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Author Details

Lewis E Kay
University of Toronto
1985
415
104
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36796143Practical considerations for the measurement of near-surface electrostatics based on solvent paramagnetic relaxation enhancements.J Magn Reson2023
38085782Activation of caspase-9 on the apoptosome as studied by methyl-TROSY NMR.Proc Natl Acad Sci U S A2023
37282495Flexible Client-Dependent Cages in the Assembly Landscape of the Periplasmic Protease-Chaperone DegP.J Am Chem Soc2023
37076542Disrupting the α-synuclein-ESCRT interaction with a peptide inhibitor mitigates neurodegeneration in preclinical models of Parkinson's disease.Nat Commun2023
37011222Correlating histone acetylation with nucleosome core particle dynamics and function.Proc Natl Acad Sci U S A2023
37094170Exploiting conformational dynamics to modulate the function of designed proteins.Proc Natl Acad Sci U S A2023
36508761Less is more: A simple methyl-TROSY based pulse scheme offers improved sensitivity in applications to high molecular weight complexes.J Magn Reson2023
36496075Surface electrostatics dictate RNA-binding protein CAPRIN1 condensate concentration and hydrodynamic properties.J Biol Chem2023
36192571Optimizing frequency sampling in CEST experiments.J Biomol NMR2022
35452308Structural basis of protein substrate processing by human mitochondrial high-temperature requirement A2 protease.Proc Natl Acad Sci U S A2022
35622310Towards autonomous analysis of chemical exchange saturation transfer experiments using deep neural networks.J Biomol NMR2022
36040869Mapping the per-residue surface electrostatic potential of CAPRIN1 along its phase-separation trajectory.Proc Natl Acad Sci U S A2022
36018482Measurement of <sup>1</sup>H<sup>α</sup> transverse relaxation rates in proteins: application to solvent PREs.J Biomol NMR2022
32814359Allovalency observed by transferred NOE: interactions of sulfated tyrosine residues in the N-terminal segment of CCR5 with the CCL5 chemokine.FEBS J2021
33545034NMR spectroscopy captures the essential role of dynamics in regulating biomolecular function.Cell2021
33711750A life writ large: Chris Dobson 1949-2019.J Magn Reson2021
33707571Global multi-method analysis of interaction parameters for reversibly self-associating macromolecules at high concentrations.Sci Rep2021
33692127Oligomeric assembly regulating mitochondrial HtrA2 function as examined by methyl-TROSY NMR.Proc Natl Acad Sci U S A2021
34893543Probing allosteric interactions in homo-oligomeric molecular machines using solution NMR spectroscopy.Proc Natl Acad Sci U S A2021
34764225The A39G FF domain folds on a volcano-shaped free energy surface via separate pathways.Proc Natl Acad Sci U S A2021
34799442Opening of a cryptic pocket in β-lactamase increases penicillinase activity.Proc Natl Acad Sci U S A2021
34446566Dissecting the role of interprotomer cooperativity in the activation of oligomeric high-temperature requirement A2 protein.Proc Natl Acad Sci U S A2021
34074792Interaction hot spots for phase separation revealed by NMR studies of a CAPRIN1 condensed phase.Proc Natl Acad Sci U S A2021
34362850Competing stress-dependent oligomerization pathways regulate self-assembly of the periplasmic protease-chaperone DegP.Proc Natl Acad Sci U S A2021
32286073Confronting the Invisible: Assignment of Protein <sup>1</sup>H<sup>N</sup> Chemical Shifts in Cases of Extreme Broadening.J Phys Chem Lett2020
31668683A tribute to James H. Prestegard - 75⿯years young!J Magn Reson2020
31898464NMR Experiments for Studies of Dilute and Condensed Protein Phases: Application to the Phase-Separating Protein CAPRIN1.J Am Chem Soc2020
31835059Unveiling invisible protein states with NMR spectroscopy.Curr Opin Struct Biol2020
31916936A processive rotary mechanism couples substrate unfolding and proteolysis in the ClpXP degradation machinery.Elife2020
32094174Exploring long-range cooperativity in the 20S proteasome core particle from <i>Thermoplasma acidophilum</i> using methyl-TROSY-based NMR.Proc Natl Acad Sci U S A2020
33028677An intrinsically disordered motif regulates the interaction between the p47 adaptor and the p97 AAA+ ATPase.Proc Natl Acad Sci U S A2020
33232135A pH-Dependent Conformational Switch Controls <i>N. meningitidis</i> ClpP Protease Function.J Am Chem Soc2020
32857889Probing Cooperativity of N-Terminal Domain Orientations in the p97 Molecular Machine: Synergy Between NMR Spectroscopy and Cryo-EM.Angew Chem Int Ed Engl2020
32631553Structural basis for the stabilization of amyloidogenic immunoglobulin light chains by hydantoins.Bioorg Med Chem Lett2020
32997264The methyl <sup>13</sup>C-edited/<sup>13</sup>C-filtered transferred NOE for studying protein interactions with short linear motifs.J Biomol NMR2020
32818875Analyzing multi-step ligand binding reactions for oligomeric proteins by NMR: Theoretical and computational considerations.J Magn Reson2020
32123115An allosteric switch regulates <i>Mycobacterium tuberculosis</i> ClpP1P2 protease function as established by cryo-EM and methyl-TROSY NMR.Proc Natl Acad Sci U S A2020
32457157A methyl-TROSY approach for NMR studies of high-molecular-weight DNA with application to the nucleosome core particle.Proc Natl Acad Sci U S A2020
30584095Cooperative subunit dynamics modulate p97 function.Proc Natl Acad Sci U S A2019
31646421Revisiting <sup>1</sup>H<sup>N</sup> CPMG relaxation dispersion experiments: a simple modification can eliminate large artifacts.J Biomol NMR2019
31754640ClpP protease activation results from the reorganization of the electrostatic interaction networks at the entrance pores.Commun Biol2019
31439799Phospho-dependent phase separation of FMRP and CAPRIN1 recapitulates regulation of translation and deadenylation.Science2019
31324584The evolution of solution state NMR pulse sequences through the 'eyes' of triple-resonance spectroscopy.J Magn Reson2019
31422487Editorial.J Biomol NMR2019
31364359The Role of Protein Thermodynamics and Primary Structure in Fibrillogenesis of Variable Domains from Immunoglobulin Light Chains.J Am Chem Soc2019
30798393Artifacts can emerge in spectra recorded with even the simplest of pulse schemes: an HMQC case study.J Biomol NMR2019
30971495Stabilization of amyloidogenic immunoglobulin light chains by small molecules.Proc Natl Acad Sci U S A2019
30847985A Methyl-TROSY-Based <sup>1</sup> H Relaxation Dispersion Experiment for Studies of Conformational Exchange in High Molecular Weight Proteins.Angew Chem Int Ed Engl2019
30901260An NMR View of Protein Dynamics in Health and Disease.Annu Rev Biophys2019
30598439Role of domain interactions in the aggregation of full-length immunoglobulin light chains.Proc Natl Acad Sci U S A2019
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Collaborators

Julie D Forman-Kay
Hospital for Sick Children
Co-authored papers 51
Dmitry M Korzhnev
University of Connecticut Health Center
Co-authored papers 29
Ad Bax
National Institutes of Health
Co-authored papers 15
Tony Pawson
Co-authored papers 14
Kevin H Gardner
CUNY Advanced Science Research Center
Co-authored papers 9
Alan R Davidson
University of Toronto, University Avenue
Co-authored papers 7
Michele Vendruscolo
University of Cambridge
Co-authored papers 7
Michael K Rosen
UT Southwestern Medical Center
Co-authored papers 6
Cheryl H Arrowsmith
University of Toronto
Co-authored papers 6
Aaron D Schimmer
Princess Margaret Cancer Centre
Co-authored papers 5
Irina Bezsonova
University of Connecticut Health Center
Co-authored papers 5
Angela M Gronenborn
University of Pittsburgh
Co-authored papers 5
Walid A Houry
University of Toronto
Co-authored papers 5
David Baker
University of Washington
Co-authored papers 4
Alan R Fersht
Medical Research Council Laboratory of Molecular Biology
Co-authored papers 4
Jack F Greenblatt
College Street, University of Toronto
Co-authored papers 4
Joyce Li
University of Toronto, College Street
Co-authored papers 3
Suzanne Trudel
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 3
Bernd Reif
Technische Universitat Munchen (TUM)
Co-authored papers 2
Tanja Kortemme
University of California san francisco
Co-authored papers 2
Zanlin Yu
University of California at San Francisco
Co-authored papers 2
Zhihua Li
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 2
Daniela Rotin
The Hospital for Sick Children
Co-authored papers 2
Rieko Ishima
University of Pittsburgh School of Medicine
Co-authored papers 2
David Neuhaus
Medical Research Council - Laboratory of Molecular Biology
Co-authored papers 2
Paul C Driscoll
The Francis Crick Institute
Co-authored papers 2
David R Rose
University of Waterloo, University Avenue West
Co-authored papers 2
Ian A Wilson
The Scripps Research Institute, USA The Skaggs Institute for Chemical Biology
Co-authored papers 2
Oliver F Lange
Center for Integrated Protein Science, Technische Universitat Munchen
Co-authored papers 2
Carol V Robinson
University of Oxford
Co-authored papers 2
Release 1.2