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Author Details

Alan Saghatelian
Salk Institute for Biological Studies
2000
152
59
Emma Lundberg (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36266352A class of anti-inflammatory lipids decrease with aging in the central nervous system.Nat Chem Biol2023
37084731Proteomic discovery of chemical probes that perturb protein complexes in human cells.Mol Cell2023
36899004The TINCR ubiquitin-like microprotein is a tumor suppressor in squamous cell carcinoma.Nat Commun2023
36658336Correction: Mitochondrial DNA variation in Alzheimer's disease reveals a unique microprotein called SHMOOSE.Mol Psychiatry2023
34986332FGF1 and insulin control lipolysis by convergent pathways.Cell Metab2022
35676490ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids.Nature2022
35831657Standardized annotation of translated open reading frames.Nat Biotechnol2022
35793637Diet and feeding pattern modulate diurnal dynamics of the ileal microbiome and transcriptome.Cell Rep2022
35940205Autoantibody mimicry of hormone action at the thyrotropin receptor.Nature2022
35015730Inhibition of ceramide accumulation in AdipoR1-/- mice increases photoreceptor survival and improves vision.JCI Insight2022
35188179µProteInS-a proteogenomics pipeline for finding novel bacterial microproteins encoded by small ORFs.Bioinformatics2022
33468658A short ORF-encoded transcriptional regulator.Proc Natl Acad Sci U S A2021
34418413Distinct biological activities of isomers from several families of branched fatty acid esters of hydroxy fatty acids (FAHFAs).J Lipid Res2021
34132745Nano-scale resolution of native retinal rod disk membranes reveals differences in lipid composition.J Cell Biol2021
32297516Insights into GLP-1 Receptor Activation with a Nonpeptide Agonist.Biochemistry2020
31943697The lipid elongation enzyme ELOVL2 is a molecular regulator of aging in the retina.Aging Cell2020
31819274Accurate annotation of human protein-coding small open reading frames.Nat Chem Biol2020
33276584Elovl2 Is Required for Robust Visual Function in Zebrafish.Cells2020
32946756Networking in Circulation: Lipoproteins, PM20D1, and N-acyl Amino Acid Bioactivity.Cell Chem Biol2020
32915949FIT2 is an acyl-coenzyme A diphosphatase crucial for endoplasmic reticulum homeostasis.J Cell Biol2020
32788725Serine restriction alters sphingolipid diversity to constrain tumour growth.Nature2020
32152231AIG1 and ADTRP are endogenous hydrolases of fatty acid esters of hydroxy fatty acids (FAHFAs) in mice.J Biol Chem2020
32444367Antioxidant Effects of N-Acetylcysteine Prevent Programmed Metabolic Disease in Mice.Diabetes2020
32541956Directed remodeling of the mouse gut microbiome inhibits the development of atherosclerosis.Nat Biotechnol2020
30605676Genetic Liver-Specific AMPK Activation Protects against Diet-Induced Obesity and NAFLD.Cell Rep2019
31383375Substrate-Selective Enzyme Inhibitors.Trends Pharmacol Sci2019
31380811PAHSAs attenuate immune responses and promote β cell survival in autoimmune diabetic mice.J Clin Invest2019
31545060Stereochemistry of Linoleic Acid Esters of Hydroxy Linoleic Acids.Org Lett2019
31449056PAHSAs enhance hepatic and systemic insulin sensitivity through direct and indirect mechanisms.J Clin Invest2019
30988370Synthesis of chemically edited derivatives of the endogenous regulator of inflammation 9-PAHSA.J Antibiot (Tokyo)2019
31152059Linoleic acid esters of hydroxy linoleic acids are anti-inflammatory lipids found in plants and mammals.J Biol Chem2019
31056915Discovery of FAHFA-Containing Triacylglycerols and Their Metabolic Regulation.J Am Chem Soc2019
30724555A Hidden ORF Reveals an Immune Protector.Biochemistry2019
30819820CDK12 phosphorylates 4E-BP1 to enable mTORC1-dependent translation and mitotic genome stability.Genes Dev2019
29352135Blocking Zika virus vertical transmission.Sci Rep2018
29867187Author Correction: Blocking Zika virus vertical transmission.Sci Rep2018
30215512MIEF1 Microprotein Regulates Mitochondrial Translation.Biochemistry2018
30030441Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism.Nat Commun2018
30244974Methodological Issues in Studying PAHSA Biology: Masking PAHSA Effects.Cell Metab2018
30415582Small, but mighty? Searching for human microproteins and their potential for understanding health and disease.Expert Rev Proteomics2018
29584760The influence of transcript assembly on the proteogenomics discovery of microproteins.PLoS One2018
29578702Faster Protocol for Endogenous Fatty Acid Esters of Hydroxy Fatty Acid (FAHFA) Measurements.Anal Chem2018
29443976How many human proteoforms are there?Nat Chem Biol2018
29414786The serine protease HtrA1 contributes to the formation of an extracellular 25-kDa apolipoprotein E fragment that stimulates neuritogenesis.J Biol Chem2018
29414687Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis.Cell Metab2018
29320480Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence.Nature2018
27918561A human microprotein that interacts with the mRNA decapping complex.Nat Chem Biol2017
28089566Metformin Inhibits Hepatic mTORC1 Signaling via Dose-Dependent Mechanisms Involving AMPK and the TSC Complex.Cell Metab2017
28350171Stereochemistry of Endogenous Palmitic Acid Ester of 9-Hydroxystearic Acid and Relevance of Absolute Configuration to Regulation.J Am Chem Soc2017
28240264Overexpressing the novel autocrine/endocrine adipokine WISP2 induces hyperplasia of the heart, white and brown adipose tissues and prevents insulin resistance.Sci Rep2017
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Collaborators

Benjamin F Cravatt
Scripps Research Institute
Co-authored papers 22
Sarah A Slavoff
Yale University
Co-authored papers 7
Bogdan Budnik
Co-authored papers 4
Satchidananda Panda
The Salk Institute for Biological Studies
Co-authored papers 4
Martina Wallace
University College Dublin
Co-authored papers 3
Ronald M Evans
Co-authored papers 3
Dorota Skowronska-Krawczyk
Center for Translational Vision Research
Co-authored papers 3
Christian M Metallo
Massachusetts Institute of Technology
Co-authored papers 3
Amandine Chaix
University of Utah
Co-authored papers 3
Irwin Jungreis
Broad Institute of MIT and Harvard
Co-authored papers 3
John R Yates
TheScripps Research Institute
Co-authored papers 3
Christopher Benner
Michigan State University College of Human Medicine
Co-authored papers 3
Forest M White
Massachusetts Institute of Technology
Co-authored papers 3
Manolis Kellis
Massachusetts Institute of Technology
Co-authored papers 3
Alysson R Muotri
Department of Pediatrics/Rady Children's Hospital, University of California San Diego
Co-authored papers 2
Gary Siuzdak
Scripps Center for Metabolomics and Mass Spectrometry, The Scripps Research Institute
Co-authored papers 2
Michael Downes
Howard Hughes Medical Institute, Salk Institute for Biological Studies
Co-authored papers 2
Amir Zarrinpar
Co-authored papers 2
Kevin D Corbett
Co-authored papers 2
Renata Pasqualini
Rutgers Cancer Institute of New Jersey
Co-authored papers 2
Max W Chang
University of California San Diego
Co-authored papers 2
Spencer M Moore
University of Arizona College of Medicine
Co-authored papers 2
Daniel L Chao
Shiley Eye Institute, University of San Diego
Co-authored papers 2
Rob Knight
University of California
Co-authored papers 2
Mehmet G Badur
University of California San Diego
Co-authored papers 2
Daniel J Rader
Co-authored papers 2
Siddhesh S Kamat
Indian Institute of Science Education and Research Pune
Co-authored papers 2
Wadih Arap
Rutgers Cancer Institute of New Jersey
Co-authored papers 2
Simon J Boulton
The Francis Crick Institute
Co-authored papers 1
Josep Rizo
University of Texas Southwestern Medical Center
Co-authored papers 1
Release 1.2