Author details

Full Name

Alistair M Chalk

Affiliation

ORCID

Career Start Year

2002

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36975179	The phenotype of the most common human ADAR1p150 ZÎ± mutation P193A in mice is partially penetrant.		2023
37275274	Over-expression of ADAR1 in mice does not initiate or accelerate cancer formation .		2023
34464972	Genome-wide screening identifies cell-cycle control as a synthetic lethal pathway with SRSF2P95H mutation.	Blood Adv	2022
36271153	Srsf2 co-operates with loss of TET2 to promote myeloid bias and initiate a chronic myelomonocytic leukemia-like disease in mice.	Leukemia	2022
33786586	The characterization of distinct populations of murine skeletal cells that have different roles in B lymphopoiesis.	Blood	2021
32541670	Hematopoietic stem and progenitor cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia.	Nat Commun	2020
31033705	Defining the functions of adenosine-to-inosine RNA editing through hematology.	Current Opinion in Hematology	2019
31815657	The majority of A-to-I RNA editing is not required for mammalian homeostasis.		2019
29903888	initiates myeloid bias and myelodysplastic/myeloproliferative syndrome from hemopoietic stem cells.	Blood	2018
28874170	Protein recoding by ADAR1-mediated RNA editing is not essential for normal development and homeostasis.		2017
26692549	ADAR1, inosine and the immune sensing system: distinguishing self from non-self.	Wiley interdisciplinary reviews. RNA	2016
27373493	Adenosine-to-inosine RNA editing by ADAR1 is essential for normal murine erythropoiesis.	Exp Hematol	2016
27041566	Increased miR-155-5p and reduced miR-148a-3p contribute to the suppression of osteosarcoma cell death.	Oncogene	2016
27070462	Activation of PTHrP-cAMP-CREB1 signaling following p53 loss is essential for osteosarcoma initiation and maintenance.	eLife	2016
25043296	Knockdown of PTHR1 in osteosarcoma cells decreases invasion and growth and increases tumor differentiation in vivo.	Oncogene	2015
25862761	Systematic Screening Identifies Dual PI3K and mTOR Inhibition as a Conserved Therapeutic Vulnerability in Osteosarcoma.	Clin Cancer Res	2015
25571841	Wnt inhibitory factor 1 (WIF1) is a marker of osteoblastic differentiation stage and is not silenced by DNA methylation in osteosarcoma.	Bone	2015
25944566	BET inhibitors induce apoptosis through a MYC independent mechanism and synergise with CDK inhibitors to kill osteosarcoma cells.	Sci Rep	2015
26275108	RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself.	Science	2015
24960165	The Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis.	Journal of Clinical Investigation	2014
26484093	Gene expression profiling to define the cell intrinsic role of the SKI proto-oncogene in hematopoiesis and myeloid neoplasms.	Genomics Data	2014
24415629	The SKI proto-oncogene enhances the in vivo repopulation of hematopoietic stem cells and causes myeloproliferative disease.	Haematologica	2014
23486187	Modeling distinct osteosarcoma subtypes in vivo using Cre:lox and lineage-restricted transgenic shRNA.		2013
20957177	RNAi screen indicates widespread biological function for human natural antisense transcripts.	PLoS ONE	2010
20699480	Disease-specific, neurosphere-derived cells as models for brain disorders.	Dis Model Mech	2010
19377474	The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line.	Nat Genet	2009
19305504	A cross-study transcriptional analysis of Parkinson's disease.	PLoS One	2009
19074369	Genome-wide detection and analysis of hippocampus core promoters using DeepCAGE.	Genome Res	2009
18397893	siRNA specificity searching incorporating mismatch tolerance data.	Bioinformatics	2008
18252196	Focusing on RISC assembly in mammalian cells.	Biochem Biophys Res Commun	2008
18178374	A rescue strategy for multimapping short sequence tags refines surveys of transcriptional activity by CAGE.	Genomics	2008
17322893	Rapid SNP diagnostics using asymmetric isothermal amplification and a new mismatch-suppression technology.	Nat Methods	2007
16507138	Genome-wide review of transcriptional complexity in mouse protein kinases and phosphatases.	Genome Biol	2006
16970923	Differential regulation of osteoadherin (OSAD) by TGF-beta1 and BMP-2.	Biochemical and Biophysical Research Communications	2006
16507160	Alternate transcription of the Toll-like receptor signaling cascade.	Genome Biol	2006
16141073	Antisense transcription in the mammalian transcriptome.	Science	2005
15608162	siRNAdb: a database of siRNA sequences.	Nucleic Acids Res	2005
16141072	The transcriptional landscape of the mammalian genome.	Science	2005
15087316	Sfixem--graphical sequence feature display in Java.	Bioinformatics	2004
15383156	Profiled support vector machines for antisense oligonucleotide efficacy prediction.	BMC Bioinformatics	2004
15158471	Improved and automated prediction of effective siRNA.	Biochem Biophys Res Commun	2004
12490440	Computational antisense oligo prediction with a neural network model.	Bioinformatics	2002