Sample.Healthcare (Basel)2022
33864888Molecular diagnosis of childhood immune dysregulation, polyendocrinopathy, and enteropathy, and implications for clinical management.J Allergy Clin Immunol2022
35225377An algorithm for optimal testing in co-segregation analysis.Hum Mutat2022
34863587Inherited TP53 Variants and Risk of Prostate Cancer.Eur Urol2022
32579152Relationship between genetic knowledge and familial communication of CRC risk and intent to communicate CRCP genetic information: insights from FamilyTalk eMERGE III.Transl Behav Med2021
33848333Multiplexing mutation rate assessment: determining pathogenicity of Msh2 variants in Saccharomyces cerevisiae.Genetics2021
33591484The FamilyTalk randomized controlled trial: patient-reported outcomes in clinical genetic sequencing for colorectal cancer.Cancer Causes Control2021
34793697Closing the gap: Systematic integration of multiplexed functional data resolves variants of uncertain significance in BRCA1, TP53, and PTEN.Am J Hum Genet2021
34250417Prospective Statewide Study of Universal Screening for Hereditary Colorectal Cancer: The Ohio Colorectal Cancer Prevention Initiative.JCO Precis Oncol2021
34007000One in seven pathogenic variants can be challenging to detect by NGS: an analysis of 450,000 patients with implications for clinical sensitivity and genetic test implementation.Genet Med2021
33979874Infobuttons for Genomic Medicine: Requirements and Barriers.Appl Clin Inform2021
33373667Design of a study to implement population-based risk assessment for hereditary cancer genetic testing in primary care.Contemp Clin Trials2021
33455827What improves the likelihood of people receiving genetic test results communicating to their families about genetic risk?Patient Educ Couns2021
32997669Effects of germline and somatic events in candidate BRCA-like genes on breast-tumor signatures.PLoS One2020
31916645Exploring relatives' perceptions of participation, ethics, and communication in a patient-driven study for hereditary cancer variant reclassification.J Genet Couns2020
31911673Systematic misclassification of missense variants in BRCA1 and BRCA2 "coldspots".Genet Med2020
32886903Complexities of Next-Generation Sequencing in Solid Tumors: Case Studies.J Natl Compr Canc Netw2020
32686686Landscape of somatic single nucleotide variants and indels in colorectal cancer and impact on survival.Nat Commun2020
30636062Patients' perspectives of variants of uncertain significance and strategies for uncertainty management.J Genet Couns2019
31843900Characterization of splice-altering mutations in inherited predisposition to cancer.Proc Natl Acad Sci U S A2019
31862013Recommendations for the collection and use of multiplexed functional data for clinical variant interpretation.Genome Med2019
30027524Experiences of patients seeking to participate in variant of uncertain significance reclassification research.J Community Genet2019
30019097Modified capture-recapture estimates of the number of families with Lynch syndrome in Central Ohio.Fam Cancer2019
31246251Comparison of CDH1 Penetrance Estimates in Clinically Ascertained Families vs Families Ascertained for Multiple Gastric Cancers.JAMA Oncol2019
31296927Exploring the effect of ascertainment bias on genetic studies that use clinical pedigrees.Eur J Hum Genet2019
31317629Insurance coverage does not predict outcomes of genetic testing: The search for meaning in payer decisions for germline cancer tests.J Genet Couns2019
31400517Clinical exome sequencing vs. usual care for hereditary colorectal cancer diagnosis: A pilot comparative effectiveness study.Contemp Clin Trials2019
31036281Technical, Biological, and Systems Barriers for Molecular Clinical Decision Support.Clin Lab Med2019
31163102Patient goals, motivations, and attitudes in a patient-driven variant reclassification study.J Genet Couns2019
31075532Incorporating user feedback in the design of a genetics analysis tool: A two-part approach.J Biomed Inform2019
30374176Outcomes of 92 patient-driven family studies for reclassification of variants of uncertain significance.Genet Med2019
28695303A comparison of cosegregation analysis methods for the clinical setting.Fam Cancer2018
32913991Postmortem Somatic Sequencing of Tumors From Patients With Suspected Lynch Syndrome Has Clinical Utility for Surviving Relatives.JCO Precis Oncol2018
29887214Using Somatic Mutations from Tumors to Classify Variants in Mismatch Repair Genes.Am J Hum Genet2018
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Collaborators

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