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Author Details

Daniel Bottomly
Knight Cancer Institute, Oregon Health & Science University
2009
46
19
PMIDPaper TitleJournal TitlePublished Year
36264026Secondary fusion proteins as a mechanism of BCR::ABL1 kinase-independent resistance in chronic myeloid leukaemia.Br J Haematol2023
37698624Clinical Correlates of Venetoclax-Based Combination Sensitivities to Augment Acute Myeloid Leukemia Therapy.Blood Cancer Discov2023
36976323Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia.Mol Cancer Res2023
37361575Immune cell proportions correlate with clinicogenomic features and <i>ex vivo</i> drug responses in acute myeloid leukemia.Front Oncol2023
36441905Comparison and validation of the 2022 European LeukemiaNet guidelines in acute myeloid leukemia.Blood Adv2023
33375770Genome-wide CRISPR screen identifies regulators of MAPK and MTOR pathways mediating sorafenib resistance in acute myeloid leukemia.Haematologica2022
35343367Functional proteomics of patient derived head and neck squamous cell carcinoma cells reveal novel applications of trametinib.Cancer Biol Ther2022
35499387Luxeptinib (CG-806) Targets FLT3 and Clusters of Kinases Operative in Acute Myeloid Leukemia.Mol Cancer Ther2022
35868306Integrative analysis of drug response and clinical outcome in acute myeloid leukemia.Cancer Cell2022
35296646Dual BTK/SYK inhibition with CG-806 (luxeptinib) disrupts B-cell receptor and Bcl-2 signaling networks in mantle cell lymphoma.Cell Death Dis2022
35078224Associating drug sensitivity with differentiation status identifies effective combinations for acute myeloid leukemia.Blood Adv2022
34482403Identification and prioritization of myeloid malignancy germline variants in a large cohort of adult patients with AML.Blood2022
34171263The AML microenvironment catalyzes a stepwise evolution to gilteritinib resistance.Cancer Cell2021
33780043A noncanonical FLT3 gatekeeper mutation disrupts gilteritinib binding and confers resistance.Am J Hematol2021
34568834Monocytic differentiation and AHR signaling as Primary Nodes of BET Inhibitor Response in Acute Myeloid Leukemia.Blood Cancer Discov2021
34301758Lentiviral-Driven Discovery of Cancer Drug Resistance Mutations.Cancer Res2021
32366937ERBB2/HER2 mutations are transforming and therapeutically targetable in leukemia.Leukemia2020
33123685Integrated analysis of patient samples identifies biomarkers for venetoclax efficacy and combination strategies in acute myeloid leukemia.Nat Cancer2020
32315394Discovery and characterization of targetable NTRK point mutations in hematologic neoplasms.Blood2020
30651561Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms.Nat Commun2019
31779979What do functional genomics tell us about pathogenesis of AML?Best Pract Res Clin Haematol2019
31366621Genomic landscape of neutrophilic leukemias of ambiguous diagnosis.Blood2019
30333627Functional genomic landscape of acute myeloid leukaemia.Nature2018
30018082Synthetic lethality of TNK2 inhibition in PTPN11-mutant leukemia.Sci Signal2018
28630439Recurrent cyclin D2 mutations in myeloid neoplasms.Leukemia2017
28439110Characterization of the leukemogenic potential of distal cytoplasmic CSF3R truncation and missense mutations.Leukemia2017
28652245Unpaired Extracellular Cysteine Mutations of CSF3R Mediate Gain or Loss of Function.Cancer Res2017
26708334HitWalker2: visual analytics for precision medicine and beyond.Bioinformatics2016
26677978Identification and Characterization of Tyrosine Kinase Nonreceptor 2 Mutations in Leukemia through Integration of Kinase Inhibitor Screening and Genomic Analysis.Cancer Res2016
25924931plethy: management of whole body plethysmography data in R.BMC Bioinformatics2015
26032424Therapeutically Targetable ALK Mutations in Leukemia.Cancer Res2015
24374554The genetics of gene expression in complex mouse crosses as a tool to study the molecular underpinnings of behavior traits.Mamm Genome2014
25172470Analysis considerations for utilizing RNA-Seq to characterize the brain transcriptome.Int Rev Neurobiol2014
23303510HitWalker: variant prioritization for personalized functional cancer genomics.Bioinformatics2013
24286512Comparison of methods to identify aberrant expression patterns in individual patients: augmenting our toolkit for precision medicine.Genome Med2013
23656643Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML.N Engl J Med2013
23704919Androgen receptor promotes ligand-independent prostate cancer progression through c-Myc upregulation.PLoS One2013
23468633Modeling host genetic regulation of influenza pathogenesis in the collaborative cross.PLoS Pathog2013
23194347Genes, behavior and next-generation RNA sequencing.Genes Brain Behav2013
22384400Expression quantitative trait Loci for extreme host response to influenza a in pre-collaborative cross mice.G3 (Bethesda)2012
22969789Detection of expression quantitative trait Loci in complex mouse crosses: impact and alleviation of data quality and complex population substructure.Front Genet2012
22556371Utilizing RNA-Seq data for de novo coexpression network inference.Bioinformatics2012
21455293Evaluating gene expression in C57BL/6J and DBA/2J mouse striatum using RNA-Seq and microarrays.PLoS One2011
21946329A DNA methylation microarray-based study identifies ERG as a gene commonly methylated in prostate cancer.Epigenetics2011
20460455Identification of {beta}-catenin binding regions in colon cancer cells using ChIP-Seq.Nucleic Acids Res2010
19686600High throughput sequencing in mice: a platform comparison identifies a preponderance of cryptic SNPs.BMC Genomics2009
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Collaborators

Shannon K McWeeney
Oregon Health & Science University, University of California Berkeley
Co-authored papers 45
Jeffrey W Tyner
Oregon Health & Science University School of Medicine
Co-authored papers 29
Beth Wilmot
Knight Cancer Institute, Oregon Health & Science University
Co-authored papers 25
Brian J Druker
Oregon Health & Science University
Co-authored papers 22
Christopher A Eide
Knight Cancer Institute, Oregon Health & Science University
Co-authored papers 15
Cristina E Tognon
Knight Cancer Institute, Oregon Health & Science University
Co-authored papers 11
Nicola Long
Oregon Health and Science University
Co-authored papers 9
Robert P Searles
Oregon Health & Science University
Co-authored papers 8
Julia E Maxson
Knight Cancer Institute, Oregon Health & Science University
Co-authored papers 8
Bill H Chang
Oregon Health and Science University
Co-authored papers 8
Haijiao Zhang
Oregon Health & Science University, Knight Cancer Institute
Co-authored papers 7
Stephen E Kurtz
Knight Cancer Institute, Oregon Health and Science University
Co-authored papers 7
Marc M Loriaux
Knight Cancer Institute, Oregon Health & Science University
Co-authored papers 7
Elie Traer
Oregon Health & Science University
Co-authored papers 7
Andy Kaempf
Knight Cancer Institute, Oregon Health & Science University
Co-authored papers 7
Robert Hitzemann
Portland Alcohol Research Center, Oregon Health and Science University
Co-authored papers 6
Samuel B Luty
Knight Cancer Institute, Oregon Health & Science University
Co-authored papers 6
Robert H Collins
University of Texas Southwestern Medical Center
Co-authored papers 6
Tamilla Nechiporuk
Knight Cancer Institute, Oregon Health and Science University
Co-authored papers 6
Anupriya Agarwal
Knight Cancer Institute, Oregon Health & Science University
Co-authored papers 6
Daniel A Pollyea
University of Colorado Division of Hematology
Co-authored papers 5
Michael W Deininger
University of Utah Huntsman Cancer Institute
Co-authored papers 5
Melissa L Abel
National Cancer Institute, National Institutes of Health
Co-authored papers 4
Sunil K Joshi
Knight Cancer Institute, Oregon Health & Science University
Co-authored papers 4
Chenwei Lin
Clinical Research Division, Fred Hutchinson Cancer Center
Co-authored papers 4
Rachel Henson
Knight Cancer Institute, Oregon Health & Science University
Co-authored papers 4
Priscila Darakjian
Oregon National Primate Research Center
Co-authored papers 4
Sunita Kawane
Clinical & Translational Research Institute, Oregon Health and Science University
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Ronan Swords
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Ovidiu D Iancu
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Release 1.2