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Author Details

Philip J Scarpace
University of Florida
1973
185
50
PMIDPaper TitleJournal TitlePublished Year
29089334iBAT sympathetic innervation is not required for body weight loss induced by central leptin delivery.Am J Physiol Endocrinol Metab2018
30024775Limiting feeding to the active phase reduces blood pressure without the necessity of caloric reduction or fat mass loss.Am J Physiol Regul Integr Comp Physiol2018
30006298ACE2 activator diminazene aceturate reduces adiposity but preserves lean mass in young and old rats.Exp Gerontol2018
30246441Oestradiol and leptin have separate but additive anorexigenic effects and differentially target fat mass in rats.J Neuroendocrinol2018
28419850Overpressure blast injury-induced oxidative stress and neuroinflammation response in rat frontal cortex and cerebellum.Behav Brain Res2018
29131966Activation of the central melanocortin system in rats persistently reduces body and fat mass independently of caloric reduction.Can J Physiol Pharmacol2018
28006433Intracerebroventricular tempol administration in older rats reduces oxidative stress in the hypothalamus but does not change STAT3 signalling or SIRT1/AMPK pathway.Appl Physiol Nutr Metab2017
29044801Differential physiological responses to central leptin overexpression in male and female rats.J Neuroendocrinol2017
28794174Maternal Western diet age-specifically alters female offspring voluntary physical activity and dopamine- and leptin-related gene expression.FASEB J2017
28521325Effect of High-Salt Diet on Age-Related High Blood Pressure and Hypothalamic Redox Signaling.Pharmacology2017
28051332Activation of the central melanocortin system chronically reduces body mass without the necessity of long-term caloric restriction.Can J Physiol Pharmacol2017
25617379Rapamycin Normalizes Serum Leptin by Alleviating Obesity and Reducing Leptin Synthesis in Aged Rats.J Gerontol A Biol Sci Med Sci2016
27298812Age Impaired endothelium-dependent vasodilation is improved by resveratrol in rat mesenteric arteries.J Exerc Nutrition Biochem2016
27232670Anorexic response to rapamycin does not appear to involve a central mechanism.Clin Exp Pharmacol Physiol2016
27226180High dietary fructose does not exacerbate the detrimental consequences of high fat diet on basilar artery function.J Physiol Pharmacol2016
27040098Protective effects of resveratrol on aging-induced cognitive impairment in rats.Neurobiol Learn Mem2016
27012992Onset of leptin resistance shows temporal differences related to dose or pulsed treatment.Eur J Pharmacol2016
26855373Fructose consumption does not worsen bone deficits resulting from high-fat feeding in young male rats.Bone2016
25617380Rapamycin Versus Intermittent Feeding: Dissociable Effects on Physiological and Behavioral Outcomes When Initiated Early and Late in Life.J Gerontol A Biol Sci Med Sci2016
26104291The functional and structural changes in the basilar artery due to overpressure blast injury.J Cereb Blood Flow Metab2015
26462882Successful aging: Advancing the science of physical independence in older adults.Ageing Res Rev2015
24630519The effects of enalapril and losartan on mechanical ventilation-induced sympathoadrenal activation and oxidative stress in rats.J Surg Res2014
24829407Novel role for tumor-induced expansion of myeloid-derived cells in cancer cachexia.J Immunol2014
24920667Targeted leptin receptor blockade: role of ventral tegmental area and nucleus of the solitary tract leptin receptors in body weight homeostasis.J Endocrinol2014
24907295The effects of aging on the functional and structural properties of the rat basilar artery.Physiol Rep2014
22982569Leptin overexpression in VTA trans-activates the hypothalamus whereas prolonged leptin action in either region cross-desensitizes.Neuropharmacology2013
23570732Overpressure blast-wave induced brain injury elevates oxidative stress in the hypothalamus and catecholamine biosynthesis in the rat adrenal medulla.Neurosci Lett2013
23493533Dietary components in the development of leptin resistance.Adv Nutr2013
21636833Usefulness of preclinical models for assessing the efficacy of late-life interventions for sarcopenia.J Gerontol A Biol Sci Med Sci2012
22115947Simultaneous introduction of a novel high fat diet and wheel running induces anorexia.Physiol Behav2012
20881371The act of voluntary wheel running reverses dietary hyperphagia and increases leptin signaling in ventral tegmental area of aged obese rats.Gerontology2011
21551274Effect of age on high-fat diet-induced hypertension.Am J Physiol Heart Circ Physiol2011
21565854POMC overexpression in the ventral tegmental area ameliorates dietary obesity.J Endocrinol2011
21366729Simultaneous POMC gene transfer to hypothalamus and brainstem increases physical activity, lipolysis and reduces adult-onset obesity.Eur J Neurosci2011
21418711Prevention and reversal of diet-induced leptin resistance with a sugar-free diet despite high fat content.Br J Nutr2011
21059361Region-specific diet-induced and leptin-induced cellular leptin resistance includes the ventral tegmental area in rats.Neuropharmacology2011
20034526Intermittent MTII application evokes repeated anorexia and robust fat and weight loss.Peptides2010
20538045Pro-opiomelanocortin gene transfer to the nucleus of the solitary track but not arcuate nucleus ameliorates chronic diet-induced obesity.Neuroscience2010
20193697Wheel running eliminates high-fat preference and enhances leptin signaling in the ventral tegmental area.Physiol Behav2010
19277011Nigrostriatal rAAV-mediated GDNF overexpression induces robust weight loss in a rat model of age-related obesity.Mol Ther2009
19679649Responses to the cannabinoid receptor-1 antagonist, AM251, are more robust with age and with high-fat feeding.J Endocrinol2009
19726711Central overexpression of leptin antagonist reduces wheel running and underscores importance of endogenous leptin receptor activity in energy homeostasis.Am J Physiol Regul Integr Comp Physiol2009
19713964Effect of high-fat diet feeding on hypothalamic redox signaling and central blood pressure regulation.Hypertens Res2009
19422379The soluble leptin receptor neutralizes leptin-mediated STAT3 signalling and anorexic responses in vivo.Br J Pharmacol2009
19091915Leptin resistance: a prediposing factor for diet-induced obesity.Am J Physiol Regul Integr Comp Physiol2009
18086903Synergy between leptin therapy and a seemingly negligible amount of voluntary wheel running prevents progression of dietary obesity in leptin-resistant rats.Diabetes2008
18703413Fructose-induced leptin resistance exacerbates weight gain in response to subsequent high-fat feeding.Am J Physiol Regul Integr Comp Physiol2008
18596107Prolonged hyperphagia with high-fat feeding contributes to exacerbated weight gain in rats with adult-onset obesity.Am J Physiol Regul Integr Comp Physiol2008
17082312Leptin antagonist reveals an uncoupling between leptin receptor signal transducer and activator of transcription 3 signaling and metabolic responses with central leptin resistance.J Pharmacol Exp Ther2007
17984669Leptin antagonist reverses hypertension caused by leptin overexpression, but fails to normalize obesity-related hypertension.J Hypertens2007
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Collaborators

University of Florida
Co-authored papers 68
American College of Medical Informatics, Department of Veteran Affairs, Harvard University T H Chan School of Public Health, Massachusetts Institute of Technology, The American Society for Clinical Investigation, University of Kentucky, Vanderbilt University Medical Center, Vanderbilt University Medical School
Co-authored papers 51
Malcom Randall Veterans Affairs Medical Center
Co-authored papers 28
University of Alabama at Birmingham
Co-authored papers 19
College of Medicine, University of Central Florida
Co-authored papers 15
University of Florida
Co-authored papers 15
College of Medicine
Co-authored papers 14
and Clinical Center
Co-authored papers 13
University of Florida
Co-authored papers 12
College of Medicine, University of Florida
Co-authored papers 11
52979Koc University
Co-authored papers 11
University of Vermont Larner College of Medicine
Co-authored papers 10
College of Medicine, University of Florida
Co-authored papers 8
University of Florida College of Medicine
Co-authored papers 8
University of Florida, College of Medicine
Co-authored papers 8
and Clinical Center, Department of Veterans Affairs Medical Center
Co-authored papers 7
University of Florida College of Medicine
Co-authored papers 6
University of Florida College of Medicine
Co-authored papers 6
University of Florida Health System
Co-authored papers 6
Education and Clinical Center, Department of Veterans Affairs Medical Center
Co-authored papers 6
University of Florida College of Medicine
Co-authored papers 6
University of Florida
Co-authored papers 5
The Johns Hopkins University School of Medicine
Co-authored papers 5
College of Medicine, University of Florida
Co-authored papers 4
Florida State University College of Medicine
Co-authored papers 4
Marmara University
Co-authored papers 4
University of Calgary
Co-authored papers 4
Education and Clinical Center, Department of Veterans Affairs Medical Center
Co-authored papers 4
College of Medicine, University of Florida
Co-authored papers 3
Co-authored papers 3