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Author Details

Diana R Tomchick
University of Texas Southwestern Medical Center
1993
112
52
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36894018Molecular determinants for differential activation of the bile acid receptor from the pathogen Vibrio parahaemolyticus.J Biol Chem2023
37875561Structural insights for selective disruption of Beclin 1 binding to Bcl-2.Commun Biol2023
34176438Structure and dynamics of major histocompatibility class Ib molecule H2-M3 complexed with mitochondrial-derived peptides.J Biomol Struct Dyn2022
36512492Repurposed dihydroorotate dehydrogenase inhibitors with efficacy against drug-resistant Acinetobacter baumannii.Proc Natl Acad Sci U S A2022
33277357Alternative pathways utilize or circumvent putrescine for biosynthesis of putrescine-containing rhizoferrin.J Biol Chem2021
33876936Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series.J Med Chem2021
33927055Dynamic remodeling of host membranes by self-organizing bacterial effectors.Science2021
32220963Genetic and structural studies of RABL3 reveal an essential role in lymphoid development and function.Proc Natl Acad Sci U S A2020
32248693Lead Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series for the Treatment of Malaria.J Med Chem2020
32229585A <i>Legionella</i> effector kinase is activated by host inositol hexakisphosphate.J Biol Chem2020
32424347A distinct inhibitory mechanism of the V-ATPase by Vibrio VopQ revealed by cryo-EM.Nat Struct Mol Biol2020
30375858Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265.ACS Infect Dis2019
31522888A Bacterial Effector Mimics a Host HSP90 Client to Undermine Immunity.Cell2019
30712872Molecular Discrimination between Two Conformations of Sphingomyelin in Plasma Membranes.Cell2019
31123136Bacterial pseudokinase catalyzes protein polyglutamylation to inhibit the SidE-family ubiquitin ligases.Science2019
30855230Importin-9 wraps around the H2A-H2B core to act as nuclear importer and histone chaperone.Elife2019
31048915High-resolution cryo-EM structures of the E. coli hemolysin ClyA oligomers.PLoS One2019
30270044Protein AMPylation by an Evolutionarily Conserved Pseudokinase.Cell2018
30197036Trypanosomatid Deoxyhypusine Synthase Activity Is Dependent on Shared Active-Site Complementation between Pseudoenzyme Paralogs.Structure2018
28923929Exceptionally tight membrane-binding may explain the key role of the synaptotagmin-7 C<sub>2</sub>A domain in asynchronous neurotransmitter release.Proc Natl Acad Sci U S A2017
28168761Functional clues from the crystal structure of an orphan periplasmic ligand-binding protein from Treponema pallidum.Protein Sci2017
28177287Mechanistic insights into neurotransmitter release and presynaptic plasticity from the crystal structure of Munc13-1 C<sub>1</sub>C<sub>2</sub>BMUN.Elife2017
29063833SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK.Elife2017
26971492Structural Basis and IP6 Requirement for Pds5-Dependent Cohesin Dynamics.Mol Cell2016
26626129Molecular insights into the enzymatic diversity of flavin-trafficking protein (Ftp; formerly ApbE) in flavoprotein biogenesis in the bacterial periplasm.Microbiologyopen2016
27641613A Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Improved Drug-like Properties for Treatment and Prevention of Malaria.ACS Infect Dis2016
27791135Crystal structure of the cohesin loader Scc2 and insight into cohesinopathy.Proc Natl Acad Sci U S A2016
27977001Relief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralog.Elife2016
27377244Bile salt receptor complex activates a pathogenic type III secretion system.Elife2016
27185916Phosphorylation of spore coat proteins by a family of atypical protein kinases.Proc Natl Acad Sci U S A2016
27127993Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity.J Med Chem2016
26878348Pathogenic C9ORF72 Antisense Repeat RNA Forms a Double Helix with Tandem C:C Mismatches.Biochemistry2016
25627682Coiled-coil coactivators play a structural role mediating interactions in hypoxia-inducible factor heterodimerization.J Biol Chem2015
26180101A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria.Sci Transl Med2015
25944861Evidence for Posttranslational Protein Flavinylation in the Syphilis Spirochete Treponema pallidum: Structural and Biochemical Insights from the Catalytic Core of a Periplasmic Flavin-Trafficking Protein.mBio2015
26030874Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solution.Nat Struct Mol Biol2015
24373768Structure and Ca²⁺-binding properties of the tandem C⿿ domains of E-Syt2.Structure2014
25468971Full-length structure of a monomeric histidine kinase reveals basis for sensory regulation.Proc Natl Acad Sci U S A2014
25308863Substrate-specific activation of the mitotic kinase Bub1 through intramolecular autophosphorylation and kinetochore targeting.Structure2014
25173175Structure of cohesin subcomplex pinpoints direct shugoshin-Wapl antagonism in centromeric cohesion.Nat Struct Mol Biol2014
24842998Re-examining how complexin inhibits neurotransmitter release.Elife2014
24842928Identification of lysine residues in the Borrelia burgdorferi DbpA adhesin required for murine infection.Infect Immun2014
23447540The TP0796 lipoprotein of Treponema pallidum is a bimetal-dependent FAD pyrophosphatase with a potential role in flavin homeostasis.J Biol Chem2013
24120140The bacterial effector VopL organizes actin into filament-like structures.Cell2013
23972470Structural basis for autoactivation of human Mst2 kinase and its regulation by RASSF5.Structure2013
23776203Structure of the human cohesin inhibitor Wapl.Proc Natl Acad Sci U S A2013
22355143Autoinhibition of Mint1 adaptor protein regulates amyloid precursor protein binding and processing.Proc Natl Acad Sci U S A2012
23091007Structural analysis of human Cdc20 supports multisite degron recognition by APC/C.Proc Natl Acad Sci U S A2012
23042995Biophysical and bioinformatic analyses implicate the Treponema pallidum Tp34 lipoprotein (Tp0971) in transition metal homeostasis.J Bacteriol2012
22504226Structural and thermodynamic characterization of the interaction between two periplasmic Treponema pallidum lipoproteins that are components of a TPR-protein-associated TRAP transporter (TPAT).J Mol Biol2012
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Collaborators

Chad A Brautigam
UT Southwestern Medical Center
Co-authored papers 29
Josep Rizo
University of Texas Southwestern Medical Center
Co-authored papers 16
Xuelian Luo
University of Texas Southwestern Medical Center
Co-authored papers 10
Michael K Rosen
UT Southwestern Medical Center
Co-authored papers 7
Krzysztof Paw??owski
Kashubian Center for Heart and Vascular Diseases in Wejherowo, Pomeranian Hospitals
Co-authored papers 6
Kevin H Gardner
CUNY Advanced Science Research Center
Co-authored papers 4
Jenny Jiou
University of Texas Southwestern Medical Center
Co-authored papers 2
Wladek Minor
University of Virginia
Co-authored papers 2
Ivan Rayment
College of Agricultural and Life Sciences, University of Wisconsin-Madison
Co-authored papers 2
Abhilash Padavannil
University of California davis
Co-authored papers 1
Andrej Sali (CM4AI)
University of California San Francisco
Co-authored papers 1
Jen Liou
Co-authored papers 1
Sheena D'Arcy
The University of Texas at Dallas
Co-authored papers 1
Xue Zhong
Co-authored papers 1
Kevan M Shokat
University of California San Francisco
Co-authored papers 1
Ma??gorzata Dudkiewicz
Warsaw University of Life Sciences
Co-authored papers 1
Prithwijit Sarkar
University of Texas at Dallas
Co-authored papers 1
Alpay B Seven
Stanford University School of Medicine
Co-authored papers 1
Michele Vendruscolo
University of Cambridge
Co-authored papers 1
Alexandre M J J Bonvin
Bijvoet Center for Biomolecular Research, Utrecht University
Co-authored papers 1
Sangeeta N Bhatia
Brigham and Women's Hospital and Harvard Medical School
Co-authored papers 1
Seung Joong Kim
Korea Advanced Institute of Science and Technology (KAIST)
Co-authored papers 1
Daniel D Billadeau
Co-authored papers 1
Gaya K Amarasinghe
Washington University School of Medicine at St. Louis
Co-authored papers 1
Frank M Raushel
Texas A&M University, College Station
Co-authored papers 1
Tolga Cagatay
University of Texas Southwestern Medical Center
Co-authored papers 1
Jack E Dixon
University of California
Co-authored papers 1
Philip J Rosenthal
University of California at San Francisco
Co-authored papers 1
Andrei L Osterman
Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 1
Philip A Cole
Brigham and Women's Hospital, Blavatnik Institute, Harvard Medical School
Co-authored papers 1
Release 1.2