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Author Details

Robert Kralovics
Medical University of Vienna
1995
132
52
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36347013Genetic basis and molecular profiling in myeloproliferative neoplasms.Blood2023
36814396Phenotypic characterization of disease-initiating stem cells in JAK2- or CALR-mutated myeloproliferative neoplasms.Am J Hematol2023
35015307PD-L1 overexpression correlates with JAK2-V617F mutational burden and is associated with 9p uniparental disomy in myeloproliferative neoplasms.Am J Hematol2022
36053947Co-expression of mutated Jak2 and Calr enhances myeloproliferative phenotype in mice without loss of stem cell fitness.Am J Hematol2022
34983928Author Correction: Genome-wide association study identifies susceptibility loci for acute myeloid leukemia.Nat Commun2022
32814349Germline genetic factors influence the outcome of interferon-α therapy in polycythemia vera.Blood2021
33623882Precision Medicine in Hematology 2021: Definitions, Tools, Perspectives, and Open Questions.Hemasphere2021
33761144Hematopoietic expression of a chimeric murine-human CALR oncoprotein allows the assessment of anti-CALR antibody immunotherapies in vivo.Am J Hematol2021
33707020Multimodality imaging beyond CLEM: Showcases of combined in-vivo preclinical imaging and ex-vivo microscopy to detect murine mural vascular lesions.Methods Cell Biol2021
34333533High-throughput drug screening identifies the ATR-CHK1 pathway as a therapeutic vulnerability of CALR mutated hematopoietic cells.Blood Cancer J2021
332415585-Arylidene-2-(4-hydroxyphenyl)aminothiazol-4(5H)-ones with selective inhibitory activity against some leukemia cell lines.Arch Pharm (Weinheim)2021
33202418Hematoxylin binds to mutant calreticulin and disrupts its abnormal interaction with thrombopoietin receptor.Blood2021
31123029High activation of STAT5A drives peripheral T-cell lymphoma and leukemia.Haematologica2020
32014125Ropeginterferon alfa-2b versus standard therapy for polycythaemia vera (PROUD-PV and CONTINUATION-PV): a randomised, non-inferiority, phase 3 trial and its extension study.Lancet Haematol2020
31741139Progress in elucidation of molecular pathophysiology of myeloproliferative neoplasms and its application to therapeutic decisions.Int J Hematol2020
33134869Ropeginterferon Alfa-2b: Efficacy and Safety in Different Age Groups.Hemasphere2020
32824053Myelomonocytic Skewing In Vitro Discriminates Subgroups of Patients with Myelofibrosis with A Different Phenotype, A Different Mutational Profile and Different Prognosis.Cancers (Basel)2020
32326377STAT5 is Expressed in CD34[+]/CD38[-] Stem Cells and Serves as a Potential Molecular Target in Ph-Negative Myeloproliferative Neoplasms.Cancers (Basel)2020
31471561Knock-in of murine Calr del52 induces essential thrombocythemia with slow-rising dominance in mice and reveals key role of Calr exon 9 in cardiac development.Leukemia2020
30635286CDK6 coordinates <i>JAK2</i> <sup><i>V617F</i></sup> mutant MPN via NF-κB and apoptotic networks.Blood2019
31064751Mutational landscape of the transcriptome offers putative targets for immunotherapy of myeloproliferative neoplasms.Blood2019
31133746MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation.Nat Genet2019
30902807Calreticulin mutants as oncogenic rogue chaperones for TpoR and traffic-defective pathogenic TpoR mutants.Blood2019
30535576International external quality assurance of JAK2 V617F quantification.Ann Hematol2019
28744014Low-burden TP53 mutations in chronic phase of myeloproliferative neoplasms: association with age, hydroxyurea administration, disease type and JAK2 mutational status.Leukemia2018
30074634Precision immunotherapy, mutational landscape, and emerging tools to optimize clinical outcomes in patients with classical myeloproliferative neoplasms.Hematol Oncol2018
29907599Aggressive B-cell lymphomas in patients with myelofibrosis receiving JAK1/2 inhibitor therapy.Blood2018
30287855Ropeginterferon alpha-2b targets JAK2V617F-positive polycythemia vera cells in vitro and in vivo.Blood Cancer J2018
30333916Correction: The ratio of STAT1 to STAT3 expression is a determinant of colorectal cancer growth.Oncotarget2018
30442766LZTR1 is a regulator of RAS ubiquitination and signaling.Science2018
29472722Chromothripsis in acute myeloid leukemia: biological features and impact on survival.Leukemia2018
27432009Impact of white blood cell counts at diagnosis and during follow-up in patients with essential thrombocythaemia and prefibrotic primary myelofibrosis.Br J Haematol2017
29153976Image-based ex-vivo drug screening for patients with aggressive haematological malignancies: interim results from a single-arm, open-label, pilot study.Lancet Haematol2017
29089570Parallel genome-wide screens identify synthetic viable interactions between the BLM helicase complex and Fanconi anemia.Nat Commun2017
28914569Mutations in myeloproliferative neoplasms - their significance and clinical use.Expert Rev Hematol2017
28028029Genetic basis and molecular pathophysiology of classical myeloproliferative neoplasms.Blood2017
26845587Paul Ehrlich (1854-1915) and His Contributions to the Foundation and Birth of Translational Medicine.J Innate Immun2016
28725479A time-resolved molecular map of the macrophage response to VSV infection.NPJ Syst Biol Appl2016
26574608Germline RBBP6 mutations in familial myeloproliferative neoplasms.Blood2016
26423830Whole-exome sequencing identifies novel MPL and JAK2 mutations in triple-negative myeloproliferative neoplasms.Blood2016
26668133Thrombopoietin receptor activation by myeloproliferative neoplasm associated calreticulin mutants.Blood2016
26608331Calreticulin mutants in mice induce an MPL-dependent thrombocytosis with frequent progression to myelofibrosis.Blood2016
27149854A Comprehensive Analysis of the Dynamic Response to Aphidicolin-Mediated Replication Stress Uncovers Targets for ATM and ATMIN.Cell Rep2016
27389715Cooperation of germ line JAK2 mutations E846D and R1063H in hereditary erythrocytosis with megakaryocytic atypia.Blood2016
27191495The ratio of STAT1 to STAT3 expression is a determinant of colorectal cancer growth.Oncotarget2016
27216218LNK mutations in familial myeloproliferative neoplasms.Blood2016
27401344Loss of Ezh2 synergizes with JAK2-V617F in initiating myeloproliferative neoplasms and promoting myelofibrosis.J Exp Med2016
275690998p11 myeloproliferative syndrome: diagnostic challenges and pitfalls.J BUON2016
26987905Pathologic activation of thrombopoietin receptor and JAK2-STAT5 pathway by frameshift mutants of mouse calreticulin.Leukemia2016
26883579Thrombopoietin receptor is required for the oncogenic function of CALR mutants.Leukemia2016
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Collaborators

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
Co-authored papers 14
National Cancer Institute, National Institutes of Health
Co-authored papers 11
Karolinska Institutet.
Co-authored papers 10
CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
Co-authored papers 9
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Co-authored papers 9
Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna
Co-authored papers 7
Taussig Cancer Institute, Cleveland Clinic
Co-authored papers 6
Center for Cancer Research, Comprehensive Cancer Centre, Medical University of Vienna
Co-authored papers 4
University of Pavia & S. Matteo Hospital
Co-authored papers 4
CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
Co-authored papers 3
CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
Co-authored papers 2
Netherlands Cancer Institute
Co-authored papers 2
German Research Center for Environmental Health, Institute of Genetic Epidemiology
Co-authored papers 2
CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
Co-authored papers 2
University of Utah Huntsman Cancer Institute
Co-authored papers 2
CeMM Research Centre for Molecular Medicine of the Austrian Academy of Sciences
Co-authored papers 1
The Ohio State University
Co-authored papers 1
Lille University Hospital, INSERM UMR-S7, CNRS UMR9020, Lille University.
Co-authored papers 1
Stanford University School of Medicine
Co-authored papers 1
CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
Co-authored papers 1
Co-authored papers 1
CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
Co-authored papers 1
Saint-Louis Hospital
Co-authored papers 1
Institute of Physiological Chemistry, University of Marburg 35032 Marburg Germany .
Co-authored papers 1
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Co-authored papers 1
CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
Co-authored papers 1
Translational and Clinical Research Institute, Newcastle University
Co-authored papers 1
University Hospital TU Dresden
Co-authored papers 1
German Research Center for Cardiovascular Disease (DZHK)
Co-authored papers 1
Co-authored papers 1