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Author Details

John Le Quesne
Beatson Cancer Research Institute, University of Glasgow
1998
65
32
PMIDPaper TitleJournal TitlePublished Year
36727461eIF4A1-dependent mRNAs employ purine-rich 5'UTR sequences to activate localised eIF4A1-unwinding through eIF4A1-multimerisation to facilitate translation.Nucleic Acids Res2023
37672979Self-supervised deep learning for highly efficient spatial immunophenotyping.EBioMedicine2023
37476187Protein expression of S100A2 reveals it association with patient prognosis and immune infiltration profile in colorectal cancer.J Cancer2023
36853169Spatial Positioning of Immune Hotspots Reflects the Interplay between B and T Cells in Lung Squamous Cell Carcinoma.Cancer Res2023
36735782Spatial regulation of the glycocalyx component podocalyxin is a switch for prometastatic function.Sci Adv2023
36503176Defining Morphologic Features of Invasion in Pulmonary Nonmucinous Adenocarcinoma With Lepidic Growth: A Proposal by the International Association for the Study of Lung Cancer Pathology Committee.J Thorac Oncol2023
36702176Absent expansion of AXIN2+ hepatocytes and altered physiology in Axin2CreERT2 mice challenges the role of pericentral hepatocytes in homeostatic liver regeneration.J Hepatol2023
34779486Statins mediate anti- and pro-tumourigenic functions by remodelling the tumour microenvironment.Dis Model Mech2022
32895961Neuropathological findings in two patients with fatal COVID-19.Neuropathol Appl Neurobiol2021
33795785Transcriptional perturbation of protein arginine methyltransferase-5 exhibits MTAP-selective oncosuppression.Sci Rep2021
33627632Mutant p53 promotes RCP-dependent chemoresistance coinciding with increased delivery of P-glycoprotein to the plasma membrane.Cell Death Dis2021
33741915Clonal architecture in mesothelioma is prognostic and shapes the tumour microenvironment.Nat Commun2021
34389715The pathogenesis of mesothelioma is driven by a dysregulated translatome.Nat Commun2021
34099722Author Correction: Clonal architecture in mesothelioma is prognostic and shapes the tumour microenvironment.Nat Commun2021
34337530Analysis of Prostate Cancer Tumor Microenvironment Identifies Reduced Stromal CD4 Effector T-cell Infiltration in Tumors with Pelvic Nodal Metastasis.Eur Urol Open Sci2021
34330898The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer.Nat Commun2021
34021911SOX9 has distinct roles in the formation and progression of different non-small cell lung cancer histotypes.J Pathol2021
33328217MNK Inhibition Sensitizes <i>KRAS</i>-Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression.Cancer Discov2021
33155719Inclusion of multiple high-risk histopathological criteria improves the prediction of adjuvant chemotherapy efficacy in lung adenocarcinoma.Histopathology2021
32394387Automated Co-in Situ Hybridization and Immunofluorescence Using Archival Tumor Tissue.Methods Mol Biol2020
33160409Microfilaria-dependent thoracic pathology associated with eosinophilic and fibrotic polyps in filaria-infected rodents.Parasit Vectors2020
33237744Nanomolar Protein-Protein Interaction Monitoring with a Label-Free Protein-Probe Technique.Anal Chem2020
32441764Repositioning PARP inhibitors for SARS-CoV-2 infection(COVID-19); a new multi-pronged therapy for acute respiratory distress syndrome?Br J Pharmacol2020
32333813Presence of pleomorphic features but not growth patterns improves prognostic stratification of epithelioid malignant pleural mesothelioma by 2-tier nuclear grade.Histopathology2020
32129476The path to a better biomarker: application of a risk management framework for the implementation of PD-L1 and TILs as immuno-oncology biomarkers in breast cancer clinical trials and daily practice.J Pathol2020
30932019In situ growth in early lung adenocarcinoma may represent precursor growth or invasive clone outgrowth-a clinically relevant distinction.Mod Pathol2019
31888698mRNA structural elements immediately upstream of the start codon dictate dependence upon eIF4A helicase activity.Genome Biol2019
31791371eIF4A2 drives repression of translation at initiation by Ccr4-Not through purine-rich motifs in the 5'UTR.Genome Biol2019
32190817Reduced Protumorigenic Tumor-Associated Macrophages With Statin Use in Premalignant Human Lung Adenocarcinoma.JNCI Cancer Spectr2019
31469835IL-4 receptor dependent expansion of lung CD169+ macrophages in microfilaria-driven inflammation.PLoS Negl Trop Dis2019
29345617Loss of functional BAP1 augments sensitivity to TRAIL in cancer cells.Elife2018
30076358Genomic instability in mutant p53 cancer cells upon entotic engulfment.Nat Commun2018
30154405Publisher Correction: Genomic instability in mutant p53 cancer cells upon entotic engulfment.Nat Commun2018
30127402BCL11A interacts with SOX2 to control the expression of epigenetic regulators in lung squamous carcinoma.Nat Commun2018
29925636The ERBB network facilitates KRAS-driven lung tumorigenesis.Sci Transl Med2018
30381462p53 mutants cooperate with HIF-1 in transcriptional regulation of extracellular matrix components to promote tumor progression.Proc Natl Acad Sci U S A2018
29471358eIF4A alleviates the translational repression mediated by classical secondary structures more than by G-quadruplexes.Nucleic Acids Res2018
29258292Corrigendum: Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution.Nature2018
29112861Long-Fiber Carbon Nanotubes Replicate Asbestos-Induced Mesothelioma with Disruption of the Tumor Suppressor Gene Cdkn2a (Ink4a/Arf).Curr Biol2017
28445469Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution.Nature2017
28445112Tracking the Evolution of Non-Small-Cell Lung Cancer.N Engl J Med2017
28202521<i>Ex Vivo</i> Explant Cultures of Non-Small Cell Lung Carcinoma Enable Evaluation of Primary Tumor Responses to Anticancer Therapy.Cancer Res2017
26067143Decline in Antigenicity of Tumor Markers by Storage Time Using Pathology Sections Cut From Tissue Microarrays.Appl Immunohistochem Mol Morphol2016
27598680Challenges in molecular testing in non-small-cell lung cancer patients with advanced disease.Lancet2016
26096930Resistance to HSP90 inhibition involving loss of MCL1 addiction.Oncogene2016
25611378The malignant phenotype in breast cancer is driven by eIF4A1-mediated changes in the translational landscape.Cell Death Dis2015
26614665Translational dysregulation in cancer: eIF4A isoforms and sequence determinants of eIF4A dependence.Biochem Soc Trans2015
25959953The molecular approach to diagnosis in lung cancer.Br J Hosp Med (Lond)2015
25741597Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity.Cell Death Dis2015
24787965A comparison of immunohistochemical assays and FISH in detecting the ALK translocation in diagnostic histological and cytological lung tumor material.J Thorac Oncol2014
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Wei Yang
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Oscar M Rueda
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David L Rimm
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David Ron
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Graham G Giles
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Qi Zhang
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