Author details

Full Name

Roi Isaac

Affiliation

ORCID

Career Start Year

2007

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37492105	Human gain-of-function variants in HNF1A confer protection from diabetes but independently increase hepatic secretion of atherogenic lipoproteins.	Cell Genom	2023
35472707	HIF-2Î± Preserves Mitochondrial Activity and Glucose Sensing in Compensating Î²-Cells in Obesity.		2022
36304109	A seven-transmembrane protein-TM7SF3, resides in nuclear speckles and regulates alternative splicing.	iScience	2022
35637408	Cancer-cell-secreted extracellular vesicles suppress insulin secretion through miR-122 to impair systemic glucose homeostasis and contribute to tumour growth.	Nat Cell Biol	2022
34489604	Hepatocyte-derived exosomes from early onset obese mice promote insulin sensitivity through miR-3075.	Nat Metab	2021
34496230	Exosomes as mediators of intercellular crosstalk in metabolism.	Cell Metab	2021
31708444	TAZ Is a Negative Regulator of PPARÎ³ Activity in Adipocytes and TAZ Deletion Improves Insulin Sensitivity and Glucose Tolerance.	Cell Metab	2020
32355198	The Animal Lectin Galectin-8 Promotes Cytokine Expression and Metastatic Tumor Growth in Mice.	Scientific Reports	2020
30595478	Expansion of Islet-Resident Macrophages Leads to Inflammation Affecting Î² Cell Proliferation and Function in Obesity.	Cell Metab	2019
31611602	Adipocyte PU.1 knockout promotes insulin sensitivity in HFD-fed obese mice.	Scientific Reports	2019
29572328	Selective serotonin reuptake inhibitors (SSRIs) inhibit insulin secretion and action in pancreatic Î² cells.	Journal of Biological Chemistry	2018
27740623	TM7SF3, a novel p53-regulated homeostatic factor, attenuates cellular stress and the subsequent induction of the unfolded protein response.	Cell Death and Differentiation	2017
28424159	Prolonged Elimination of Negative Feedback Control Mechanisms Along the Insulin Signaling Pathway Impairs Î²-Cell Function In Vivo.		2017
27411561	Prolonged insulin treatment sensitizes apoptosis pathways in pancreatic Î² cells.	Journal of Endocrinology	2016
26319551	Nedd4 family interacting protein 1 (Ndfip1) promotes death of pancreatic beta cells.	Biochemical and Biophysical Research Communications	2015
23515685	Otubain 2 is a novel promoter of beta cell survival as revealed by siRNA high-throughput screens of human pancreatic islets.	Diabetologia	2013
23275337	Selective serotonin reuptake inhibitors (SSRIs) inhibit insulin secretion and action in pancreatic Î² cells.	Journal of Biological Chemistry	2013
21853325	An siRNA screen identifies transmembrane 7 superfamily member 3 (TM7SF3), a seven transmembrane orphan receptor, as an inhibitor of cytokine-induced death of pancreatic beta cells.	Diabetologia	2011
20547979	Elimination of negative feedback control mechanisms along the insulin signaling pathway improves beta-cell function under stress.		2010
17728140	Antidepressants induce cellular insulin resistance by activation of IRS-1 kinases.	Molecular and Cellular Neurosciences	2007