Author details

Full Name

Mitchell J Weiss

Affiliation

ORCID

Career Start Year

1972

Papers

210

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37522715	ETV6 represses inflammatory response genes and regulates HSPC function during stress hematopoiesis in mice.	Blood Adv	2023
36413407	An RPS19-edited model for Diamond-Blackfan anemia reveals TP53-dependent impairment of hematopoietic stem cell activity.	JCI Insight	2023
36907613	Gene Therapy and Gene Editing for Î²-Thalassemia.		2023
37339583	Loss of miR-144/451 alleviates Î²-thalassemia by stimulating ULK1-mediated autophagy of free Î±-globin.		2023
37400614	Potent and uniform fetal hemoglobin induction via base editing.	Nat Genet	2023
37069266	Ex vivo prime editing of patient haematopoietic stem cells rescues sickle-cell disease phenotypes after engraftment in mice.		2023
36865281	Multiplex Base Editing to Protect from CD33-Directed Therapy: Implications for Immune and Gene Therapy.		2023
36993312	Genetic regulation of fetal hemoglobin across global populations.	medRxiv	2023
36852088	Forced enhancer-promoter rewiring to alter gene expression in animal models.		2023
35052663	Redox-Regulation of Î±-Globin in Vascular Physiology.	Antioxidants	2022
36302779	Endothelial alpha globin is a nitrite reductase.	Nat Commun	2022
35650318	Publisher Correction: Dual function NFI factors control fetal hemoglobin silencing in adult erythroid cells.	Nature Genetics	2022
35830837	Recent advances in "sickle and niche" research - Tribute to Dr. Paul S Frenette.	Stem Cell Reports	2022
36224385	Activation of Î³-globin expression by hypoxia-inducible factor 1Î±.	Nature	2022
35934593	Effective therapies for sickle cell disease: are we there yet?	Trends in Genetics	2022
35737751	Optimizing haematopoietic stem and progenitor cell apheresis collection from plerixafor-mobilized patients with sickle cell disease.	Br J Haematol	2022
35618846	Dual function NFI factors control fetal hemoglobin silencing in adult erythroid cells.	Nature Genetics	2022
35793591	Limitations of mouse models for sickle cell disease conferred by their human globin transgene configurations.	Dis Model Mech	2022
36459484	Modular UBE2H-CTLH E2-E3 complexes regulate erythroid maturation.	Elife	2022
35021089	SCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia.	Cell Reports	2022
34486392	The role of globins in cardiovascular physiology.	Physiological Reviews	2022
35090172	Disrupting the adult globin promoter alleviates promoter competition and reactivates fetal globin gene expression.	Blood	2022
33301730	ZNF410Â Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression.	Molecular Cell	2021
34180713	RNA-Binding Proteins PCBP1 and PCBP2 Are Critical Determinants of Murine Erythropoiesis.	Molecular and Cellular Biology	2021
34079130	Base editing of haematopoietic stem cells rescues sickle cell disease in mice.	Nature	2021
33855970	Genetic therapies for the first molecular disease.	Journal of Clinical Investigation	2021
33855784	Eltrombopag in children with severe aplastic anemia.	Pediatr Blood Cancer	2021
34283174	A polygenic score for acute vaso-occlusive pain in pediatric sickle cell disease.	Blood Adv	2021
33958780	Single-nucleotide-level mapping of DNA regulatory elements that control fetal hemoglobin expression.	Nature Genetics	2021
33956057	Disease severity impacts plerixafor-mobilized stem cell collection in patients with sickle cell disease.	Blood Adv	2021
33846636	Chromothripsis as an on-target consequence of CRISPR-Cas9 genome editing.	Nature Genetics	2021
33512425	Dynamic CTCF binding directly mediates interactions among cis-regulatory elements essential for hematopoiesis.	Blood	2021
34137022	Generalization of a genetic risk score for time to first albuminuria in children with sickle cell anaemia: SCCRIP cohort study results.	Br J Haematol	2021
34341563	Activation of Î³-globin gene expression by GATA1 and NF-Y in hereditary persistence of fetal hemoglobin.	Nat Genet	2021
33156908	FBXO11-mediated proteolysis of BAHD1 relieves PRC2-dependent transcriptional repression in erythropoiesis.	Blood	2021
32897878	BCL11A enhancer-edited hematopoietic stem cells persist in rhesus monkeys without toxicity.	J Clin Invest	2020
31769130	Systematic integration of GATA transcription factors and epigenomes via IDEAS paints the regulatory landscape of hematopoietic cells.	IUBMB Life	2020
33259127	Integrative proteomics reveals principles of dynamic phosphosignaling networks in human erythropoiesis.	Mol Syst Biol	2020
32983414	Erythropoietin regulation of red blood cell production: from bench to bedside and back.	F1000Res	2020
32915977	A novel algorithm comprehensively characterizes human RH genes using whole-genome sequencing data.	Blood Adv	2020
30995372	Lentiviral Gene Therapy Combined with Low-Dose Busulfan in Infants with SCID-X1.	N Engl J Med	2019
31698466	Genome editing of HBG1 and HBG2 to induce fetal hemoglobin.	Blood Adv	2019
29884903	Mutation-specific signaling profiles and kinase inhibitor sensitivities of juvenile myelomonocytic leukemia revealed by induced pluripotent stem cells.	Leukemia	2019
31303423	Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome.	Cancer Cell	2019
31526763	Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome.	Cancer Cell	2019
30971389	Regulation of gene expression by miR-144/451 during mouse erythropoiesis.	Blood	2019
30890594	Children with sickle cell anemia and APOL1 genetic variants develop albuminuria early in life.	Haematologica	2019
29797644	Sickle Cell Clinical Research and Intervention Program (SCCRIP): A lifespan cohort study for sickle cell disease progression from the pediatric stage into adulthood.	Pediatr Blood Cancer	2018
30559313	Complexities of genetic diagnosis illustrated by an atypical case of congenital hypoplastic anemia.	Cold Spring Harb Mol Case Stud	2018
29884740	Metformin induces FOXO3-dependent fetal hemoglobin production in human primary erythroid cells.	Blood	2018