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Author Details

David J Pagliarini
Washington University School of Medicine
2003
84
36
Leah V Schaffer (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37773518Mitochondrial proteome research: the road ahead.Nat Rev Mol Cell Biol2024
37884804Reducing mitochondrial mysteries.Nat Chem Biol2024
38045259Fast and Deep Phosphoproteome Analysis with the Orbitrap Astral Mass Spectrometer.bioRxiv2024
36266351Nitric oxide-driven modifications of lipoic arm inhibit α-ketoacid dehydrogenases.Nat Chem Biol2023
38014142COQ4 is required for the oxidative decarboxylation of the C1 carbon of Coenzyme Q in eukaryotic cells.bioRxiv2023
37833277PPTC7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy.Nat Commun2023
37503166Coenzyme Q <sub>4</sub> is a functional substitute for coenzyme Q <sub>10</sub> and can be targeted to the mitochondria.bioRxiv2023
37813972Hem25p is required for mitochondrial IPP transport in fungi.Nat Cell Biol2023
37425714TOMM40 and TOMM22 of the Translocase Outer Mitochondrial Membrane Complex rescue statin-impaired mitochondrial dynamics, morphology, and mitophagy in skeletal myotubes.bioRxiv2023
36993473Hem25p is a mitochondrial IPP transporter.bioRxiv2023
36739946Aim18p and Aim46p are chalcone isomerase domain-containing mitochondrial hemoproteins in Saccharomyces cerevisiae.J Biol Chem2023
36909604Pptc7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy.bioRxiv2023
36702698Coenzyme Q biochemistry and biosynthesis.Trends Biochem Sci2023
36302899Small-molecule inhibition of the archetypal UbiB protein COQ8.Nat Chem Biol2023
36306796Structure and functionality of a multimeric human COQ7:COQ9 complex.Mol Cell2022
35614220Defining mitochondrial protein functions through deep multiomic profiling.Nature2022
359047982-Propylphenol Allosterically Modulates COQ8A to Enhance ATPase Activity.ACS Chem Biol2022
32719514Classification of T-cell activation via autofluorescence lifetime imaging.Nat Biomed Eng2021
33617230Multi-Omic Single-Shot Technology for Integrated Proteome and Lipidome Analysis.Anal Chem2021
33862086Defining intermediates and redundancies in coenzyme Q precursor biosynthesis.J Biol Chem2021
34888501Prolyl endopeptidase-like is a (thio)esterase involved in mitochondrial respiratory chain function.iScience2021
34214448Loss of C2orf69 defines a fatal autoinflammatory syndrome in humans and zebrafish that evokes a glycogen-storage-associated mitochondriopathy.Am J Hum Genet2021
34038740Loss of C2orf69 defines a fatal autoinflammatory syndrome in humans and zebrafish that evokes a glycogen-storage-associated mitochondriopathy.Am J Hum Genet2021
34362905UbiB proteins regulate cellular CoQ distribution in Saccharomyces cerevisiae.Nat Commun2021
34144036The extensive and functionally uncharacterized mitochondrial phosphoproteome.J Biol Chem2021
32268114Systems Biochemistry Approaches to Defining Mitochondrial Protein Function.Cell Metab2020
31971854Mass spectrometry proteomics reveals a function for mammalian CALCOCO1 in MTOR-regulated selective autophagy.Autophagy2020
31866046Pathogenic Bi-allelic Mutations in NDUFAF8 Cause Leigh Syndrome with an Isolated Complex I Deficiency.Am J Hum Genet2020
33154995Argonaut: A Web Platform for Collaborative Multi-omic Data Visualization and Exploration.Patterns (N Y)2020
33230323Quantitative shotgun proteome analysis by direct infusion.Nat Methods2020
32337771Clinico-Genetic, Imaging and Molecular Delineation of COQ8A-Ataxia: A Multicenter Study of 59 Patients.Ann Neurol2020
30661980An Isoprene Lipid-Binding Protein Promotes Eukaryotic Coenzyme Q Biosynthesis.Mol Cell2019
31673128ADCK3/COQ8A: the choice target of the UbiB protein kinase-like family.Nat Rev Drug Discov2019
32259027Two-stage metabolic remodelling in macrophages in response to lipopolysaccharide and interferon-γ stimulation.Nat Metab2019
31324765Pptc7 is an essential phosphatase for promoting mammalian mitochondrial metabolism and biogenesis.Nat Commun2019
30674579Coenzyme Q biosynthetic proteins assemble in a substrate-dependent manner into domains at ER-mitochondria contacts.J Cell Biol2019
30700550Obesity-dependent CDK1 signaling stimulates mitochondrial respiration at complex I in pancreatic β-cells.J Biol Chem2019
29248374Multi-omics Reveal Specific Targets of the RNA-Binding Protein Puf3p and Its Orchestration of Mitochondrial Biogenesis.Cell Syst2018
29909277Systems Analyses Reveal Physiological Roles and Genetic Regulators of Liver Lipid Species.Cell Syst2018
29909275Genetic Regulation of Plasma Lipid Species and Their Association with Metabolic Phenotypes.Cell Syst2018
30180576Identification and Quantification of Murine Mitochondrial Proteoforms Using an Integrated Top-Down and Intact-Mass Strategy.J Proteome Res2018
29675961A path to the powerhouse: systems-to-structure approaches for studying mitochondrial proteins.Protein Sci2018
29509408DNA Polymerase θ Increases Mutational Rates in Mitochondrial DNA.ACS Chem Biol2018
29198567Conserved Lipid and Small-Molecule Modulation of COQ8 Reveals Regulation of the Ancient Kinase-like UbiB Family.Cell Chem Biol2018
28076776Ptc7p Dephosphorylates Select Mitochondrial Proteins to Enhance Metabolic Function.Cell Rep2017
29220658Multi-omic Mitoprotease Profiling Defines a Role for Oct1p in Coenzyme Q Production.Mol Cell2017
28539364Integrative proteomics and biochemical analyses define Ptc6p as the <i>Saccharomyces cerevisiae</i> pyruvate dehydrogenase phosphatase.J Biol Chem2017
28927698Biochemistry of Mitochondrial Coenzyme Q Biosynthesis.Trends Biochem Sci2017
28553927Erythropoietin signaling regulates heme biosynthesis.Elife2017
26998524Mitochondrial protein hyperacetylation in the failing heart.JCI Insight2016
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Collaborators

Adam Jochem
Morgridge Institute for Research
Co-authored papers 19
Jarred W Rensvold
Washington University School of Medicine
Co-authored papers 11
Jack E Dixon
University of California
Co-authored papers 7
Matteo Dal Peraro
Institute of Bioengineering
Co-authored papers 5
Vamsi K Mootha
Broad Institute of MIT and Harvard
Co-authored papers 4
Robert W Taylor
Newcastle upon Tyne Hospitals NHS Foundation Trust
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Sarah E Calvo
Co-authored papers 3
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Human Genetics and Genome Research Institute, National Research Centre
Co-authored papers 2
James R Lupski
Baylor College of Medicine
Co-authored papers 2
Henry Houlden
Institute of Neurology, University College London (UCL)
Co-authored papers 2
David R Thorburn
Co-authored papers 2
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University of Wisconsin-Madison College of Letters and Sciences
Co-authored papers 2
Patrick J Casey
Co-authored papers 2
H??lya Kayserili
Istanbul University
Co-authored papers 2
Alicia L Richards
University of Wisconsin-Madison
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University of Luxembourg
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Steven A Carr
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Hamdi Mbarek
Vrije Universiteit
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Joseph G Gleeson
University of California
Co-authored papers 2
Rong Xiao
School of Public Health, Capital Medical University
Co-authored papers 2
Natarajan Kannan
University of Georgia
Co-authored papers 2
Sedat I????kay
Gaziantep University
Co-authored papers 2
James L Engel
David Geffen School of Medicine, University of California los angeles
Co-authored papers 1
Nicholas A Clark
Co-authored papers 1
Mario Medvedovic
Co-authored papers 1
Alexandra Durr
Sorbonne University, Paris Brain Institute - ICM, Inserm, CNRS
Co-authored papers 1
Alexander Broomfield
St Mary's Hospital, Manchester University NHS Foundation Trust
Co-authored papers 1
Huang Wang
Bio-X Institutes, Shanghai Jiao Tong University
Co-authored papers 1
Denise M Kirby
Co-authored papers 1
Benjamin A Garcia
University of Pennsylvania
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Release 1.2